난임 치료와 선천성 기형
Infertility Treatment and Congenital Malformations
1
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Over the past 30 years, fertility treatments including fertility enhancing drugs, artificial insemination and in vitro fertilization (IVF) have been revolutionized. Thus, worldwide, more than 5 million children have been born after assisted reproductive technology (ART) and domestically, it was announced that 2.83% of all births in 2011 were associated with financial support from the National Supporting Program for the Subfertile (NSPS) administered by the Korean Ministry of Health and Welfare (KMHW). As more women seek for fertility treatment, there is growing concern about the safety of the methods. In this review, we aim to summarize the literature on the association between fertility treatment and congenital malformations with respect to subfertility, fertility enhancing medications, and different ART methods. To sum up, although ARTs are associated with slight increase in some malformations, it appears that the increase in congenital malformations is due less to ART methods per se than to the biological perturbations that generated the infertility necessitated ART to achieve pregnancy. And no particular organ system seems disproportionately affected. It is often instructive to remind all couples attempting pregnancy that the baseline malformation rate is 2~3%, compared with 3~4% in ART.
Abstract
Over the past 30 years, fertility treatments including fertility enhancing drugs, artificial insemination and in vitro fertilization (IVF) have been revolutionized. Thus, worldwide, more than 5 million children have been born after assisted reproductive technology (ART) and domestically, it was announced that 2.83% of all births in 2011 were associated with financial support from the National Supporting Program for the Subfertile (NSPS) administered by the Korean Ministry of Health and Welfare (KMHW). As more women seek for fertility treatment, there is growing concern about the safety of the methods. In this review, we aim to summarize the literature on the association between fertility treatment and congenital malformations with respect to subfertility, fertility enhancing medications, and different ART methods. To sum up, although ARTs are associated with slight increase in some malformations, it appears that the increase in congenital malformations is due less to ART methods per se than to the biological perturbations that generated the infertility necessitated ART to achieve pregnancy. And no particular organ system seems disproportionately affected. It is often instructive to remind all couples attempting pregnancy that the baseline malformation rate is 2~3%, compared with 3~4% in ART.
참고문헌 (31)
- Aboulghar H, "prospective controlled study of karyotyping for 430 consecutive babies conceived through intracytoplasmic sperm injection", Fertil Steril, 76, pp.249~253 (2001)
- Biljan MM, "The outcome of 150 babies following the treatment with letrozole or letrozole and gonadotropins", Fertil Steril, 84(Suppl 1), pp.S95~S231 (2005)
- Cox GF, "Intracytoplasmic sperm injection may increase the risk of imprinting defects", Am J Hum Genet, 71, pp.162~164 (2002)
- Croen LA, "Young maternal age and congenital malformations: a population-based study", Am J Public Health, 85, pp.710~713 (1995)
- Diamond MP, "NICHD Reproductive Medicine Network. Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility", N Engl J Med, 373(13), pp.1230~1240 (2015)
- El-Chaar D, "Risk of birth defects increased in pregnancies conceived by assisted human reproduction", Fertil Steril, 92(5), pp.1557~1561 (2009)
- Fedder J, "Neonatal outcome and congenital malformations in children born after ICSI with testicular or epididymal sperm: a controlled national cohort study", Hum Reprod, 28(1), pp.230~240 (2013)
- Greenland S, "Clomiphene citrate and neural tube defects: a pooled analysis of controlled epidemiologic studies and recommendations for future studies", Fertil Steril, 64, pp.936~941 (1995)
- Heisey AS, "Surveillance of congenital malformations in infants conceived through assisted reproductive technology or other fertility treatments", Birth Defects Res A Clin Mol Teratol, 103(2), pp.119~126 (2015)
- Jwa J, "Risk of major congenital anomalies after assisted hatching: analysis of three-year data from the national assisted reproduction registry in Japan", Fertil Steril, 104(1), pp.71~78 (2015)
- Källén B, "In vitro fertilization (IVF) in Sweden: risk for congenital malformations after different IVF methods", Birth Defects Res A Clin Mol Teratol, 73, pp.162~169 (2005)
- Källén B, "Congenital malformations in infants born after in vitro fertilization in Sweden", Birth Defects Res A Clin Mol Teratol, 88(3), pp.137~143 (2010)
- Källén B, "Blastocyst versus cleavage stage transfer in in vitro fertilization: differences in neonatal outcome?", Fertil Steril, 94, pp.1680~1683 (2010)
- Klemetti R, "Children born after assisted fertilization have an increased rate of major congenital anomalies", Fertil Steril, 84, pp.1300~1307 (2005)
- Lee GH, "Current status of assisted reproductive technology in Korea, 2011; Committee for Assisted Reproductive Technology, Statistics, Korean Society for Assisted Reproduction.", Clin Exp Reprod Med, 43(1), pp.38~43 (2016)
- Lie RT, "Birth defects in children conceived by ICSI compared with children conceived by other IVF-methods; a meta-analysis.", Int J Epidemiol, 34, pp.696~701 (2005)
- Meijer WM, "Clomiphene and hypospadias on a detailed level: signal or chance?", Birth Defects Res A Clin Mol Teratol, 76(4), pp.249~252 (2006)
- Pelkonen S, "Major congenital anomalies in children born after frozen embryo transfer: a cohort study 1995-2006", Hum Reprod, 29, pp.1552~1557 (2014)
- Pinborg A, "Congenital anomalies after assisted reproductive technology", Fertil Steril, 99(2), pp.327~332 (2013)
- Reefhuis J, "Use of clomiphene citrate and birth defects, National Birth Defects Prevention Study, 1997-2005", Hum Reprod, 26, pp.451~457 (2011)
- Rimm AA, "A metaanalysis of the impact of IVF and ICSI on major malformations after adjusting for the effect of subfertility", J Assist Reprod Genet, 28, pp.699~705 (2011)
- Sagot P, "Similarly increased congenital anomaly rates after intrauterine insemination and IVF technologies: a retrospective cohort study", Hum Reprod, 27, pp.902~909 (2012)
- Seggers J, "Congenital anomalies in offspring of subfertile couples: a registry-based study in the northern Netherlands", Fertil Steril, 103(4), pp.1001~1010 (2015)
- Simpson JL, "Birth defects and assisted reproductive technologies", Semin Fetal Neonatal Med, 19(3), pp.177~182 (2014)
- Sørensen HT, "Use of clomifene during early pregnancy and risk of hypospadias: population based case-control study", Br Med J, 330, pp.126~127 (2005)
- The Practice Committee of the American Society for Reproductive Medicine, "Use of clomiphene citrate in infertile women: a committee opinion", Fertil Steril, 100, pp.341~348 (2013)
- Tulandi T, "Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate", Fertil Steril, 85, pp.1761~1765 (2006)
- Vermeiden JP, "Are imprinting disorders more prevalent after human in vitro fertilization or intracytoplasmic sperm injection?", Fertil Steril, 99(3), pp.642~651 (2013)
- Wen J1, "Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection:a meta-analysis", Fertil Steril, 97, pp.1331~1337 (2012)
- Wikland M, "Obstetric outcomes after transfer of vitrified blastocysts", Hum Reprod, 25, pp.1699~1707 (2010)
- Zhu JL, "Infertility, infertility treatment, and congenital malformations:Danish national birth cohort", Br Med J, 333(7570), pp.679~ (2006)