손상된 얼굴신경의 재생에 관한 고찰
Study on the regeneration of injured motor part of facial nerve
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The fac ial nerve can be damaged by trauma. infection and surgery Injury to this nerve results in multiple dysfunction of muscles of face and ocular adnexa that have cosmetic. functional and psychological impacts on the patients. Although the peripheral nerve system has an ability to regeneration. recovery of nerve is dependent on multiple factors. Despite of advances in surgical technique and a good rate of structural nerve healing. functional recovery of injured nerve remains incomplete. For functional recovery of injured nerve. innovative strat egies which enhance the ability of regeneration are published. In this review. after a brief description of the anatomy and factors contributing to nerve regeneration. we examine the therapy of injured nerve and then survey the recently published strategies . Injured nerve can be treated by surgical methods such as anastomosis. nerve grafting and neural conduits. Surgical interventions can be used for the treatment of severed nerve. Timing of surgery is controversial But recently. it is generally accepted that primary surgery has many advantages . For the functional recovery of nerve. the growth factor and neurotrophic factor can be applied with surgical therapy. The growth factor are Nerve growth factor and Brain-derived growth factor that are released by Schwann cell. For peripheral nerve regeneration. ultrasound. microwave. and LASER have been used to increase regeneration ability and to promote the functional recovery. These physiological therapy induced the thermal effect. the activation of Schwann cell. and the improvement of functional recovery. Phamaco1ogic intervention for nerve regeneration is proposed. The pharmaco1ogic approaches focused on the modu1ation of the Schwann cell that is a crucia1 ro1e of nerve regeneration. These agents are neurotransmitters and neurohormones. Recent1y. gene therapy and use of stem cell for improving regeneration are proposed. Gene therapy is the delivery of therapeutic gene which trans1ated the growth factor or neurotrophic factor to the injured site. The studies on new intervention of using the stem cell which differentiate into Schwann cell-1ike cell is in progress.
Abstract
The fac ial nerve can be damaged by trauma. infection and surgery Injury to this nerve results in multiple dysfunction of muscles of face and ocular adnexa that have cosmetic. functional and psychological impacts on the patients. Although the peripheral nerve system has an ability to regeneration. recovery of nerve is dependent on multiple factors. Despite of advances in surgical technique and a good rate of structural nerve healing. functional recovery of injured nerve remains incomplete. For functional recovery of injured nerve. innovative strat egies which enhance the ability of regeneration are published. In this review. after a brief description of the anatomy and factors contributing to nerve regeneration. we examine the therapy of injured nerve and then survey the recently published strategies . Injured nerve can be treated by surgical methods such as anastomosis. nerve grafting and neural conduits. Surgical interventions can be used for the treatment of severed nerve. Timing of surgery is controversial But recently. it is generally accepted that primary surgery has many advantages . For the functional recovery of nerve. the growth factor and neurotrophic factor can be applied with surgical therapy. The growth factor are Nerve growth factor and Brain-derived growth factor that are released by Schwann cell. For peripheral nerve regeneration. ultrasound. microwave. and LASER have been used to increase regeneration ability and to promote the functional recovery. These physiological therapy induced the thermal effect. the activation of Schwann cell. and the improvement of functional recovery. Phamaco1ogic intervention for nerve regeneration is proposed. The pharmaco1ogic approaches focused on the modu1ation of the Schwann cell that is a crucia1 ro1e of nerve regeneration. These agents are neurotransmitters and neurohormones. Recent1y. gene therapy and use of stem cell for improving regeneration are proposed. Gene therapy is the delivery of therapeutic gene which trans1ated the growth factor or neurotrophic factor to the injured site. The studies on new intervention of using the stem cell which differentiate into Schwann cell-1ike cell is in progress.
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