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Therapeutic implications of microRNAs in pulmonary arterial hypertension

김종민|최지혜|장우철|이아람|Danielle McLean|강혜수
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2014.06|BMB Reports|제47권 제6호|pp. 311-317

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참고문헌

키워드

BiomarkerSignaling pathwayPulmonary arterial hypertensionmicroRNAPulmonary vascular cell
주제분류화학

초록

microRNAs (miRNAs) are a class of small, non-coding RNAsthat play critical posttranscriptional regulatory roles typicallythrough targeting of the 3'-untranslated region of messengerRNA (mRNA). Mature miRNAs are known to be involved inglobal cellular processes, such as differentiation, proliferation,apoptosis, and organogenesis, due to their capacity to targetmultiple mRNAs. Thus, imbalances in the expression and/oractivity of miRNAs are involved in the pathogenesis ofnumerous diseases, including pulmonary arterial hypertension(PAH). PAH is a progressive disease characterized by vascularremodeling due to excessive proliferation of pulmonary arteryendothelial cells (PAECs) and pulmonary artery smooth musclecells (PASMCs). Recently, studies have evaluated the roles ofmiRNAs involved in the pathogenesis of PAH in thesepulmonary vascular cells. This review provides an overview ofrecent discoveries on the role of miRNAs in the pathogenesis ofPAH and discusses the potential for miRNAs as therapeutictargets and biomarkers of PAH.

Abstract

microRNAs (miRNAs) are a class of small, non-coding RNAsthat play critical posttranscriptional regulatory roles typicallythrough targeting of the 3'-untranslated region of messengerRNA (mRNA). Mature miRNAs are known to be involved inglobal cellular processes, such as differentiation, proliferation,apoptosis, and organogenesis, due to their capacity to targetmultiple mRNAs. Thus, imbalances in the expression and/oractivity of miRNAs are involved in the pathogenesis ofnumerous diseases, including pulmonary arterial hypertension(PAH). PAH is a progressive disease characterized by vascularremodeling due to excessive proliferation of pulmonary arteryendothelial cells (PAECs) and pulmonary artery smooth musclecells (PASMCs). Recently, studies have evaluated the roles ofmiRNAs involved in the pathogenesis of PAH in thesepulmonary vascular cells. This review provides an overview ofrecent discoveries on the role of miRNAs in the pathogenesis ofPAH and discusses the potential for miRNAs as therapeutictargets and biomarkers of PAH.

참고문헌 (47)

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관련 논문AI추천

MicroRNA in the Diseased Pulmonary Vasculature: Implications for the Basic Scientist and Clinician민필기, Richard C. Jin, MD, Stephen Y. Chan, MD대한고혈압학회 · Clinical Hypertension2013 · 제19권 제1호MicroRNAs as critical regulators of the endothelial to mesenchymal transition in vascular biology김종민생화학분자생물학회 · BMB Reports2018 · 제51권 제2호miR-15b induced by platelet-derived growth factor signaling is required for vascular smooth muscle cell proliferation강하라, 김성환생화학분자생물학회 · BMB Reports2013 · 제46권 제11호MicroRNAs in Human Diseases: From Cancer to Cardiovascular Disease하대유대한면역학회 · Immune Network2011 · 제11권 제3호Crosstalk between BMP signaling and KCNK3 in phenotypic switching of pulmonary vascular smooth muscle cells서원희, Hayoung Jeong, Koung Li Kim, Min-Ju Kim, Yanghee Choi, Yeongju Yeo생화학분자생물학회 · BMB Reports2022 · 제55권 제11호Hypoxia-induced miR-1260b regulates vascular smooth muscle cell proliferation by targeting GDF11강하라, Minhyeong Seong생화학분자생물학회 · BMB Reports2020 · 제53권 제4호

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