갑상샘 세침흡인검사의 액상세포검사(SurePathTM)와 고식적 도말검사의 소견 비교
Comparison of Liquid-based (SurePathTM) and Conventional Preparations in Thyroid Fine Needle Aspiration
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background : The aim of this study was to evaluate differences in cytologic findings between conventional preparation (CP) and SurePathTM liquid-based preparation (LBP) in thyroid fine needle aspiration (FNA). Methods : We analyzed cytological features on a total of 182 thyroid FNAs (83 CP and 99 LBP) that were histologically confirmed as nodular hyperplasia (NH) or papillary carcinoma (PAC). Results : LBP was superior in cellular preservation and cellularity than CP. Interestingly, in LBP, cellularity of NH was similarly high compared to that of PAC. The three-dimensional pattern was more prominent in LBP than in CP. The presence of follicle structures was more frequently found in LBP than in CP in the PAC group. Dispersed single cells in the background were more prominent in LBP than in CP. In the PAC group, contrast of the nuclear membrane was more distinctive in CP than in LBP. Conclusions : In thyroid FNA, LBP is better for cellular preservation, cellularity, background and nuclear detail than CP. However, some features in LBP such as high cellularity in NH, prominent dispersed single cells, and frequent follicle patterns were unfamiliar findings in CP. Hence, we should be aware of these cytomorphologic features in LBP to make a proper diagnosis.
Abstract
Background : The aim of this study was to evaluate differences in cytologic findings between conventional preparation (CP) and SurePathTM liquid-based preparation (LBP) in thyroid fine needle aspiration (FNA). Methods : We analyzed cytological features on a total of 182 thyroid FNAs (83 CP and 99 LBP) that were histologically confirmed as nodular hyperplasia (NH) or papillary carcinoma (PAC). Results : LBP was superior in cellular preservation and cellularity than CP. Interestingly, in LBP, cellularity of NH was similarly high compared to that of PAC. The three-dimensional pattern was more prominent in LBP than in CP. The presence of follicle structures was more frequently found in LBP than in CP in the PAC group. Dispersed single cells in the background were more prominent in LBP than in CP. In the PAC group, contrast of the nuclear membrane was more distinctive in CP than in LBP. Conclusions : In thyroid FNA, LBP is better for cellular preservation, cellularity, background and nuclear detail than CP. However, some features in LBP such as high cellularity in NH, prominent dispersed single cells, and frequent follicle patterns were unfamiliar findings in CP. Hence, we should be aware of these cytomorphologic features in LBP to make a proper diagnosis.
참고문헌 (12)
- Belfiore A, "Fine-needle aspiration biopsy of the thyroid", Endocrinol Metab Clin North Am, 30, pp.361~400 (2001)
- Ogilvie JB, "Current status of fine needle aspiration for thyroid nodules", Adv Surg, 40, pp.223~238 (2006)
- Hoda RS, "Non-gynecologic cytology on liquid-based preparations:a morphologic review of facts and artifacts", Diagn Cytopathol, 35, pp.621~634 (2007)
- Zhang Y, "Morphologic predictors of papillary carcinoma on fine-needle aspiration of thyroid with ThinPrep preparations", Diagn Cytopathol, 24, pp.378~383 (2001)
- Michael CW, "Comparison of ThinPrep and TriPath PREP liquid-based preparations in nongynecologic specimens:a pilot study", Diagn Cytopathol, 25, pp.177~184 (2001)
- Tulecke MA, "ThinPrep for cytologic evaluation of follicular thyroid lesions:correlation with histologic findings", Diagn Cytopathol, 30, pp.7~13 (2004)
- Jung CK, "Split sample comparison of a liquid-based method and conventional smears in thyroid fine needle aspiration", Acta Cytol, 52, pp.313~319 (2008)
- 김동훈, "초음파 유도 갑상샘 세침흡인 세포검사에서 SurePathTM 액상세포검사의 유용성; 고식적 도말검사와 SurePathTM 액상세포검사와의 비교", 대한세포병리학회지, 18(2), pp.143~152 (2007), 대한세포병리학회
- Veneti S, "Liquid-based cytology in breast fine needle aspiration.",Comparison with the conventional smear", Acta Cytol, 47, pp.188~192 (2003)
- Bignold LP, "Hypothesis for the influence of fixatives on the chromatin patterns of interphase nuclei,based on shrinkage and retraction of nuclear and perinuclear structures", Br J Biomed Sci, 59, pp.105~113 (2002)
- Powers CN, "Diagnosis of infectious diseases:a cytopathologist’s perspective", Clin Microbiol Rev, 11, pp.341~365 (1998)
- Lu DY, "High-grade urothelial carcinoma:comparison of SurePath liquid-based processing with cytospin processing", Diagn Cytopathol, 37, pp.16~20 (2009)