주산기 암컷 백서의 태아에 방사선피폭에 따른 선천성기형 발생 시 셀레늄과 엽산 혼합물의 방사선 방호효과
Radiation Protective Effect of Selenium and Folic Acid Mixtures in the Development of Congenital Anomalies Following Radiation Exposure to the Fetus of Perinatal Female W hite R ats
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초록
This study is a search for radiation protection effects of radiation exposure on the organogenic period during the prenatal period, which is known to be the most likely to have congenital malformations by radiation exposure. To study the radiation protection for the mixture of selenium that is strong antioxidant and folic acid that is essential vitamin for DNA synthesis, 2 Gy of radiation was irradiated to pregnant female rats. then, after 14 days of fetal birth, observing blood components, SOD(Superoxide Dismutase), histological changes and external malformations. There was a significant protective effect to reduce blood cell damage(p<0.05) in the irradiation group after selenium and folic acid mixture were administered than irradiation group, and the activation of SOD which is antioxidant enzymes was increased. In addition, confirmed the effect of suppressing the expression of apoptosis of small intestinal cells and the reduction of cerebral cortex layer reduction by radiation. thus, it was confirmed that the congenital malformations were reduced as a result of these protective effects. Based on these results, selenium and folic acid mixture may reduce the incidence of congenital malformations, and it will reduce the damage of the fetus caused by the exposure of the organogenic period due to accidents.
Abstract
This study is a search for radiation protection effects of radiation exposure on the organogenic period during the prenatal period, which is known to be the most likely to have congenital malformations by radiation exposure. To study the radiation protection for the mixture of selenium that is strong antioxidant and folic acid that is essential vitamin for DNA synthesis, 2 Gy of radiation was irradiated to pregnant female rats. then, after 14 days of fetal birth, observing blood components, SOD(Superoxide Dismutase), histological changes and external malformations. There was a significant protective effect to reduce blood cell damage(p<0.05) in the irradiation group after selenium and folic acid mixture were administered than irradiation group, and the activation of SOD which is antioxidant enzymes was increased. In addition, confirmed the effect of suppressing the expression of apoptosis of small intestinal cells and the reduction of cerebral cortex layer reduction by radiation. thus, it was confirmed that the congenital malformations were reduced as a result of these protective effects. Based on these results, selenium and folic acid mixture may reduce the incidence of congenital malformations, and it will reduce the damage of the fetus caused by the exposure of the organogenic period due to accidents.
참고문헌 (10)
- 양윤권, "Selenium과 비타민 E 혼합 섭취가 혈중 피로 요인과 심폐기능에 미치는 효과", Physical Activity and Nutrition, 10(1), pp.43~48 (2006), 한국운동영양학회
- Hibbard BM, "Folate and fetal development", Br. J. Obstet. Gynaecol., 100, pp.30~ (1993)
- Effects of Ionizing Radiation on the Developing Embryo and Fetus. a Review. 81-8710, "Hoffman DA", U.S. Dept. of Health and Human Service Publication(F.D.A), ~ (1981)
- United Nations, "Genetic and Somatic Effects of Ionizing Radiation. Report of United Nations Scientific Committee on the Effects of Atomic Radiation to the General Assembly, With Annexes", United Nations, 1~365 (1986)
- Lee WJ, "Radiation-induced Congenital Anomalies in the Rat Fetuses", The Kor. Jour. of Physical Anthropology, 14(2), pp.159~168 (2001)[DOI]
- Pryor WA, "Oxy-radicals and related species: Their formation, lifetime, and reactions", Am. Rev. Rhysiol., 48, pp.657~667 (1986)[DOI]
- Packer L, "The Antioxidant Miracle: Your Complete Plan for Total Health and Healing" (1999), John Wiley & Sons, Inc
- 정세원, "3주간 Vitamin E와 Selenium 섭취가 항산화 효소 활성과 혈중피로요인에 미치는 영향", 한국체육과학회지, 19(1), pp.1127~1138 (2010), 한국체육과학회
- Bamaekers VT, "Cerebral Folate Deficiency", Dev. Med. Child Neurol., 46, pp.843~851 (2004)
- 채은혜, "어미 쥐의 엽산 영양상태가 자손 쥐의 수초기본단백질(Myelin Basic Protein)발현에 미치는 영향", Journal of Nutrition and Health, 40(2), pp.130~137 (2007), 한국영양학회