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Molecular targets of exercise mimetics and their natural activators

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Physical exercise can be effective in preventing or amelioratingvarious diseases, including diabetes, cardiovascular diseases,neurodegenerative diseases, and cancer. However, not everyonemay be able to participate in exercise due to illnesses, age-relatedfrailty, or difficulty in long-term behavior change. Analternative option is to utilize pharmacological interventions thatmimic the positive effects of exercise training. Recent studieshave identified signaling pathways associated with the benefitsof physical activity and discovered exercise mimetics that canpartially simulate the systemic impact of exercise. This reviewdescribes the molecular targets for exercise mimetics and theireffect on skeletal muscle and other tissues. We will also discussthe potential advantages of using natural products as a multitargetingagent for mimicking the health-promoting effects ofexercise.

Abstract

Physical exercise can be effective in preventing or amelioratingvarious diseases, including diabetes, cardiovascular diseases,neurodegenerative diseases, and cancer. However, not everyonemay be able to participate in exercise due to illnesses, age-relatedfrailty, or difficulty in long-term behavior change. Analternative option is to utilize pharmacological interventions thatmimic the positive effects of exercise training. Recent studieshave identified signaling pathways associated with the benefitsof physical activity and discovered exercise mimetics that canpartially simulate the systemic impact of exercise. This reviewdescribes the molecular targets for exercise mimetics and theireffect on skeletal muscle and other tissues. We will also discussthe potential advantages of using natural products as a multitargetingagent for mimicking the health-promoting effects ofexercise.

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