대한민국 고혈압 성인에서 아스파르트산 아미노전이효소/알라닌 아미노전이효소 비율과 맥압의 관련성
The Relationship between the Serum Aspartate Aminotransferase/Alanine Aminotransferase Ratio and Pulse Pressure in Korean Adults with Hypertension
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초록
본 연구는 고혈압이 있는 대한민국 성인에서 아스파르트산아미노전이효소(aspartate aminotransferase, AST)/알라닌아미노전이효소(alanine aminotransferase, ALT) 비율과 맥압(pulse pressure, PP) 사이의 관계를 평가하기 위해 수행되었다. 제6차 국민건강영양조사(KNHANES VI–3, 2015)에서성인 1,515명의 데이터를 분석했다. 본 연구에서는 몇 가지 중요한 결과가 있다. 첫째, AST (odds ratio [OR], 1.018; 95% confidence interval [CI], 1.002∼1.033), ALT (OR, 0.982; 95% CI, 0.969∼0.996) 및 AST/ALT ratio (OR, 1.367; 95% CI, 1.027∼1.819)는 고PP 결정하는 독립적인 요인이었다. 둘째, 관련변수(연령, 성별, 흡연, 음주, 규칙적인 운동, TC, TG, HDL-C, FBG, BMI, WC)를 조정한 후의 결과에서 AST/ALT ratio의 1 사분위에 대한 고PP의 OR을 기준으로, AST/ALT ratio의 2 사분위(OR, 1.188; 95% CI, 0.817∼1.727) 및AST/ALT ratio의 3 사분위(OR, 1.169; 95% CI, 0.800∼ 1.710)는 유의하지 않았지만, AST/ALT ratio의 4 사분위(OR, 1.632, 95% CI, 1.113∼2.393)에서 유의하게 높았다. 결론적으로, 고혈압이 있는 대한민국 성인에서 고PP은 AST/ALT ratio 및 AST와 양의 상관관계가 있었지만 ALT와 음의 상관계가 있었다.
Abstract
The present study was conducted to assess the relationship between aspartate aminotransferase/ alanine aminotransferase (AST/ALT) ratio and pulse pressure in Korean adults with hypertension. Data from 1,515 adults from the sixth Korean National Health and Nutrition Examination Survey (KNHANES VI–3, 2015) were analyzed. There were several key findings in the present study. First, aspartate aminotransferase (odds ratio [OR], 1.018; 95% confidence interval [CI], 1.002 to 1.033), alanine aminotransferase (OR, 0.982; 95% CI, 0.969 to 0.996), and aspartate aminotransferase/ alanine aminotransferase ratio (OR, 1.367; 95% CI, 1.027 to 1.819) were the independent factors determining high pulse pressure. Second, after adjusting for related variables [age, gender, smoking, alcohol consumption, regular exercise, total cholesterol (TC), triglycerides (TGs), high-density lipoprotein-cholesterol (HDL-C), fasting plasma glucose (FPG), body mass index (BMI), and waist circumference (WC)], the ORs of high pulse pressure with the 1st quartile as a reference were significantly higher in the 4th quartile of aspartate aminotransferase/alanine aminotransferase ratio [1.632 (95% CI, 1.113∼2.393)]. The high pulse pressure was positively associated with aspartate aminotransferase and alanine aminotransferase/alanine aminotransferase ratio in Korean adults with hypertension, but was inversely associated with alanine aminotransferase.
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