본문 바로가기
KERD
논문KCI 등재

Prevalence of Dental Anomalies in Patients with Non-syndromic Cleft Lip with or without Cleft Palate

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류치의학

초록

This study aimed to assess the prevalence and distribution pattern of dental anomalies in the permanent teeth of patients with non-syndromic cleft lip with or without cleft palate. Additionally, it aimed to compare differences in dental anomalies between cleft and non-cleft areas, considering gender and cleft phenotype. Panoramic radiographs of 164 patients diagnosed with non-syndromic orofacial clefts were retrospectively analyzed by a single examiner to confirm dental anomalies. The dental anomalies investigated included tooth agenesis, supernumerary teeth, microdontia, rotation, ectopic eruption, and enamel hypoplasia. Cleft phenotypes were categorized into 7 types based on medical and dental records. A significantly higher prevalence of supernumerary teeth was observed in males than females within non-cleft areas (p = 0.017), with no significant differences in other dental anomalies. In non-cleft area, patients with cleft palate exhibited a high prevalence of tooth agenesis (p < 0.0001) and microdontia (p = 0.012) compared to other cleft phenotypes. Maxillary incisor rotation was closely associated with adjacent tooth agenesis in unilateral cleft lip and palate cases (p = 0.034). This study suggests that the additional subphenotype based on dental anomalies in patients with orofacial cleft may serve as applicable clinical markers.

Abstract

This study aimed to assess the prevalence and distribution pattern of dental anomalies in the permanent teeth of patients with non-syndromic cleft lip with or without cleft palate. Additionally, it aimed to compare differences in dental anomalies between cleft and non-cleft areas, considering gender and cleft phenotype. Panoramic radiographs of 164 patients diagnosed with non-syndromic orofacial clefts were retrospectively analyzed by a single examiner to confirm dental anomalies. The dental anomalies investigated included tooth agenesis, supernumerary teeth, microdontia, rotation, ectopic eruption, and enamel hypoplasia. Cleft phenotypes were categorized into 7 types based on medical and dental records. A significantly higher prevalence of supernumerary teeth was observed in males than females within non-cleft areas (p = 0.017), with no significant differences in other dental anomalies. In non-cleft area, patients with cleft palate exhibited a high prevalence of tooth agenesis (p < 0.0001) and microdontia (p = 0.012) compared to other cleft phenotypes. Maxillary incisor rotation was closely associated with adjacent tooth agenesis in unilateral cleft lip and palate cases (p = 0.034). This study suggests that the additional subphenotype based on dental anomalies in patients with orofacial cleft may serve as applicable clinical markers.

참고문헌 (44)

