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MicroRNAs as critical regulators of the endothelial to mesenchymal transition in vascular biology

김종민
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2018.02|BMB Reports|제51권 제2호|pp. 65-72

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참고문헌

키워드

Endothelial cellVascular diseaseMicroRNAEndothelial dysfunctionEndothelial to mesenchymal transition
주제분류화학

초록

The endothelial to mesenchymal transition (EndMT) is a newly recognized, fundamental biological process involved in development and tissue regeneration, as well as pathological processes such as the complications of diabetes, fibrosis and pulmonary arterial hypertension. The EndMT process is tightly controlled by diverse signaling networks, similar to the epithelial to mesenchymal transition. Accumulating evidence suggests that microRNAs (miRNAs) are key regulators of this network, with the capacity to target multiple messenger RNAs involved in the EndMT process as well as in the regulation of disease progression. Thus, it is highly important to understand the molecular basis of miRNA control of EndMT. This review highlights the current fund of knowledge regarding the known links between miRNAs and the EndMT process, with a focus on the mechanism that regulates associated signaling pathways and discusses the potential for the EndMT as a therapeutic target to treat many diseases.

Abstract

The endothelial to mesenchymal transition (EndMT) is a newly recognized, fundamental biological process involved in development and tissue regeneration, as well as pathological processes such as the complications of diabetes, fibrosis and pulmonary arterial hypertension. The EndMT process is tightly controlled by diverse signaling networks, similar to the epithelial to mesenchymal transition. Accumulating evidence suggests that microRNAs (miRNAs) are key regulators of this network, with the capacity to target multiple messenger RNAs involved in the EndMT process as well as in the regulation of disease progression. Thus, it is highly important to understand the molecular basis of miRNA control of EndMT. This review highlights the current fund of knowledge regarding the known links between miRNAs and the EndMT process, with a focus on the mechanism that regulates associated signaling pathways and discusses the potential for the EndMT as a therapeutic target to treat many diseases.

참고문헌 (55)

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관련 논문AI추천

MicroRNA in the Diseased Pulmonary Vasculature: Implications for the Basic Scientist and Clinician민필기, Richard C. Jin, MD, Stephen Y. Chan, MD대한고혈압학회 · Clinical Hypertension2013 · 제19권 제1호Therapeutic implications of microRNAs in pulmonary arterial hypertension강혜수, 김종민, 이아람, 장우철, 최지혜, Danielle McLean생화학분자생물학회 · BMB Reports2014 · 제47권 제6호Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transitionDongrui Chen, Lian Xu, Maoqing Ye, Mengxia Fu, Michael C. Ostrowski, Paul Grossfeld, Pingjin Gao, Weiqing Han생화학분자생물학회 · BMB Reports2019 · 제52권 제10호Flow goes forward and cells step backward: endothelial migrationLee Heon-Woo, Shin Jae Hun, Simons Michael생화학분자생물학회 · Experimental and Molecular Medicine2022 · 제54권 miR-15b induced by platelet-derived growth factor signaling is required for vascular smooth muscle cell proliferation강하라, 김성환생화학분자생물학회 · BMB Reports2013 · 제46권 제11호Endothelial miR-26a regulates VEGF-Nogo-B receptor-mediated angiogenesis강혜수, 김종민, 이명석, 이아람, 장우철, 조하늘, 최지혜생화학분자생물학회 · BMB Reports2017 · 제50권 제7호

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