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Mycobacterium abscessus MAB2560 induces maturation of dendritic cells via Toll-like receptor 4 and drives Th1 immune response

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In this study, we showed that Mycobacterium abscessusMAB2560 induces the maturation of dendritic cells (DCs),which are representative antigen-presenting cells (APCs). M. abscessus MAB2560 stimulate the production of pro-inflammatorycytokines [interleukin (IL)-6, tumor necrosis factor (TNF)-α,IL-1β, and IL-12p70] and reduce the endocytic capacity andmaturation of DCs. Using TLR4-/- DCs, we found that MAB2560mediated DC maturation via Toll-like receptor 4 (TLR4). MAB2560 also activated the MAPK signaling pathway, whichwas essential for DC maturation. Furthermore, MAB2560-treated DCs induced the transformation of naïve T cells topolarized CD4+ and CD8+ T cells, which would be crucial forTh1 polarization of the immune response. Taken together, ourresults indicate that MAB2560 could potentially regulate thehost immune response to M. abscessus and may have criticalimplications for the manipulation of DC functions fordeveloping DC-based immunotherapy.

Abstract

In this study, we showed that Mycobacterium abscessusMAB2560 induces the maturation of dendritic cells (DCs),which are representative antigen-presenting cells (APCs). M. abscessus MAB2560 stimulate the production of pro-inflammatorycytokines [interleukin (IL)-6, tumor necrosis factor (TNF)-α,IL-1β, and IL-12p70] and reduce the endocytic capacity andmaturation of DCs. Using TLR4-/- DCs, we found that MAB2560mediated DC maturation via Toll-like receptor 4 (TLR4). MAB2560 also activated the MAPK signaling pathway, whichwas essential for DC maturation. Furthermore, MAB2560-treated DCs induced the transformation of naïve T cells topolarized CD4+ and CD8+ T cells, which would be crucial forTh1 polarization of the immune response. Taken together, ourresults indicate that MAB2560 could potentially regulate thehost immune response to M. abscessus and may have criticalimplications for the manipulation of DC functions fordeveloping DC-based immunotherapy.

참고문헌 (25)

  1. Banchereau, J., "Dendritic cells and the control of immunity", Nature, 392, pp.245~252 (1998)
  2. Janeway, C. A., Jr., "Introduction: the role of innate immunity in the adaptive immune response", Semin. Immunol, 10, pp.349~350 (1998)
  3. Falkinham, J. O., 3rd, "Nontuberculous mycobacteria in the environment", Clin. Chest. Med, 23, pp.529~551 (2002)
  4. Griffith, D. E., "An official ATS", IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases, 2007, pp.175, 367~416
  5. Horsburgh, C. R., Jr., "The epidemiology of disseminated nontuberculous mycobacterial infection in the acquired immunodeficiency syndrome (AIDS)", Am. Rev. Respir. Dis, 139, pp.4~7 (1989)
  6. Brown-Elliott, B. A., "Clinical and taxonomic status of pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria", Clin. Microbiol. Rev, 15, pp.716~746 (2002)
  7. Shin, D. M., "Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1", Cell Microbiol, 10, pp.1608~1621 (2008)
  8. Agrawal, S., "Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos", J. Immunol, 171, pp.4984~4989 (2003)
  9. Noss, E. H., "Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis", J.Immunol, 167, pp.910~918 (2001)
  10. Pecora, N. D., "Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function", J. Immunol, 177, pp.422~429 (2006)
  11. Gehring, A. J., "Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing", J. Immunol, 173, pp.2660~2668 (2004)
  12. Quesniaux, V. J., "Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans", J. Immunol, 172, pp.4425~4434 (2004)
  13. Jones, B. W., "Different Toll-like receptor agonists induce distinct macrophage responses", J. Leukoc. Biol, 69, pp.1036~1044 (2001)
  14. Gilleron, M., "Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guerin and mycobacterium tuberculosis H37Rv and its implication in Toll-like receptor response", J. Biol. Chem, 278, pp.29880~29889 (2003)
  15. Bansal, K., "PE_PGRS antigens of Mycobacterium tuberculosis induce maturation and activation of human dendritic cells", J. Immunol, 184, pp.3495~3504 (2010)
  16. Jung, I. D., "Enhanced efficacy of therapeutic cancer vaccines produced by co-treatment with Mycobacterium tuberculosis heparin-binding hemagglutinin, a novel TLR4 agonist", Cancer Res, 71, pp.2858~2870 (2011)
  17. Byun, E. H., "Mycobacterium paratuberculosis CobT activates dendritic cells via engagement of Toll-like receptor 4 resulting in Th1 cell expansion", J. Biol. Chem, 287, pp.38609~38624 (2012)
  18. Hayashi, F., "The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5", Nature, 410, pp.1099~1103 (2001)
  19. Sampaio, E. P., "Mycobacterium abscessus and M. avium trigger Toll-like receptor 2 and distinct cytokine response in human cells", Am. J. Respir. Cell. Mol. Biol, 39, pp.431~439 (2008)
  20. 심윤수, "Impaired Expression of MAPK Is Associated with the Downregulation of TNF-α, IL-6, and IL-10 in Mycobacterium abscessus Lung Disease", Tuberculosis and Respiratory Diseases, 72(3), pp.275~283 (2012), 대한결핵및호흡기학회
  21. Ordway, D., "Animal model of Mycobacterium abscessus lung infection", J. Leukoc. Biol, 83, pp.1502~1511 (2008)
  22. Vilcek, J., "Defective gamma-interferon production in peripheral blood leukocytes of patients with acute tuberculosis", J. Clin. Immunol, 6, pp.146~151 (1986)
  23. Lee, J. S., "Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein activates dendritic cells and induces a Th1 polarization", Infect. Immun, 77, pp.2979~2988 (2009)
  24. Lee, S. J., "The Mycobacterium avium subsp. Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4", BMB Rep, 47, pp.115~120 (2014)
  25. Noh, K. T., "Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1", 2 (ERK1, J. Biol. Chem, pp.2012, 287[DOI]

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