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MicroRNA: trends in clinical trials of cancer diagnosis and therapy strategies

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초록

As a type of short noncoding RNAs, microRNA (miRNA) undoubtedly plays a crucial role in cancer development. Since the discovery of the identity and clinical functions of miRNAs, over the past few decades, the roles of miRNAs in cancer have been actively investigated. Numerous pieces of evidence indicate that miRNAs are pivotal factors in most types of cancer. Recent cancer research focused on miRNAs has identified and characterized a large cohort of miRNAs commonly dysregulated in cancer or exclusively dysregulated in specific types of cancer. These studies have suggested the potential of miRNAs as biomarkers in the diagnosis and prognostication of cancer. Moreover, many of these miRNAs have oncogenic or tumor-suppressive functions. MiRNAs have been the focus of research given their potential clinical applications as therapeutic targets. Currently, various oncology clinical trials using miRNAs in screening, diagnosis, and drug testing are underway. Although clinical trials studying miRNAs in various diseases have been reviewed before, there have been fewer clinical trials related to miRNAs in cancer. Furthermore, updated results of recent preclinical studies and clinical trials of miRNA biomarkers and drugs in cancer are needed. Therefore, this review aims to provide up-to-date information on miRNAs as biomarkers and cancer drugs in clinical trials.

Abstract

As a type of short noncoding RNAs, microRNA (miRNA) undoubtedly plays a crucial role in cancer development. Since the discovery of the identity and clinical functions of miRNAs, over the past few decades, the roles of miRNAs in cancer have been actively investigated. Numerous pieces of evidence indicate that miRNAs are pivotal factors in most types of cancer. Recent cancer research focused on miRNAs has identified and characterized a large cohort of miRNAs commonly dysregulated in cancer or exclusively dysregulated in specific types of cancer. These studies have suggested the potential of miRNAs as biomarkers in the diagnosis and prognostication of cancer. Moreover, many of these miRNAs have oncogenic or tumor-suppressive functions. MiRNAs have been the focus of research given their potential clinical applications as therapeutic targets. Currently, various oncology clinical trials using miRNAs in screening, diagnosis, and drug testing are underway. Although clinical trials studying miRNAs in various diseases have been reviewed before, there have been fewer clinical trials related to miRNAs in cancer. Furthermore, updated results of recent preclinical studies and clinical trials of miRNA biomarkers and drugs in cancer are needed. Therefore, this review aims to provide up-to-date information on miRNAs as biomarkers and cancer drugs in clinical trials.

참고문헌 (110)

  1. Ambros, V., "The functions of animal microRNAs", Nature, 431, pp.350~355 (2004)
  2. Wightman, B., "Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans", Cell, 75, pp.855~862 (1993)
  3. Lee, R. C., "The C. elegans heterochronic gene lin-4encodes small RNAs with antisense complementarity to lin-14", Cell, 75, pp.843~854 (1993)
  4. Kim, T., "MicroRNA and ER stress in cancer", Semin. Cancer Biol, 75, pp.3~14 (2021)
  5. Miyoshi, K., "Many ways to generate microRNA-like small RNAs : non-canonical pathways for microRNA production", Mol. Genet. Genom, 284, pp.95~103 (2010)
  6. Jame-Chenarboo, F., "High-Throughput Analysis Reveals miRNA Upregulating α-2, 6-Sialic Acid through Direct miRNA–mRNA Interactions", ACS Cent. Sci, 8, pp.1527~1536 (2022)
