Comparison of Cellular Features Diagnostic of Papillary Thyroid Carcinoma in Liquid-Based (Cell Scan 1500TM) Preparations and Conventional Smears
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The study compared the cytological features of papillary thyroid carcinoma (PTC) in liquid-based preparations (LBPs) and conventional Pap (CP) smears from fine needle aspiration (FNA), and assessed the feasibility of LBP using the Cell Scan 1500TM processor on thyroid FNA samples. Thyroid FNA samples were obtained from 883 consecutive patients. Each sample was divided into two and used for LBPs and CP smears. All were screened independently in a double-blind manner. From the 883 cases, 95 cases were diagnosed as PTC in one or both types of preparation (10.8%). PTC was diagnosed via CP smears in 83 cases (87.4%) and via LBPs in 70 cases (73.7%). However, there were differences in categorization between the paired preparations: Twelve (12) PTCs were misinterpreted in CP smears and 25 PTCs in LBPs. There was a significant discrepancy in the rate of detection of the diagnostic features, with LBPs having a lower detection rate. One (1) case (1.2%) of CP smears and 16 cases (22.9%) of LBPs were categorized as unsatisfactory/nondiagnostic in a total of the 95 PTCs. To conclude, the detection rate of the diagnostic features of PTC is lower in Cell Scan 1500TM samples than in CP smears. However, there are some cases in which a diagnosis of PTC is made in LBPs, but not in CP smears. Therefore, definitive cancer diagnosis in thyroid FNA preparations is likely to result from agreement between direct smears and Cell Scan 1500TM preparations.
Abstract
The study compared the cytological features of papillary thyroid carcinoma (PTC) in liquid-based preparations (LBPs) and conventional Pap (CP) smears from fine needle aspiration (FNA), and assessed the feasibility of LBP using the Cell Scan 1500TM processor on thyroid FNA samples. Thyroid FNA samples were obtained from 883 consecutive patients. Each sample was divided into two and used for LBPs and CP smears. All were screened independently in a double-blind manner. From the 883 cases, 95 cases were diagnosed as PTC in one or both types of preparation (10.8%). PTC was diagnosed via CP smears in 83 cases (87.4%) and via LBPs in 70 cases (73.7%). However, there were differences in categorization between the paired preparations: Twelve (12) PTCs were misinterpreted in CP smears and 25 PTCs in LBPs. There was a significant discrepancy in the rate of detection of the diagnostic features, with LBPs having a lower detection rate. One (1) case (1.2%) of CP smears and 16 cases (22.9%) of LBPs were categorized as unsatisfactory/nondiagnostic in a total of the 95 PTCs. To conclude, the detection rate of the diagnostic features of PTC is lower in Cell Scan 1500TM samples than in CP smears. However, there are some cases in which a diagnosis of PTC is made in LBPs, but not in CP smears. Therefore, definitive cancer diagnosis in thyroid FNA preparations is likely to result from agreement between direct smears and Cell Scan 1500TM preparations.
참고문헌 (20)
- Afify AM, "Cytologic artifacts and pitfalls of thyroid fine-needle aspiration using ThinPrep", Cancer (Cancer Cytopathol), 93, pp.179~186 (2001)
- Biscotti CV, "ThinPrep versus conventional smear cytologic preparations in the analysis of thyroid fine-needle aspiration specimens", Am J ClinPathol, 104, pp.150~153 (1995)
- Cavaliere A, "Fine needle aspiration cytology of thyroid nodules: Conventional vs thin layer technique", J Endocrinol Invest, 31, pp.303~308 (2008)
- Cibas ES, "The Bethesda system for reporting thyroid cytopathology", Am J ClinPathol, 132, pp.658~665 (2009)
- Dey P, "Comparison of ThinPrep and conventional preparations on fine needle aspiration cytology material", ActaCytol, 44, pp.46~50 (2000)
- Ellison E, "Psammoma bodies in fine-needle aspirates of the thyroid: predictive value for papillary carcinoma", Cancer, 84, pp.169~175 (1998)
- Frost AR, "Utility of thin-layer preparations in thyroid fine needle aspiration: diagnostic accuracy, cytomorphology, and optimal sample preparation", Cancer (Cancer Cytopathol), 84, pp.17~25 (1998)
- Hutchinson ML, "Cervical cytology automation. Image analysis: a primer for pathologists", pp.309~335 (1994), Reven Press
- Jung CK, "Split sample comparison of a liquid-based method and conventional smears in thyroid fine needle aspiration", ActaCytol, 52, pp.313~319 (2008)
- Ko HM, "Clinicopathologic analysis of fine needle aspiration cytology of the thyroid. A review of 1,613 cases and correlation with histopathologic diagnosis", ActaCytol, 47, pp.727~732 (2003)
- 이중달, "Comparison of Diagnostic Cytomorphology of Atypical Squamous Cells in Liquid-Based Preparations and Conventional Smears", Journal of Pathology and Translational Medicine, 46(4), pp.365~369 (2012), 대한병리학회
- Leung CS, "Comparison of ThinPrep and conventional preparations: nongynecologiccytologic evaluation", DiagnCytopathol, 16, pp.368~371 (1997)
- Ljung BM, "Thyroid fine-needle aspiration: smears versus liquid- based preparations", Cancer (Cancer Cytopathol), 114, pp.144~148 (2008)
- Luu MH, "Improved preoperative definitive diagnosis of papillary thyroid carcinoma in FNAs prepared with both ThinPrep and conventional smears compared with FNAs prepared with ThinPrep alone", Cancer (Cancer Cytopathol), 119, pp.68~73 (2011)
- Michael CW, "Interpretation of fine-needle aspirates processed by the ThinPrep technique: Cytologic artifacts and diagnostic pitfalls", DiagnCytopathol, 23, pp.6~13 (2000)
- Nasuti JF, "Diagnostic value of liquid-based (ThinPrep) preparations in nongynecologic cases", DiagnCytopathol, 24, pp.137~141 (2001)
- Rossi ED, "Diagnostic efficacy of conventional as compared to liquid- based cytology in thyroid lesions: evaluation of 10,360 fine needle aspiration cytology cases", ActaCytol, 53, pp.659~666 (2009)
- Schlinkert RT, "Factors that predict malignant thyroid lesions when fine-needle aspirations “suspicious for follicular neoplasm”", Mayo Clin Proc, 72, pp.913~916 (1997)
- Yassa L, "Long term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation", Cancer (Cancer Cytopathol), 111, pp.508~516 (2007)
- Zhang Y, "Morphologic predictors of papillary carcinoma on fine-needle aspiration of thyroid with ThinPrep preparations", DiagnCytopathol, 24, pp.378~383 (2001)