  1. Lidral AC, "Genetic factors and orofacial clefting", Semin Orthod, 14, pp.103~114 (2008)
  2. Jaruratanasirikul S, "Cleft lip and", or palate : 10 years experience at a pediatric cleft center in Southern Thailand, 2008, pp.45, 597~602
  3. Mossey PA, "Cleft lip and palate", Lancet, 374, pp.1773~1785 (2009)
  4. Lee CW, "Prevalence of orofacial clefts in Korean live births", Obstet Gynecol Sci, 58, pp.196~202 (2015)
  5. Salari N, "Global prevalence of cleft palate, cleft lip and cleft palate and lip : A comprehensive systematic review and meta-analysis", J Stomatol Oral Maxillofac Surg, 123, pp.110~120 (2022)
  6. Dixon MJ, "Cleft lip and palate : understanding genetic and environmental influences", Nat Rev Genet, 12, pp.167~178 (2011)
  7. da Silva APRB, "Dental anomalies of number in the permanent dentition of patients with bilateral cleft lip : radiographic study", Cleft Palate Craniofac J, 45, pp.473~476 (2008)
  8. Vyas T, "Cleft of lip and palate : A review", J Family Med Prim Care, 9, pp.2621~2625 (2020)
  9. Honein MA, "Maternal smoking and environmental tobacco smoke exposure and the risk of orofacial clefts", Epidemiology, 18, pp.226~233 (2007)
  10. Wilcox AJ, "Folic acid supplements and risk of facial clefts : national population based case-control study", BMJ, 334, pp.464~ (2007)
  11. Ardinger HH, "Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate", Am J Hum Genet, 45, pp.348~353 (1989)
  12. Phan M, "Tooth agenesis and orofacial clefting : genetic brothers in arms?", Hum Genet, 135, pp.1299~1327 (2016)
  13. Leslie EJ, "Genetics of cleft lip and cleft palate", Am J Med Genet C Semin Med Genet, 163, pp.246~258 (2013)
  14. Akcam MO, "Dental anomalies in individuals with cleft lip and", or palate, 2010, pp.32, 207~213
  15. Camporesi M, "Maxillary dental anomalies in children with cleft lip and palate : a controlled study", Int J Paediatr Dent, 20, pp.442~450 (2010)
  16. Tannure PN, "Prevalence of dental anomalies in nonsyndromic individuals with cleft lip and palate : a systematic review and meta-analysis", Cleft Palate Craniofac J, 49, pp.194~200 (2012)
  17. Letra A, "Defining subphenotypes for oral clefts based on dental development", J Dent Res, 86, pp.986~991 (2007)
  18. Menezes R, "Dental anomalies as part of the cleft spectrum", Cleft Palate Craniofac J, 45, pp.414~419 (2008)
  19. Johnson RL, "Human homolog of patched, a candidate gene for the basal cell nevus syndrome", Science, 272, pp.1668~1671 (1996)
  20. Garvey MT, "Supernumerary teeth-an overview of classification, diagnosis and management", J Can Dent Assoc, 65, pp.612~616 (1999)
  21. Stevenson RE, "Human malformations and related anomalies", pp.446~ (2005), Oxford University Press
  22. Yezioro-Rubinsky S, "Dental anomalies in permanent teeth associated with nonsyndromic cleft lip and palate in a group of Colombian children", Cleft Palate Craniofac J, 57, pp.73~79 (2020)
  23. Toutountzakis N, "Ectopic eruption of the maxillary first permanent molar", Orthod Epitheor, 2, pp.117~128 (1990)
  24. Shapira Y, "Maxillary canine-lateral incisor transposition-orthodontic management", Am J Orthod Dentofacial Orthop, 95, pp.439~444 (1989)
  25. Vieira AR, "Oral clefts and syndromic forms of tooth agenesis as models for genetics of isolated tooth agenesis", J Dent Res, 82, pp.162~165 (2003)
  26. Paradowska-Stolarz A, "Dental anomalies in the incisor-canine region in patients with cleft lip and palate-literature review", Dev Period Med, 18, pp.66~69 (2014)
  27. Nagase Y, "Epidemiological analysis of cleft lip and", or palate by cleft pattern, 2010, pp.9, 389~395
  28. Kim NY, "Cleft sidedness and congenitally missing or malformed permanent maxillary lateral incisors in Korean patients with unilateral cleft lip and alveolus or unilateral cleft lip and palate", Am J Orthod Dentofacial Orthop, 130, pp.752~758 (2006)
  29. Baek SH, "Cleft type and Angle’s classification of malocclusion in Korean cleft patients", Eur J Orthod, 24, pp.647~653 (2002)
  30. Hirayama K, "Anatomical studies on the development of the facial artery and its distribution in the cleft lip of the human fetus. Part 1 development of the facial artery in the human fetus on the latter stage of pregnancy", Med J Kagoshima Univ, 1, pp.295~316 (1971)
  31. Menezes C, "Nonsyndromic cleft lip and", or palate : A multicenter study of the dental anomalies involved, 2018, pp.10, E746~E750
  32. Tortora C, "Prevalence of abnormalities in dental structure, position, and eruption pattern in a population of unilateral and bilateral cleft lip and palate patients", Cleft Palate Craniofac J, 45, pp.154~162 (2008)
  33. Mahabob MN, "Prevalence rate of supernumerary teeth among non-syndromic South Indian population : An analysis", J Pharm Bioallied Sci, 4(Suppl 2), pp.S373~S375 (2012)
  34. Al-Kharboush GH, "The prevalence of specific dental anomalies in a group of Saudi cleft lip and palate patients", Saudi Dent J, 27, pp.75~80 (2015)
  35. Tereza GPG, "Tooth abnormalities of number and position in the permanent dentition of patients with complete bilateral cleft lip and palate", Cleft Palate Craniofac J, 47, pp.247~252 (2010)
  36. Lourenço Ribeiro L, "Dental anomalies of the permanent lateral incisors and prevalence of hypodontia outside the cleft area in complete unilateral cleft lip and palate", Cleft Palate Craniofac J, 40, pp.172~175 (2003)
  37. Papaefthymiou P, "Correlation of Dental Anomalies with Cleft Type and Gender in Non-Syndromic Oral Cleft Patients : A Cross-Sectional Study", Cleft Palate Craniofac J, 61, pp.284~294 (2024)
  38. Demirjian A, "A new system of dental age assessment", Hum Biol, 45, pp.211~227 (1973)
  39. Rakhshan V, "Congenitally missing teeth(hypodontia) : A review of the literature concerning the etiology, prevalence, risk factors, patterns and treatment", Dent Res J, 12, pp.1~13 (2015)
  40. Polder BJ, "A meta-analysis of the prevalence of dental agenesis of permanent teeth", Community Dent Oral Epidemiol, 32, pp.217~226 (2004)
  41. Suzuki A, "A longitudinal study of the presence of dental anomalies in the primary and permanent dentitions of cleft lip and", or palate patients, 2017, pp.54, 309~320
  42. Konstantonis D, "A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients", Prog Orthod, 18, pp.20~ (2017)
  43. Mangione F, "Cleft palate with", without cleft lip in French children : radiographic evaluation of prevalence, location and coexistence of dental anomalies inside and outside cleft region, 2018, pp.22, 689~695
  44. Rullo R, "Prevalence of dental anomalies in children with cleft lip and unilateral and bilateral cleft lip and palate", Eur J Paediatr Dent, 16, pp.229~232 (2015)

