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Disease models for the functional restoration of the periodontium based on developmental biology

김재영|안창현|안서영|서조영|Nirpesh Adhikari|ARYAL YAM
대한구강해부학회 (The Korean Academy Of Oral Anatomy)|2019.12|대한구강해부학회지 (The Korean Journal of Oral Anatomy)|제40권 제1호|pp. 9-18|DOI 10.35607/kjoa.40.1.201912.002

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참고문헌

키워드

Periodontitis재생Regeneration치주염치은염GingivitisPeriodontiumExperimental model치아주위조직실험기법

초록

The tooth-supporting structures, which are collectively known as the periodontium, are disrupted in periodontal diseases. This disruption could lead to tooth loss at an advanced state. Therefore, the prevention and management of periodontal diseases are necessary to ensure a good quality of life. Different animal models are used to mimic the human periodontal disease conditions and examine the loss of tissues surrounding the teeth. The efficacy of various therapeutic compounds for the healing and regeneration of the disrupted structures were also examined. However, few studies have used animal models to examine the role of signaling molecules during the process of healing and regeneration. Since the signaling molecules play vital roles during the developmental processes, their role in the healing and regeneration of the periodontium must be evaluated based on the knowledge of developmental biology. This review highlights the process of periodontium development together with the role of signaling molecules. Furthermore, the disease conditions disrupting the periodontium and their severe consequences are also discussed. The different disease models commonly used for evaluation of the therapeutics and signaling molecules in periodontal diseases have also been reviewed, suggesting future research with a developmental biology approach in order to regenerate the periodontium.

Abstract

The tooth-supporting structures, which are collectively known as the periodontium, are disrupted in periodontal diseases. This disruption could lead to tooth loss at an advanced state. Therefore, the prevention and management of periodontal diseases are necessary to ensure a good quality of life. Different animal models are used to mimic the human periodontal disease conditions and examine the loss of tissues surrounding the teeth. The efficacy of various therapeutic compounds for the healing and regeneration of the disrupted structures were also examined. However, few studies have used animal models to examine the role of signaling molecules during the process of healing and regeneration. Since the signaling molecules play vital roles during the developmental processes, their role in the healing and regeneration of the periodontium must be evaluated based on the knowledge of developmental biology. This review highlights the process of periodontium development together with the role of signaling molecules. Furthermore, the disease conditions disrupting the periodontium and their severe consequences are also discussed. The different disease models commonly used for evaluation of the therapeutics and signaling molecules in periodontal diseases have also been reviewed, suggesting future research with a developmental biology approach in order to regenerate the periodontium.

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Comparative Approaches and Insights to Animal Models of Periodontitis고정태, 송주한, 전재민, Zhao Wang대한구강생물학회 · International Journal of Oral Biology2025 · 제50권 제1호Molecular mechanisms underlying tooth root development양류, 조의식대한구강해부학회 · 대한구강해부학회지2020 · 제41권 제1호Wnt/β-Catenin 신호조절에 의한 백악질 형성의 이해양진영, 유영재한국치위생과학회 · 치위생과학회지2016 · 제16권 제6호Wnt/β-catenin signaling in cementum formation and homeostasis조의식, 최화정대한구강해부학회 · 대한구강해부학회지2024 · 제45권 제1호Temporal changes of periodontal tissue pathology in a periodontitis animal model엄흥식, 유기연, 윤현필, 이재관, 이종빈, 장범석, 정보현대한치주과학회 · Journal of Periodontal & Implant Science2023 · 제53권 제4호Development of animal experimental periodontitis models김규리, 김태일, 도민재, 박희정, 서태근, 이정순, 이해신, 차세호대한치주과학회 · Journal of Periodontal & Implant Science2013 · 제43권 제4호

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