암환자의 항암제 임상시험에 대한 인식과 만족도
Perception and Satisfaction of Anticancer Drug Clinical Trials in Cancer Patients
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Purpose: The purpose of this study was to investigate the perception and satisfaction of cancer patients participating in clinical trials ofanticancer drugs and the factors affecting their satisfaction. Methods: The participants were cancer patients who participated in morethan two cycles of clinical trials at a tertiary hospital in Seoul, Korea. Questionnaires were used to assess the perception and satisfactionof clinical trials of anticancer drugs. Results: A total of 106 patients participated. The average perception and satisfaction regarding clinicaltrials among patients on a 5 point scale was 3.99±0.45 and 4.09±0.55 respectively. There was a significant difference in the correlationamong participants’ perception and their satisfaction (r =.67, p<.001). Regression analysis revealed that satisfaction was explainedby, perception of clinical trials (β =.67, p<.001), participation period 30~59 days (β =.21, p=.009), and participation period over 60 days(β=.20, p=.013). These variables explained 48.7% of the variance of clinical trial satisfaction. Conclusion: The results of this study suggestthat changes in perceptions of clinical trials are needed to improve satisfaction of anticancer drug clinical trials. This can be used asa basis for improving the quality of clinical trials and education programs for cancer patients participating in clinical trials.
Abstract
Purpose: The purpose of this study was to investigate the perception and satisfaction of cancer patients participating in clinical trials ofanticancer drugs and the factors affecting their satisfaction. Methods: The participants were cancer patients who participated in morethan two cycles of clinical trials at a tertiary hospital in Seoul, Korea. Questionnaires were used to assess the perception and satisfactionof clinical trials of anticancer drugs. Results: A total of 106 patients participated. The average perception and satisfaction regarding clinicaltrials among patients on a 5 point scale was 3.99±0.45 and 4.09±0.55 respectively. There was a significant difference in the correlationamong participants’ perception and their satisfaction (r =.67, p<.001). Regression analysis revealed that satisfaction was explained by, perception of clinical trials (β =.67, p<.001), participation period 30~59 days (β =.21, p=.009), and participation period over 60 days(β=.20, p=.013). These variables explained 48.7% of the variance of clinical trial satisfaction. Conclusion: The results of this study suggestthat changes in perceptions of clinical trials are needed to improve satisfaction of anticancer drug clinical trials. This can be used asa basis for improving the quality of clinical trials and education programs for cancer patients participating in clinical trials.
참고문헌 (29)
- "Understanding clinical trial"[URL]
- "Results of clinical trial approval in 2017"[URL]
- "Clinical trial"[URL]
- Paik SS, "Affecting factors on satisfaction of clinical trial subjects", master, pp.2010
- 위계찬, "의약품 임상시험에서 피험자 보호", 의료법학, 13(2), pp.79~113 (2012), 대한의료법학회
- 김현영, "암환자의 신약개발 임상시험 참여 경험", Asian Oncology Nursing, 6(2), pp.121~132 (2006), 대한종양간호학회
- Kim JW, "Cancer patients’ awareness of clinical trials, perceptions on the benefit and willingness to participate: Korean perspectives", Br J Cancer, 99, pp.1593~1599 (2008)
- 임유주, "Korean Cancer Patients’ Awareness of Clinical Trials, Perceptions on the Benefit and Willingness to Participate", Cancer Research and Treatment, 49(4), pp.1033~1043 (2017), 대한암학회
- Mun HR, "A survey of the cognition on clinical trial and informed consent of cancer patients and their families", J Korean Soc Clin Pharmacol Ther, 3, pp.141~153 (1995)
- Mills EJ, "Barriers to participation in clinical trials of cancer: a meta-analysis and systematic review of patient-reported factors", Lancet Oncol, 7, pp.141~148 (2006)
- Hussain-Gambles M, "South Asian patients’ views and experiences of clinical trial participation", Fam Pract, 21, pp.636~642 (2004)
- 김건형, "암 환자의 임상시험 참여 의향과 연관된 요인: 탐색형 서술적 문헌고찰", Journal of Acupuncture Research, 33(3), pp.145~152 (2016), 대한침구의학회
- 김해진, "항암제 임상시험에 참여 중인 암 환자의 불안, 우울과 불확실성", 성인간호학회지, 25(1), pp.53~61 (2013), 한국성인간호학회
- Bos A, "Patient compliance:a determinant of patient satisfaction?", Angle Orthod, 75, pp.526~531 (2005)
- Kim YH, "A survey of the cognition on informed consent in clinical trials with patients who participating to cancer clinical trials", master, pp.2008
- 김지예, "암환자의 임상연구에 대한 인식도 분석: 피험자 보호 관점에서", 한국의료윤리학회지, 16(3), pp.346~360 (2013), 한국의료윤리학회[DOI]
- Lynn MR, "Determination and quantification of content validity", Nurs Res, 35, pp.382~385 (1986)
- 정희정, "침구임상시험 피험자의 참여 동기 및 만족도 조사", Journal of Acupuncture Research, 30(3), pp.109~115 (2013), 대한침구의학회[DOI]
- Ryu BE, "Understanding and satisfaction of clinical trial participants", master, pp.2009
- "Clinical trials"[URL]
- 윤은화, "순환기 약물임상시험 대상자의 서면동의서 이해도와 참여결정후회도", 한국의료윤리학회지, 17(3), pp.237~252 (2014), 한국의료윤리학회[DOI]
- "Kidney cancer"[URL]
- Cainap C, "Linifanib versus Sorafenib in patients with advanced hepatocellular carcinoma:results of a randomized phase III trial", J Clin Oncol, 33, pp.172~179 (2015)
- Cheng AL, "Sunitinib versus sorafenib in advanced hepatocellular cancer: results of a randomized phase III trial", J Clin Oncol, 31, pp.4067~4075 (2013)
- Joffe S, "Quality of informed consent in cancer clinical trials: a cross-sectional survey", Lancet, 358, pp.1772~1777 (2001)
- 강현숙, "국내 연구간호사의 근무여건 및 임상시험업무 특성", 임상간호연구, 9(2), pp.42~55 (2004), 병원간호사회
- Ellis PM, "Attitudes towards and participation in randomised clinical trials in oncology: a review of the literature", Ann Oncol, 11, pp.939~945 (2000)
- Verheggen FW, "Patient satisfaction with clinical trial participation", Int J Qual Health Care, 10, pp.319~330 (1998)
- Wray RJ, "Do cancer patients fully understand clinical trial participation? A pilot study to assess informed consent and patient expectations", J Cancer Educ, 22, pp.21~24 (2007)