흰쥐에서 대합치 상실로 인한 치주조직 변화에 관한 조직학적 연구
Histologic study of changes in rat periodontal tissue following antagonist teeth extraction
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The occlusal force ís principal factor in maintaining 야riodontal health and has been concem in influence on periodontal tissue‘ FibrobJast, of which periodontal Jigament mainly comprises, shows high alkaline phosphatase activity, so it couJd be supposed 01 simiJ앙 role to osteoblast. 매so it has been reported that osteoblast secrets factor that differentiates osteoblast and suppresses bone resorption. Previous studies referred to an interchange of coJlagen fiber by fibroblast but there is no report that fibroblast shows tartrate resistant acid phosphatase (TRAP) activity, which can cause of bone destruction. The aim of this study is that we analyse spatially the change of mandibular periondontal tissue including PDL fibrobJast as time elapses in a case of missing maxillary molar. Twenty-three rats were used for this study. A11 right maxillary molars were extracted and after 3, 7, 14 and 21 days, the rats were killed. After observing mesiodistal and buccolingual section of the distobuccal root of lower first molar, and inspecting osteoclasts and PDL fibroblast, we concluded the foJlowing‘ 1. PDL fibroblasts adjacent to bone resorption 앙ea showed positive reaction in TRAP stai띠 ng which indicates osteoclastic specificity 2. There was a positive correlation between osteoclast and the TRAP positive PDL fibrobJast. (r = 0.62402) 3. The antagonist retained group kontroJ group) showed significantly more osteoclasts in both buccal and dist떠 reglOns 4. There were osteoclasts in the mandibuJar buccal cortical bone of the non antagonist group (experimental group) at 3, 7 days, but not after 14 days after extraction of maxillary teeth. 5. Root resorption and αlontoclasts appeared in the buccal root of the controJ group at 7 and 14 days after extraction of maxillary teeth.
Abstract
The occlusal force ís principal factor in maintaining 야riodontal health and has been concem in influence on periodontal tissue‘ FibrobJast, of which periodontal Jigament mainly comprises, shows high alkaline phosphatase activity, so it couJd be supposed 01 simiJ앙 role to osteoblast. 매so it has been reported that osteoblast secrets factor that differentiates osteoblast and suppresses bone resorption. Previous studies referred to an interchange of coJlagen fiber by fibroblast but there is no report that fibroblast shows tartrate resistant acid phosphatase (TRAP) activity, which can cause of bone destruction. The aim of this study is that we analyse spatially the change of mandibular periondontal tissue including PDL fibrobJast as time elapses in a case of missing maxillary molar. Twenty-three rats were used for this study. A11 right maxillary molars were extracted and after 3, 7, 14 and 21 days, the rats were killed. After observing mesiodistal and buccolingual section of the distobuccal root of lower first molar, and inspecting osteoclasts and PDL fibroblast, we concluded the foJlowing‘ 1. PDL fibroblasts adjacent to bone resorption 앙ea showed positive reaction in TRAP stai띠 ng which indicates osteoclastic specificity 2. There was a positive correlation between osteoclast and the TRAP positive PDL fibrobJast. (r = 0.62402) 3. The antagonist retained group kontroJ group) showed significantly more osteoclasts in both buccal and dist떠 reglOns 4. There were osteoclasts in the mandibuJar buccal cortical bone of the non antagonist group (experimental group) at 3, 7 days, but not after 14 days after extraction of maxillary teeth. 5. Root resorption and αlontoclasts appeared in the buccal root of the controJ group at 7 and 14 days after extraction of maxillary teeth.