  7. Laitinen, P., "Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia", PLOS ONE, 17, pp.e0265948~ (2022)
  8. Calin, G. A., "Nonlinear partial differential equations and applications : Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia", Proc. Natl Acad. Sci, 99, pp.15524~15529 (2002)
  9. He, L., "A microRNA component of the p53 tumour suppressor network", Nature, 447, pp.1130~1134 (2007)
  10. Raver-Shapira, N., "Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis", Mol. Cell, 26, pp.731~743 (2007)
  11. Kim, T., "p53 regulates epithelial–mesenchymal transition through micro-RNAs targeting ZEB1 and ZEB2", J. Exp. Med, 208, pp.875~883 (2011)
  12. O’Donnell, K. A., "c-Mycregulated microRNAs modulate E2F1 expression", Nature, 435, pp.839~843 (2005)
  13. Calin, G. A., "MicroRNA signatures in human cancers", Nat. Rev. Cancer, 6, pp.857~866 (2006)
  14. Li, Y., "MicroRNAs in Common Human Diseases", Genom. Proteom. Bioinforma, 10, pp.246~253 (2012)
  15. Chakraborty, C., "Therapeutic advances of miRNAs : A preclinical and clinical update", J. Adv. Res, 28, pp.127~138 (2021)
  16. Gallant-Behm, C. L., "A synthetic microRNA-92a inhibitor(MRG-110)accelerates angiogenesis and wound healing in diabetic and nondiabetic wounds", Wound Repair Regener, 26, pp.311~323 (2018)
  17. Doebele, C., "Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells", Blood, 115, pp.4944~4950 (2010)
  18. Abplanalp, W. T., "Efficiency and Target Derepression of Anti-miR-92a : Results of a First in Human Study", Nucleic Acid Ther, 30, pp.335~345 (2020)
  19. Lee, T. -H., "MicroRNA-122 associates with serum apolipoprotein B but not liver fibrosis markers in CHC genotype 1 infection", J. Med. Virol, 87, pp.1722~1726 (2015)
  20. Ottosen, S., "In Vitro Antiviral Activity and Preclinical and Clinical Resistance Profile of Miravirsen, a Novel Anti-Hepatitis C Virus Therapeutic Targeting the Human Factor miR-122", Antimicrobial Agents Chemother, 59, pp.599~608 (2014)
  21. Patel, V., "miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease", Proc. Natl Acad. Sci, 110, pp.10765~10770 (2013)
  22. Lee, E. C., "Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease", Nat. Commun, 10, pp.4148~ (2019)
  23. Bais, T., "Drugs in Clinical Development to Treat Autosomal Dominant Polycystic Kidney Disease", Drugs, 82, pp.1095~1115 (2022)
  24. Hanna, J., "The Potential for microRNA Therapeutics and Clinical Research", Front. Genet, 10, pp.478~ (2019)
  25. Chioccioli, M., "A lung targeted miR-29 mimic as a therapy for pulmonary fibrosis", eBioMedicine, 85, pp.104304~ (2022)
  26. Sung, J. J. Y., "Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after Helicobacter pylori eradication", Gut, 69, pp.1572~1580 (2020)
  27. Ji, J., "Using Probiotics as Supplementation for Helicobacter pylori Antibiotic Therapy", Int. J. Mol. Sci, 21, pp.1136~ (2020)
  28. Russo, F., "Probiotics against neoplastic transformation of gastric mucosa : Effects on cell proliferation and polyamine metabolism", World J. Gastroenterol, 20, pp.13258~ (2014)
  29. Yang, J., "Role of the Gastric Microbiome in Gastric Cancer : From Carcinogenesis to Treatment", Front. Microbiol, 12, pp.641322~ (2021)
  30. Bakhti, S. Z., "Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis", BMC Microbiol, 21, pp.258~ (2021)
  31. Penumetcha, S. S., "The Efficacy of Probiotics in the Management of Helicobacter Pylori : A Systematic Review", Cureus, 13, pp.e20483~ (2021)
  32. Yue, H., "MIR-519d suppresses the gastric cancer epithelial-mesenchymal transition via Twist1 and inhibits Wnt", β-catenin signaling pathway, 2017, pp.9, 3654~3664
