삼차신경의 감각신경 손상에 관한 진단, 치료, 재생에 관한 고찰
The dignosis , repair, regeneration of injured sensory part of Trigeminal nerve
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The trigemina1 nerve is the fifth crania1 nerve which are consist of ophtha1mic nerve. maxillary nerve. and mandibu1ar nerve branch. The trigemina1 nerve functions both as the chief nerve of sensation for the face and the motor nerve controlling the muscles of mastication. Prob1ems with the sensory part of the trigemina1 nerve resu1t in pain or 10ss of sensation in the face. Recent1y. the 1l1jUry of trigemina1 nerve including sensory part is increased by trauma. surgica1 procedure 1ike imp1ant. patho1ogic edema. But. nerve 1l1jury show more limited regeneration and repair reaction than any other tissue like skin. bone. vessel. therefore it is necessary that proper diagnosis. repair therapy and basic science research for cellu1ar. genetic regeneration process are converged in clinica1 treatment fie1d. The visua1 ana10gue sca1e and McGill pain questionaire are most common diagnosis method for sensory testing of sensory nerve injury. Depending on the severity of nerve 1l1jUry. it is sometimes impossib1e nerve to recover their function normally by themse1ves. Surgica1 intervention like nerve repair. decompression. nerve graft permit anatomic reconstruction and successfu1 reinnervation. The interruption of the continuity of an axon. such as may occur with nerve 1l1jury or as a resu1t of inflammation. edema. or compression. 1eads to characteristiv cahnges in the carious segments of the neuronal unit. The cellu1ar 1eve1 and mo1ecu1ar 1eve1 change follow axonal injury. microg1ia1 proliferation and activation . reactive astrocyte. synaptic stripping. and functiona1 activation of the 10ca1 vascu1ature are important components of this non neurona1 cellu1ar response. And proinflammatory cytokines such as IL6. regeneration-associated genes (RAGs). Mye1in- associated inhabitors(MAIs) a1so p1ay centra1 ro1e in successfu1 regeneration. Convergence of proper diagnosis. repair intervention and basic science research for regeneration procedure are applied for improve prognosis and qua1ity of life significant1y.
Abstract
The trigemina1 nerve is the fifth crania1 nerve which are consist of ophtha1mic nerve. maxillary nerve. and mandibu1ar nerve branch. The trigemina1 nerve functions both as the chief nerve of sensation for the face and the motor nerve controlling the muscles of mastication. Prob1ems with the sensory part of the trigemina1 nerve resu1t in pain or 10ss of sensation in the face. Recent1y. the 1l1jUry of trigemina1 nerve including sensory part is increased by trauma. surgica1 procedure 1ike imp1ant. patho1ogic edema. But. nerve 1l1jury show more limited regeneration and repair reaction than any other tissue like skin. bone. vessel. therefore it is necessary that proper diagnosis. repair therapy and basic science research for cellu1ar. genetic regeneration process are converged in clinica1 treatment fie1d. The visua1 ana10gue sca1e and McGill pain questionaire are most common diagnosis method for sensory testing of sensory nerve injury. Depending on the severity of nerve 1l1jUry. it is sometimes impossib1e nerve to recover their function normally by themse1ves. Surgica1 intervention like nerve repair. decompression. nerve graft permit anatomic reconstruction and successfu1 reinnervation. The interruption of the continuity of an axon. such as may occur with nerve 1l1jury or as a resu1t of inflammation. edema. or compression. 1eads to characteristiv cahnges in the carious segments of the neuronal unit. The cellu1ar 1eve1 and mo1ecu1ar 1eve1 change follow axonal injury. microg1ia1 proliferation and activation . reactive astrocyte. synaptic stripping. and functiona1 activation of the 10ca1 vascu1ature are important components of this non neurona1 cellu1ar response. And proinflammatory cytokines such as IL6. regeneration-associated genes (RAGs). Mye1in- associated inhabitors(MAIs) a1so p1ay centra1 ro1e in successfu1 regeneration. Convergence of proper diagnosis. repair intervention and basic science research for regeneration procedure are applied for improve prognosis and qua1ity of life significant1y.
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