ICU환자에서 Imipenem 내성 Acinetobacter baumannii와 MRSA의 분리 및 항균제 감수성

Abstract

Infections in ICU patients are often due to multiple antibiotic resistant bacteria, such as MRSA and Acinetobacter spp. hnipenem-resistant gram-negative bacilli has been increasingly reported in other countries. The aim of this study was to determine the prevalence of MRSA and Acinetobacter spp. In ICU patients and to compare antimicrobial reisistance of imipenem-resistant and susceptible Acinetobacter isolates. Respiratory specimens were taken from ICU patients in Wonkwang University Hospital in 2000. Antimicrobial susceptibility was tested by NCCLS disk diffusion test and agar dilution test. MRSA and A. baumannii from ICU patients were isolated from 66.7% and 25% of specimens, respectively. Among the 24 ICU patients, 6 A. baumannii isolates were resistant to imipenem by agar dilution test. The MIC range of imipenem for imipenem-resistant A. baumannii was 16-64 μg/ml. Resistance rate of imipenem-resistant A. baumannii to other antibiotics were higher than that of imipenem-susceptible isolates.