포유동물에서 등배축 형성 (Dorsoventral axis) 에관한 발생학적 연구

Abstract

Mechanisms that establish the general bcdy plan make use of a relatively small number of signaling pathways shared among all animals. Among vertebrates, differences in the shape or number of skeletal elements, a1tered morphology of epidetmal allpendages, and vat'iation in pigment distribution combine to Ilroduce the majority of what distinguishes one animal from another However the extent to which these 1l8thways cOlltrol finer differences between bαIy regions is not c1ear. Previous studies about development of m8mmaty gland showed interesting aspect of dorsoventral axis fon11ation. ln mice, there are five pairs of mammat)' glands, which develop from on potent line of bOOy, called as "mammary line". This developmental process is similar to tooth developlllent, which develollment from dentition. Mammary lines are 10α‘ted in each ()f mouse show the two lines of the thoracic and inguinal regions of mice bocIy during early developlllent. [n addition, development of mammary gland showed the typical develolll1lent processes and expression pattern of signalling molecules which were examined in development of other epithelial appendages such as looth, feather and hair. ln this study, we will discuss Ule relationship between m<tmlllary gland development and dorsoventral axis fOtnlation with eXllression pattellls of Bmp4, Lψ， Msx1, Ms.ι2， Tbx3 and Tbx15,