뇌졸중 환자의 재활치료가 면역세포와 Cortisol에 미치는 영향
The Effects of Rehabilitation Treatment on the Immune Cells and Cortisol Levels of Stroke Patients
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초록
본 연구의 목적은 뇌졸중 환자가 병원 내 재활운동 프로그램을 통해서 지속적으로 운동 시에 면역세포(T cell, B cell, NK cell) 등이 면역력 향상에 미치는 영향을 구명하고, 생리적 스트레스 반응의 지표인 혈청 Cortisol이 스트레스를 줄이는데 효과가 있는지 보고자 하였다. 연구 대상은 2013년 3월 2일부터 2015년 2월 28일까지 2년간 실시하였으며, 실험군으로는 광주에 있는 S대 병원과 C병원의 뇌졸중 환자 13명, 대조군으로는 일반인(학생, 주부, 직장인) 12명을 선정하여 총 25명을 대상으로 연구하였다. 본 연구 결과는 T cell의 실험군에서는 69.18±11.78%, 대조군에서는 70.75±6.33%로써 통계적으로 실험군과 대조군의 유의한 차이는 없었다. 한편 B cell의 실험군에서는 12.95±3.74%이고 대조군에서는 16.27±3.49%로써 실험군과 대조군의 유의한 차이를 보였다. NK cell의 실험군에서는 21.98±8.98% 대조군에서는 15.72±5.07%로써 NK cell의 비율이 통계상 유의하게 증가하지 않았지만 (p<0.05), 실험군에서 수치가 증가하였음을 알 수 있었다. Cortisol은 실험군 운동전 13.65±6.85% 실험군 운동 후 9.90±4.66%, 대조군 운동전 11.635±4.02% 대조군 운동 후 12.64±2.30% 대조군에서는 두 군의 차이가 유의하지 않았으나, 실험군에서는 유의하게 증가하였다 (p<0.05). 본 연구에서도 병원 내 재활운동 프로그램을 통해서 지속적인 운동으로 면역세포 중 NK cell의 실험군의 전후 차와 T cell에서 실험군의 전후 차가 증가하여 면역력 향상에 영향이 있고, Cortisol의 실험군의 전후 차는 감소하여 스트레스를 줄이는데 효과가 있음을 알 수 있었다.
Abstract
The purpose was to investigate the effects of exercise through an in-hospital rehabilitation exercise program on the enhanced immunity of immune cells and on the reduction of serum cortisol, an indicator of physiological stress responses, among stroke patients. The 25 subjects were put to the program for two years from March 2, 2013 to February 28, 2015. The experiment group included 13 stroke patients from S and C Hospital in Gwangju, and the control group did 12 common people. The findings were as follows: there were no significant differences in T cells between the experiment group of 69.18±11.78% and the control group of 70.75±6.33%; there were significant differences in B cells between the experiment group of 12.95±3.74% and the control group of 16.27±3.49%; and there were no statistically significant increases of NK cells between the experiment group of 21.98±8.98% and the control group of 15.72±5.07% (p<0.05), but the experiment group did rise. While there were increases in cortisol be fore exercise in the experiment group (p<0.05), which recorded 13.65±6.85% before and 9.90±4.66% after, there were no differences after exercise in the control group, which recorded 11.635±4.02% before and 12.64±2.30% after. The present study also found continuous exercise through an in-hospital rehabilitation exercise program increased differences in NK and T cells before and after exercise in the experiment group and thus had effects on enhanced immunity. Meanwhile, differences in cortisol before and after exercise in the experiment group decreased, which indicates that the continuous exercise was effective for reducing stress.
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