凉膈散火湯 추출액이 ICR mouse에서의경구 투여 급성독성에 미치는 영향
Acute Toxicity Study on Yangkyuksanhwa-tang in Mice
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1. Objectives The aim of this study is data analysis for acute toxicity and safety of Yangkyuksanhwa-tang. 2. Methods We investigated the acute toxicity for water-extracted Yangkyuksanhwa-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Yangkyuksanhwa-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 ㎎/㎏. 3. Results We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions The data confirmed that Yangkyuksanhwa-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 ㎎/㎏). In conclusion, LD50 of Yangkyuksanhwa-tang was over 5000 ㎎/㎏ and it is very safe to mice.
Abstract
1. Objectives The aim of this study is data analysis for acute toxicity and safety of Yangkyuksanhwa-tang. 2. Methods We investigated the acute toxicity for water-extracted Yangkyuksanhwa-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Yangkyuksanhwa-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 ㎎/㎏. 3. Results We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions The data confirmed that Yangkyuksanhwa-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 ㎎/㎏). In conclusion, LD50 of Yangkyuksanhwa-tang was over 5000 ㎎/㎏ and it is very safe to mice.
참고문헌 (15)
- Lee JM, "Dong-Eui-Su-Se-Bo-Won", pp.86~91 (1986), Haenglim Publishing Co
- Won JS, "Dongeuisasangsinpyeon", pp.20~54 (1974), Jonghapeuiwonsa
- Lo HS, "The effect of Yangkyuk-Sanhwa-Tang on cytokine production in the patients with cerebral infarction", J Sasang Constitutional Med., 16(1), pp.120~129 (2004)
- Cho SW, "Effects of Yangkyuksanhawtang on the allergic contact dermatitis", J Sasang Constitutional Med, 13(3), pp.89~101 (2001)
- 김상진, "중풍으로 유발된 배뇨？배변장애에 양격산화탕을 위졸 한 치험 1례", 대한본초학회지, 18(3), pp.1~8 (2003), 대한본초학회
- 박은경, "노령 흰쥐의 뇌허혈 손상시 양격산화탕이 뇌해마의 신경세포 및 HSP72 발현에 미치는 영향", 동의생리병리학회지, 17(3), pp.791~797 (2003), 대한동의병리학회
- 정성일, "少陽人 당뇨병환자에 凉膈散火湯을 투여한 증례", 동의생리병리학회지, 16(6), pp.37~1313 (2002), 대한동의병리학회
- Kweon DY, "Studies of the regulatory effect of cytokine production in patients with cerebral infarction by Yangkyuksanhwatang", J Sasang Constitutional Med, 12(2), pp.153~161 (2000)
- 마진열, "ICR 마우스를 이용하여 四物湯의 급성 독성에 관한 연구", 대한한의학 방제학회지, 15(2), pp.113~117 (2007), 대한한의학방제학회
- 마진열, "SD 랫드를 이용한 십전대보탕의 급성 독성 연구", 동의생리병리학회지, 22(5), pp.1192~1195 (2008), 대한동의병리학회
- 마진열, "ICR마우스를 이용하여 八物湯의 급성독성에 관한 연구", 대한본초학회지, 22(2), pp.13~16 (2007), 대한본초학회
- 마진열, "SD 랫트를 이용하여 四物湯의 아급성 독성에 관한 연구", 동의생리병리학회지, 22(1), pp.137~141 (2008), 대한동의병리학회
- 마진렬, "SD 랫트를 이용하여 八物湯의 4주 반복투여 독성에 관한 연구", 대한본초학회지, 22(4), pp.59~64 (2007), 대한본초학회
- 마진열, "Mouse(ICR)에 있어서 시험물질 熱多寒少湯 추출액의 급성독성 시험", 사상체질의학회지, 21(1), pp.247~253 (2009), 사상체질의학회
- A notice from 1999-61, "KFDA", Korea Food and Drug Administration, ~ (1999)