Effects of Eclipta prostrata Extract and Copper Peptide on Hair Growth Promotion in an Experimental Animal Model
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The present study was carried out to investigate promotional effect of Eclipta prostrata extracts on hair growth in an animal model of mice. There were four experimental groups including distilled water as negative control(NC), 3% minoxidil (MXD) as positive control (PC), Tricomin as copper peptide (PC) and Eclipta prostrata extract (EE) groups. The EE was extracted with ethanol and diluted with distilled water. The 6 week-old C57BL/6 male mice were shaved with an electric clipper and the test materials were topically treated with 0.2 mL per mouse daily for 3 weeks. The hair re-growth was photographically evaluated weekly during the experimental periods. The number of mast cells was counted on the dorsal skin section of mice. The enzymes, alkaline phosphatase (ALP) and -glutamyl transpeptidase (-GT), were determined using an biochemical autoanalyzer. There were no clinical signs in all experimental groups. As the results of photometric analysis, PC, CP and EE groups accelerated hair regrowth significantly faster than that of NC group after treatments for 2-3 weeks (p⁄0.05). PC, CP and EE groups showed a significant decrease in mast cell population compared to NC group. Activities of ALP and -GT were significantly increased in PC and EE groups compared to NC group (p⁄0.05). Taken together, these results suggest that the Eclipta prostrata extract may have hair-growth promoting activity equal to that of MXD or copper peptide.
Abstract
The present study was carried out to investigate promotional effect of Eclipta prostrata extracts on hair growth in an animal model of mice. There were four experimental groups including distilled water as negative control(NC), 3% minoxidil (MXD) as positive control (PC), Tricomin as copper peptide (PC) and Eclipta prostrata extract (EE) groups. The EE was extracted with ethanol and diluted with distilled water. The 6 week-old C57BL/6 male mice were shaved with an electric clipper and the test materials were topically treated with 0.2 mL per mouse daily for 3 weeks. The hair re-growth was photographically evaluated weekly during the experimental periods. The number of mast cells was counted on the dorsal skin section of mice. The enzymes, alkaline phosphatase (ALP) and -glutamyl transpeptidase (-GT), were determined using an biochemical autoanalyzer. There were no clinical signs in all experimental groups. As the results of photometric analysis, PC, CP and EE groups accelerated hair regrowth significantly faster than that of NC group after treatments for 2-3 weeks (p⁄0.05). PC, CP and EE groups showed a significant decrease in mast cell population compared to NC group. Activities of ALP and -GT were significantly increased in PC and EE groups compared to NC group (p⁄0.05). Taken together, these results suggest that the Eclipta prostrata extract may have hair-growth promoting activity equal to that of MXD or copper peptide.
참고문헌 (26)
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