관련 논문AI추천

Distribution, side involvement, phenotype and associated anomalies of Korean patients with craniofacial clefts from single university hospitalbased data obtained during 1998–2018하정현, Baek Seung-Hak, Cho Il-Sik, Chung Jee Hyeok, Kim Sukwha, Lim Seung-Weon, Yang Il-Hyung, Yim Sunjin대한치과교정학회 · 대한치과교정학회지2020 · 제50권 제6호Common dental anomalies in Korean orthodontic patients: An updateByoul Han, Jaehyun Kim, Ja Hyeong Ku, Jiyoung Oh, Yoon-Ah Kook, Yoonji Kim대한치과교정학회 · 대한치과교정학회지2022 · 제52권 제5호Characterization of phenotypes and predominant skeletodental patterns in pre-adolescent patients with Pierre–Robin sequenceHyeok Joon Lee, Il-Hyung Yang, Il-Sik Cho, Jee Hyeok Chung, Jin-Young Choi, Jong-Ho Lee, Seung-Hak Baek, Sukwha Kim대한치과교정학회 · 대한치과교정학회지2021 · 제51권 제5호Three-dimensional evaluation of midfacial asymmetry in patients with nonsyndromic unilateral cleft lip and palate by cone-beam computed tomography김용일, 박수병, 손우성, Youn-Kyung Choi대한치과교정학회 · 대한치과교정학회지2013 · 제43권 제3호Cone-beam computed tomography assessment of mandibular asymmetry in unilateral cleft lip and palate patientsFaruk Izzet Ucar, Ilknur Veli, Murat Eruz, Tancan Uysal, Torun Ozer대한치과교정학회 · 대한치과교정학회지2011 · 제41권 제6호Prevalence and patterns of tooth agenesis among patients aged 12–22 years: A retrospective studyBasak Kiziltan Eliacik, Cafer Atas, Gunseli Guven Polat대한치과교정학회 · 대한치과교정학회지2021 · 제51권 제5호

이 간행물의 다른 논문 (9건)