Stability and Effectiveness of Laser and Liquiband Treatments in the Rat Model of Oral Ulcer
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Background and ObjectivesThis study was undertaken to assess the stability and efficacy of laser therapy (808 nm), Liquiband (a commercial topical skin adhesive product), and a combination treatment, for application in oral ulcers. Materials and MethodsThe oral ulcer rat animal model was used to determine the efficacy of photobiomodulation, Liquiband, or combination therapy. Ulcers were induced by injecting 60% acetic acid in the oral mucosa. Three days after ulcer confirmation, the chemically induced ulcers were treated with either laser (808 nm), Liquiband, or a combination of both, every two days for 8 days (4 sessions). Combination therapy was performed by first treating with laser followed by application of the Liquiband. Reduction in ulcer area size was subsequently determined, and animals were sacrificed at 5 and 10 days after the last administration, for histological observation of the extracted oral ulcer tissue samples. ResultsIn this study, treatment with either laser (808 nm) or commercial Liquiband product as well as the combined treatment significantly enhanced oral ulcer healing in the rat animal model. The effect of laser treatment is mainly attributed to collagen synthesis, whereas application of the Liquiband promotes vascularization and formation of granulation tissue. Our results indicate that further optimization of the combined therapy could synergistically and significantly enhance oral ulcer healing. ConclusionLaser or Liquiband treatment of oral ulcer in the rat animal model exert different outcomes, but both methods confirm significant effects relative to the untreated group. The combined treatment group with laser and Liquiband showed marked oral ulcer healing, but further optimization is required to get highly significant results and establish the potential synergistic effect of the combination therapy, as compared to the individual enhancing effects of healing oral ulcers.
Abstract
Background and ObjectivesThis study was undertaken to assess the stability and efficacy of laser therapy (808 nm), Liquiband (a commercial topical skin adhesive product), and a combination treatment, for application in oral ulcers. Materials and MethodsThe oral ulcer rat animal model was used to determine the efficacy of photobiomodulation, Liquiband, or combination therapy. Ulcers were induced by injecting 60% acetic acid in the oral mucosa. Three days after ulcer confirmation, the chemically induced ulcers were treated with either laser (808 nm), Liquiband, or a combination of both, every two days for 8 days (4 sessions). Combination therapy was performed by first treating with laser followed by application of the Liquiband. Reduction in ulcer area size was subsequently determined, and animals were sacrificed at 5 and 10 days after the last administration, for histological observation of the extracted oral ulcer tissue samples. ResultsIn this study, treatment with either laser (808 nm) or commercial Liquiband product as well as the combined treatment significantly enhanced oral ulcer healing in the rat animal model. The effect of laser treatment is mainly attributed to collagen synthesis, whereas application of the Liquiband promotes vascularization and formation of granulation tissue. Our results indicate that further optimization of the combined therapy could synergistically and significantly enhance oral ulcer healing. ConclusionLaser or Liquiband treatment of oral ulcer in the rat animal model exert different outcomes, but both methods confirm significant effects relative to the untreated group. The combined treatment group with laser and Liquiband showed marked oral ulcer healing, but further optimization is required to get highly significant results and establish the potential synergistic effect of the combination therapy, as compared to the individual enhancing effects of healing oral ulcers.
참고문헌 (21)
- Lim YS, "Enhanced mucosal healing with curcumin in animal oral ulcer model", Laryngoscope, 126, pp.E68~E73 (2016)
- Wray D, "Role of mucosal injury in initiating recurrent aphthous stomatitis", Br Med J(Clin Res Ed), 283, pp.1569~1570 (1981)
- Jurge S, "Mucosal disease series. Number VI. Recurrent aphthous stomatitis", Oral Dis, 12, pp.1~21 (2006)
- Sircus W, "Recurrent aphthous ulceration of the mouth; a study of the natural history, aetiology, and treatment", Q J Med, 26, pp.235~249 (1957)
- Ship JA, "Recurrent aphthous stomatitis", Quintessence Int, 31, pp.95~112 (2000)
- Basirat M, "The effects of low power lasers in healing of oral ulcers", J Lasers Med Sci, 3, pp.79~83 (2012)
- Khademi H, "Evaluation of low level laser therapy in recurrent aphthous stomatitis", J Dent, 10, pp.160~162 (2009)
- Hamblin MR, "Mechanisms of low level light therapy", Mechanisms for low-light therapy (2006), SPIE
- In Kwon Mun, "Effect of Low-level Laser Therapy on Propylthiouracil-induced Hypothyroidism Model Mice: A Pilot Study", Medical Lasers, 10(1), pp.37~44 (2021), 대한의학레이저학회[DOI]
- Shin Hyuk Yoo, "Effect of Photobiomodulation on the Mesenchymal Stem Cells", Medical Lasers, 9(2), pp.119~125 (2020), 대한의학레이저학회[DOI]
- Penoff J, "Skin closures using cyanoacrylate tissue adhesives. Plastic Surgery Educational Foundation DATA Committee. Device and Technique Assessment", Plast Reconstr Surg, 103, pp.730~731 (1999)
- Farion K, "Tissue adhesives for traumatic lacerations in children and adults", Cochrane Database Syst Rev, (3), pp.CD003326~ (2002)
- Ando M, "Surgical site infection in spinal surgery : a comparative study between 2-octyl-cyanoacrylate and staples for wound closure", Eur Spine J, 23, pp.854~862 (2014)
- Grimaldi L, "Octyl-2-cyanoacrylate adhesive for skin closure : eight years experience", In Vivo, 29, pp.145~148 (2015)
- Nauta A, "Wound healing and regenerative strategies", Oral Dis, 17, pp.541~549 (2011)
- Frantz C, "The extracellular matrix at a glance", J Cell Sci, 123(Pt 24), pp.4195~4200 (2010)
- Shin JM, "Radiofrequency in clinical dermatology", Med Laser, 2, pp.49~57 (2013)
- Young-Koo Kim, "Potential Efficacy of Multiple-shot Long-pulsed 1,064-nm Nd:YAG in Nonablative Skin Rejuvenation: A Pilot Study", Medical Lasers, 9(2), pp.159~165 (2020), 대한의학레이저학회[DOI]
- Miller MF, "A retrospective study of the prevalence and incidence of recurrent aphthous ulcers in a professional population, 1958-1971", Oral Surg Oral Med Oral Pathol, 43, pp.532~537 (1977)
- Neville BW, "Oral and maxillofacial pathology" (2015), Elsevier Health Sciences
- Calderhead RG, "Photobiological basics of photomedicine : a Work of art still in progress", Med Laser, 6, pp.45~57 (2017)