  33. Yanaka, Y., "miR-544a induces epithelial–mesenchymal transition through the activation of WNT signaling pathway in gastric cancer", Carcinogenesis, 36, pp.1363~1371 (2015)
  34. Wu, K., "miR-483-5p promotes growth, invasion and self-renewal of gastric cancer stem cells by Wnt", β-catenin signaling, 2016, pp.14, 3421~3428
  35. Fan, D., "Upregulation of miR-501-5p activates the wnt", β-catenin signaling pathway and enhances stem cell-like phenotype in gastric cancer, 2016, pp.35, 177~
  36. Cheng, C., "Knockdown of long non-coding RNA HOTAIR inhibits cisplatin resistance of gastric cancer cells through inhibiting the PI3K", Akt and Wnt, Int. J. Biol. Macromol, pp.2018, 107[DOI]
  37. Sun, G. -L., "miR-324-3p promotes gastric cancer development by activating Smad4-mediated Wnt", beta-catenin signaling pathway, 2017, pp.53, 725~739
  38. Huang, J., "miR-302b inhibits tumorigenesis by targeting EphA2 via Wnt", β-catenin, BMC Cancer, pp.2017, 17[DOI]
  39. Fang, Z., "miR‑381 and miR‑489 suppress cell proliferation and invasion by targeting CUL4B via the Wnt", β‑catenin pathway in gastric cancer, 2018, pp.54, 733~743
  40. Xian, X., "miR-23b-3p and miR-130a-5p affect cell growth, migration and invasion by targeting CB1R via the Wnt", β-catenin signaling pathway in gastric carcinoma, 2018, pp.11, 7503~7512
  41. Peng, Y., "Inhibition of miR‑194 suppresses the Wnt", β‑catenin signalling pathway in gastric cancer, 2018, pp.40, 3323~3334
  42. Song, H., "BRD4 promotes the stemness of gastric cancer cells via attenuating miR-216a-3p-mediated inhibition of Wnt", β-catenin signaling, 2019, pp.852, 189~197
  43. Li, Y., "Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt", β-catenin signaling, 2019, pp.19, 505~
  44. Yuan, J., "MIR17HG-miR-18a", 19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt, Cell Death Dis, pp.2019, 10[DOI]
  45. Li, W., "MiR-503 suppresses cell proliferation and invasion of gastric cancer by targeting HMGA2 and inactivating WNT signaling pathway", Cancer Cell Int, 19, pp.164~ (2019)
  46. Jiang, K., "Long non-coding RNA TOB1-AS1modulates cell proliferation, apoptosis, migration and invasion through miR-23a", NEU1 axis via Wnt, Eur. Rev. Med. Pharmacol. Sci, pp.2019, 23[DOI]
  47. Zheng, J., "Hypoxia Activates SOX5", Wnt, Technol. Cancer Res. Treat, pp.2020, 19[DOI]
  48. Ma, B., "Effects of miR-330-3p on Invasion, Migration and EMT of Gastric Cancer Cells by Targeting PRRX1-Mediated Wnt", β-Catenin Signaling Pathway, 2020, pp.13, 3411~3423
  49. Zhou, W., "miR-6838-5p Affects Cell Growth, Migration, and Invasion by Targeting GPRIN3 via the Wnt", β-Catenin Signaling Pathway in Gastric Cancer, 2020, pp.87, 327~337
  50. Guan, B., "LncRNA NCK1-AS1 exerts oncogenic property in gastric cancer by targeting the miR-22-3p", BCL9 axis to activate the Wnt, Environ. Toxicol, pp.2021, 36[DOI]
  51. Iorio, M. V., "MicroRNA profiling as a tool to understand prognosis, therapy response and resistance in breast cancer", Eur. J. Cancer, 44, pp.2753~2759 (2008)
  52. To, K. K, "MicroRNA : a prognostic biomarker and a possible druggable target for circumventing multidrug resistance in cancer chemotherapy", J. Biomed. Sci, 20, pp.99~ (2013)
  53. Robertson, N. M., "The role of microRNA in resistance to breast cancer therapy", Wiley Interdiscip. Rev.: RNA, 5, pp.823~833 (2014)
  54. Dehghanzadeh, R., "MicroRNA-induced drug resistance in gastric cancer", Biomed. Pharmacother, 74, pp.191~199 (2015)
  55. Mihanfar, A., "MicroRNA-mediated drug resistance in ovarian cancer", J. Cell. Physiol, 234, pp.3180~3191 (2017)
  56. Jiao, X., "microRNA : The Impact on Cancer Stemness and Therapeutic Resistance", Cells, 9, pp.8~ (2020)
