少陽人 荊防敗毒散 전탕액이 노화쥐의 신장과 비장 세포의 항산화능에 미치는 영향
Anti-Oxidative Effect of Soyangin Hyeongbangpaedok-san Decoction in Kidney and Spleen Cells of Aged Rats
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1. Objectives The purpose of this study is to find out the Anti-Oxidative effects of Soyangin Hyeongbangpaedok-san(HBP) in kidney and spleen cells of aged rats. 2. Methods Aged rats used in this experiment were 6, 52, 68 weeks old. Each age group was divided into three groups again. One group was given no treatment, another group was dosed normal saline and the other group was dosed HBP decoction. The antioxidant effects of HBP decoction were measured by the levels of SOD, GSH, MDA and NO. 3. Results and Conclusions 1) The activity of SOD was significantly increased in kidney cells of 68w-HBP group. Deterioration of the activity of SOD in kidney cells was significantly suppressed according to increasing in age of the week. 2) The level of NO was significantly decreased in kidney cells of 68w-HBP group. Deterioration of The level of NO in kidney cells was significantly suppressed according to increasing in age of the week. 3) The activity of SOD was increased in spleen cells of 52w and 68w-HBP group. 4) The level of GSH was significantly increased in spleen cells of 68w-HBP group.
Abstract
1. Objectives The purpose of this study is to find out the Anti-Oxidative effects of Soyangin Hyeongbangpaedok-san(HBP) in kidney and spleen cells of aged rats. 2. Methods Aged rats used in this experiment were 6, 52, 68 weeks old. Each age group was divided into three groups again. One group was given no treatment, another group was dosed normal saline and the other group was dosed HBP decoction. The antioxidant effects of HBP decoction were measured by the levels of SOD, GSH, MDA and NO. 3. Results and Conclusions 1) The activity of SOD was significantly increased in kidney cells of 68w-HBP group. Deterioration of the activity of SOD in kidney cells was significantly suppressed according to increasing in age of the week. 2) The level of NO was significantly decreased in kidney cells of 68w-HBP group. Deterioration of The level of NO in kidney cells was significantly suppressed according to increasing in age of the week. 3) The activity of SOD was increased in spleen cells of 52w and 68w-HBP group. 4) The level of GSH was significantly increased in spleen cells of 68w-HBP group.
참고문헌 (35)
- 구병삼, "노화방지의학", pp.22~23 (2003), 칼빈서적
- Yoo HJ, "Aging and Endorcine System", J of Korean Society of Endocrinology, 8(1), pp.1~2 (1993)
- 大韓老人病學會, "老人病學", pp.727~740 (2000), 醫學出版社
- 오유진, "활성산소가 질병의 원인이었다", pp.57~58 (1997), 이화문화출판사
- 余月明, "自由基衰老學說 腎虛與衰老及補腎抗衰老硏究", 陜西中醫, 14(4), pp.187~188 (1993)
- Harman, D, "Free radical theory of aging(the free radical disease)", Raven Pr, 7, pp.111~131 (1984)
- Back SR, "The Study on Aging", J of the Korean Society of Oriental Medical Classics., 12(2), pp.175~183 (1999)
- 李濟馬, "東醫壽世保元四象草藁", pp.41~46 (1999), 정담
- Jeong YJ, "A study of preservation of health in the DongyiBogam and Dongyi Soose Bowon Sasang Chobongyun", J of The Society of Sasang Constitutional Medicine, 14(2), pp.25~34 (2002)
- 李濟馬, "東醫壽世保元", pp.153~ (2003), 여강출판사
- 李乙浩, "四象醫學原論", pp.36~380 (1983), 행림출판사
- Kim DS, "An Experimental Study on some Effects of Soyangin-HyeongBangPaedok-San", J of Sasang Constitutional Med, 1(1), pp.171~181 (1989)
- 고지은, "소양인형방패독산의 생쥐 소교세포에서 지질다당질에 의한 cyclooxygenage-2와 inducible nitric oxide synthase 발현에 미치는 영향", 동의생리병리학회지, 21(4), pp.961~966 (2007), 대한동의병리학회
- 이수영, "荊防敗毒散과 獨活地黃湯이 Wistar rat의 老化에 미치는 影響", 사상체질의학회지, 17(3), pp.91~102 (2005), 사상체질의학회
- 전국 한의과대학 사상의학교실, "개정증보 사상의학", pp.52~395 (2004), 집문당
- Bansal VS, "Distribution of selected phospholipid modifying enzymes in rat brain microsomal subfractions prepared by density gradient zonal rotor centrifugation", Neurochem Res, 10(4), pp.439~451 (1985)
- 후지모토 다이사부로, "노화는 왜 일어나는가", pp.143~144 (1991), 전파과학사
- 김숙희, "老化", pp.13~299 (1995), 민음사
- James D.P, "노화와 건강", pp.27~39 (1995), 대한미디어
- Marian V, "Free radicals and antioxidants in normal physiological functions and human disease", The International Journal of Biochemistry & Cell Biology, 39(1), pp.44~46 (2007)
- 한복기, "활성산소와 노화현상", 화학세계, 38(8), pp.48~51 (1998)
- 가와시마 세이이치로, "수명의 비밀을 벗기는 5가지 열쇠", pp.98~100 (2003), 중앙일보미디어 인터내셔널
- 河北醫學院, "靈樞經校釋", pp.355~ (1982), 人民衛生出版社
- 南京中醫學院醫經敎硏組, "黃帝內經靈樞譯釋", pp.337~ (1986), 上海科學技術出版社
- 程士德, "素問註釋匯粹", pp.95~ (1987), 일중사
- Jeong YJ, "A study of preservation of health in the DongyiBogam and Dongyi Soose Bowon Sasang Chobongyun", J of Sasang Constitutional Med, 14(2), pp.30~31 (2002)
- Kim SM, "A Study of preservation of health in the Dongyi Soose Bowon Sasang Chobonguen", J of Sasang Constitutional Med, 12(1), pp.106~107 (2000)
- 김상찬, "방제학", pp.98~ (1999), 영림사
- Jang EC, "Effect of Age on Glucose Metabolism of Skeletal Muscle in Rats", Yeungnam University journal of medicine, 18(1), pp.94~100 (2001)
- Park SG, "An experimental study of driental medicine on cure for dementia", J of Oriental Neuropsychiatry, 9(2), pp.19~35 (1998)
- Murphy MP, "A simple and rapid test of sensorimotor function in the aged rat", Neurobiology of Learning and Memory, 64, pp.181~186 (1995)
- Lyoyd. D, "How to avoid oxygen", Science, 249, pp.286~ (1999)
- 김영곤, "항산화제", pp.6~154 (2004), 여문각
- Sakamoto Y, "Glutathione. 3rd ed", pp.5~ (1989), Scientific
- Ameczua LL, "Nitric oxide synthesized from L-arginine regulates vascular tone in the coronary circulation of the rabbit", Br J Pharmacol, 97, pp.1119~1124 (1989)