太陰調胃湯 추출액이 ICR mouse에서의 경구 투여 급성독성에 미치는 영향
Acute Toxicity Study on Taeeumjowi-tang in Mice
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1. Objectives The aim of this study is to investigate the acute toxicity and safety of Taeeumjowi-tang. 2. Methods We investigated the acute toxicity for water-extracted Taeeumjowi-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Taeeumjowi-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 ㎎/㎏. 3. Results We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions The data confirmed that Taeeumjowi-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 ㎎/㎏). In conclusion, LD50 of Taeeumjowi-tang was over 5000 ㎎/㎏ and it is very safe to mice.
Abstract
1. Objectives The aim of this study is to investigate the acute toxicity and safety of Taeeumjowi-tang. 2. Methods We investigated the acute toxicity for water-extracted Taeeumjowi-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Taeeumjowi-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 ㎎/㎏. 3. Results We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions The data confirmed that Taeeumjowi-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 ㎎/㎏). In conclusion, LD50 of Taeeumjowi-tang was over 5000 ㎎/㎏ and it is very safe to mice.
참고문헌 (16)
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