손상된 흰쥐 치수조직의 수복과정에 관한 연구

Abstract

To elucidate the origin of odondoblasHike cells during reparative dentin formation, the pulp regeneration process was examined after 1, 3, 7, and 14 days of the dental pulp exposure of the rats by immunohistochemical method using anti-BrdU and anti-TGF-ß1 antibodies The results were as follows: 1. The odondoblasHike cells regenerating i띠 ured dental pulp and dentin are originated from the perivascular cells. 2. Not only the perivascular cells adjascent to the exposed pulp tissue, but a1so the cells at the radicular p띠p proliferated and migrated to the site. 3. The cells proliferated most actively on 7 days after the pulp exposure. 4. TGF-ß1 appeared to enhace the cell differentiation and secretion of the matrix rather than cell proliferation and migration. These results suggest that the odontoblast-like cells are originated from perivascular cells. TGF-ß1 may promote the regeneration of injured dental pulp stimulating differentiation of progenitor I stem cells of dental pulp and secretion of dentin matrix