  57. Guo, Q., "The Role of Exosomal microRNA in Cancer Drug Resistance", Front. Oncol, 10, pp.472~ (2020)
  58. Smolarz, B., "miRNAs in Cancer(Review of Literature)", Int. J. Mol. Sci, 23, pp.2805~ (2022)
  59. Lu, X., "Plasmon-enhanced biosensors for microRNA analysis and cancer diagnosis", Biosens. Bioelectron, 203, pp.114041~ (2022)
  60. Ma, M., "The Role and Mechanism of microRNA-1224 in Human Cancer", Front. Oncol, 12, pp.858892~ (2022)
  61. Zhenshun Cheng, "MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2", Experimental and Molecular Medicine, 46, pp.1~9 (2014), 생화학분자생물학회
  62. Fang Wang, "miR-638 is a new biomarker for outcome prediction of non-small cell lung cancer patients receiving chemotherapy", Experimental and Molecular Medicine, 47, pp.1~8 (2015), 생화학분자생물학회
  63. Radanova, M., "Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis", Biomedicines, 10, pp.156~ (2022)
  64. Liao, Y., "A-to-I RNA editing as a tuner of noncoding RNAs in cancer", Cancer Lett, 494, pp.88~93 (2020)
  65. Kim Hyung Seok, "ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer", Experimental and Molecular Medicine, 55, pp.95~107 (2023), 생화학분자생물학회[DOI]
  66. Meyer Kate, D., "Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons", Cell, 149, pp.1635~1646 (2012)
  67. Pan Xiaoping, "METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner", Experimental and Molecular Medicine, 53, pp.1~12 (2021), 생화학분자생물학회[DOI]
  68. Daoyang Zhou, "DNMT1 mediates chemosensitivity by reducing methylation of miRNA-20a promoter in glioma cells", Experimental and Molecular Medicine, 47, pp.1~11 (2015), 생화학분자생물학회
  69. Misso, G., "Mir-34 : A New Weapon Against Cancer? Mol", Ther. -Nucleic Acids, 3, pp.e194~ (2014)
  70. Rokavec, M., "The p53", miR-34 axis in development and disease, 2014, pp.6, 214~230
  71. Ling, H., "MicroRNAs and other non-coding RNAs as targets for anticancer drug development", Nat. Rev. Drug Discov, 12, pp.847~865 (2013)
  72. Peltier, H. J., "Effects of MRX34, a liposomal miR-34 mimic, on target gene expression in human white blood cells (hWBCs): qRT-PCR results from a first-in-human trial of microRNA cancer therapy", Ann. Oncol, 27, pp.vi531~ (2016)
  73. Hong, D. S., "Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours", Br. J. Cancer, 122, pp.1630~1637 (2020)
  74. Croce, C. M., "Causes and consequences of microRNA dysregulation in cancer", Nat. Rev. Genet, 10, pp.704~714 (2009)
  75. Dong, J. -T., "Loss of heterozygosity at 13q14 and 13q21 in high grade, high stage prostate cancer", Prostate, 49, pp.166~171 (2001)
  76. Cimmino, A., "miR-15 and miR-16 induce apoptosis by targeting BCL2", Proc. Natl Acad. Sci, 102, pp.13944~13949 (2005)
  77. Ramaiah, M. J., "Functions and epigenetic aspects of miR-15", 16 : Possible future cancer therapeutics, 2018, pp.12, 149~164
  78. van Zandwijk, N., "Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma : a first-in-man, phase 1, open-label, dose-escalation study", Lancet Oncol, 18, pp.1386~1396 (2017)
  79. Kalkusova, K., "The Role of miR-155 in Antitumor Immunity", Cancers, 14, pp.5414~ (2022)
  80. Bayraktar, R., "miR-155 in cancer drug resistance and as target for miRNA-based therapeutics", Cancer Metastasis Rev, 37, pp.33~44 (2017)
  81. Witten, L, "miR-155 as a novel clinical target for hematological malignancies", Carcinogenesis, 41, pp.2~7 (2019)
  82. Costinean, S., "Pre-B cell proliferation and lymphoblastic leukemia", highgrade lymphoma in Eμ-miR155 transgenic mice, 2006, pp.103, 7024~7029
  83. Anastasiadou, E., "Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo", Clin. Cancer Res. : Off. J. Am. Assoc. Cancer Res, 27, pp.1139~1149 (2021)
