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논문KCI 등재

2015∼2020년 동안 인천 지역 단일기관에서의 비결핵항산균 분포 및 항균제 내성률

Distribution and Antimicrobial Resistance of Non-Tuberculous Mycobacteria during 2015∼2020: A Single-Center Study in Incheon, South Korea

이혜영|주효진|박현환|Jiwoo Kim|Jehyun Koo|Kyungcheol Song|Jayoung Kim
대한임상검사과학회 (Korean Society for Clinical Laboratory Science)|2021.09|대한임상검사과학회지 (Korean Journal of Clinical Laboratory Science)|제53권 제3호|pp. 225-232|DOI 10.15324/kjcls.2021.53.3.225

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IncheonCo-infectionNon-tuberculous mycobacteriaDrug-resistant
주제분류기타자연과학

초록

본 연구는 인천지역에 위치한 단일기관의 비결핵항산균의 분포 및 항균제 내성률과 동반 세균 빈도를 조사한 것으로, 2015 년부터 2020년까지 TB/NTM real-time PCR 검사가 의뢰된8,258건의 환자 데이터를 후향적으로 검토하였다. 총 296건의검체가 NTM 양성이었고, 발생률은 2015년 2.5% (30/1,209) 에서 2020년 3.8% (66/1,740)로 증가하였다. NTM으로 확인된 296건 중, 54.7% (162/296)는 M. avium complex (MAC)에 속하는 균종으로 확인되었고, 그다음으로 M. abscessus complex (MABC) 20.9% (62/296), M. fortuitum 6.4% (19/296) 및 M. flavescens 3.4% (10/296) 순이었다. NTM 양성 검체 중, 약제내성검사가 의뢰된 검체는 76.7% (227/296) 였다. 다제내성 NTM은 40.1% (91/227)였고, 광범위 내성NTM은 59.9% (136/227)였다. NTM과 동시 감염은 43.4% (63/145)이었고 가장 흔한 균종은 Klebsiella pneumonia (23.8%, 15/63)였다. 본 연구는 인천지역의 NTM 분포 및 항균제 내성률과 동반 세균 빈도에 관한 최초 보고이다. NTM 감염의 비율은 점차적으로 증가하는 추세이며 효과적인 관리를 위해적극적인 진료와 철저한 감염관리가 필요할 것이다.

Abstract

This study sought to investigate the distribution, antimicrobial resistance rate, and bacterial co-infection frequency of non-tuberculous mycobacteria (NTM) in a single center in Incheon, South Korea. A total of 8,258 specimens submitted for tuberculosis (TB)/NTM real-time PCR tests during the years 2015 to 2020 were retrospectively reviewed. In total, 296 specimens (3.6%) were NTM positive, and the positivity increased from 2.5% (30/1,209) in 2015 to 3.8% (66/1,740) in 2020. Of 296 NTM specimens, 54.7% (162/296) were identified as the Mycobacterium avium complex (MAC) followed by the Mycobacterium abscessus complex (MABC) 20.9% (62/296), M. fortuitum 6.4% (19/296) and M. flavescens 3.4% (10/296). Of the NTM-positive specimens, 76.7% (227/296) were tested for drug resistance. The results showed multidrug-resistant NTM in 40.1% (91/227) and extensively drug-resistant NTM in 59.9% (136/227) of these specimens. Of the 145 isolates taken for bacterial culture, bacteria/fungi co-infection with NTM accounted for 43.4% (63/145), in which the most common bacterial species was Klebsiella pneumonia (23.8%, 15/63). This study is the first report on the distribution and antimicrobial resistance of NTM in Incheon. As the proportion of NTM infections increases, active treatment and thorough infection control are required for effective management.

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관련 논문AI추천

Continued Upward Trend in Non-Tuberculous Mycobacteria Isolation over 13 Years in a Tertiary Care Hospital in Korea어영, 김영근, 안광진, 조현미, 황규열연세대학교의과대학 · Yonsei Medical Journal2021 · 제62권 제10호최근 2년간 호흡기 검체에서 분리된 비결핵 항산균 분포와 임상적 의의김경희, 김진용, 박정웅, 박필환, 서일혜, 안정열, 이민경, 정지훈대한임상미생물학회 · Annals of Clinical Microbiology2012 · 제15권 제3호호흡기 검체에서의 비결핵 항산균 분리율곽나은, 김건한, 윤은정, 정석훈, 주영선대한임상미생물학회 · Annals of Clinical Microbiology2019 · 제22권 제3호대구지역 한 대학병원에서 비결핵 항산균의 미생물학적 분포 및 임상적 특성신경철, 안준홍, 이관호, 정진홍, 진현정, 최은영, 홍경수영남대학교 의과대학 · Journal of Yeungnam Medical Science2015 · 제32권 제2호Recent Trends in Clinically Significant Nontuberculous Mycobacteria Isolates at a Korean General Hospital김영아, 김현수, 선영규, 이상선, 이양순대한진단검사의학회 · Annals of Laboratory Medicine2014 · 제34권 제1호최근 10년간 광주 2차병원의 호흡기검체에서 분리된 비결핵항산균의 폐질환 유병률에 대한 연구백해경대한임상검사과학회 · 대한임상검사과학회지2020 · 제52권 제4호

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