  84. Seto, A. G., "Cobomarsen, an oligonucleotide inhibitor of miR-155, coordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma", Br. J. Haematol, 183, pp.428~444 (2018)
  85. Khordadmehr, M., "miR-193 : A new weapon against cancer", J. Cell. Physiol, 234, pp.16861~16872 (2019)
  86. Ovcharenko, D., "Genome-Scale MicroRNA and Small Interfering RNA Screens Identify Small RNA Modulators of TRAIL-Induced Apoptosis Pathway", Cancer Res, 67, pp.10782~10788 (2007)
  87. Nakano, H., "Gain-of-function microRNA screens identify miR-193a regulating proliferation and apoptosis in epithelial ovarian cancer cells", Int. J. Oncol, 42, pp.1875~1882 (2013)
  88. Wang, J., "MicroRNA-193 Pro-Proliferation Effects for Bone Mesenchymal Stem Cells After Low-Level Laser Irradiation Treatment Through Inhibitor of Growth Family, Member 5", Stem Cells Dev, 21, pp.2508~2519 (2012)
  89. Telford, B. J., "Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology", Oncotarget, 12, pp.422~439 (2021)
  90. van den Bosch, M. T. J., "Transcriptome-wide analysis reveals insight into tumor suppressor functions of 1B3, a novel synthetic miR-193a-3p mimic", Mol. Ther. -Nucleic Acids, 23, pp.1161~1171 (2021)
  91. Tehler, D., "The miR-10 microRNA precursor family", RNA Biol, 8, pp.728~734 (2011)
  92. Ma, L., "Tumour invasion and metastasis initiated by microRNA-10b in breast cancer", Nature, 449, pp.682~688 (2007)
  93. Ma, L., "Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model", Nat. Biotechnol, 28, pp.341~347 (2010)
  94. Yoo, B., "Design of Nanodrugs for miRNA Targeting in Tumor Cells", J. Biomed. Nanotechnol, 10, pp.1114~1122 (2014)
  95. Yigit, M. V., "Magnetic Nanoparticles for Cancer Diagnosis and Therapy", Pharm. Res, 29, pp.1180~1188 (2012)
  96. Weissleder, R., "Polyclonal human immunoglobulin G labeled with polymeric iron oxide : antibody MR imaging", Radiology, 181, pp.245~249 (1991)
  97. Sheedy, P., "The fundamental role of miR-10b in metastatic cancer", Am. J. Cancer Res, 8, pp.1674~1688 (2018)
  98. Liang, L., "A narrative review of microRNA therapeutics : understanding the future of microRNA research", Precis. Cancer Med, 4, pp.33~33 (2021)
  99. Romano, G., "microRNAs as Novel Therapeutics in Cancer", Cancers, 13, pp.1526~ (2021)
  100. "Regulus Announces Clinical Candidate Nomination for the Treatment of Glioblastoma Multiforme" (2017)[URL]
  101. Quirico, L., "The power of microRNAs as diagnostic and prognostic biomarkers in liquid biopsies", Cancer Drug Resist, 3, pp.117~139 (2020)
  102. Zhang, C., "Overview of MicroRNAs as Diagnostic and Prognostic Biomarkers for High-Incidence Cancers in 2021", Int. J. Mol. Sci, 23, pp.11389~ (2022)
  103. Mirahmadi, Y., "MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer", J. Oncol, 2021, pp.1~25 (2021)
  104. Zografos, E., "Prognostic role of microRNAs in breast cancer : a systematic review", Oncotarget, 10, pp.7156~7178 (2019)
  105. Ji, L., "Regulation of small RNA stability : methylation and beyond", Cell Res, 22, pp.624~636 (2012)
  106. Kai, Z. S., "MicroRNA assassins : factors that regulate the disappearance of miRNAs", Nat. Struct. Mol. Biol, 17, pp.5~10 (2010)
  107. O’Brien, J., "Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation", Front. Endocrinol, 9, pp.402~ (2018)
  108. Mitchell, P. S., "Circulating microRNAs as stable blood-based markers for cancer detection", Proc. Natl Acad. Sci, 105, pp.10513~10518 (2008)
  109. Yang, N., "MicroRNAs : Pleiotropic Regulators in the Tumor Microenvironment", Front. Immunol, 9, pp.2491~ (2018)
  110. Hanahan, D., "Hallmarks of cancer: the next Generation", Cell, 144, pp.646~674 (2011)

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