Total antioxidant status(TAS) 참고치 및 고콜레스테롤혈증, 당뇨병과의 관련성에 관한 연구

Abstract

The Object of this study is to investigate the reference ranges of total antioxidant status(TAS) according to age and sex in korea. The human body is constantly under attack from free radicals. Free radicals are highly reactive molecules and once formed, attack cell structures with the body. As a result, free radicals have been implicated in numerous disease. In healthy individuals, the antioxidant system defends tissues against free radical attack. We measured the total antioxidant status of 90 normal group, 30 diabetes group and 30 hypercholesterolemia group. (The each group sex ratio : half to half) For each test, age and sex related variations were assessed and reference values were estimatedfor three different age groups.(below 20, 21-40, above 41) TAS measured by Randox Total Antioxidant reagent and Hitachi 7150. The reference values according to age were 0.930∼1.332mmolfL in below 20 years of age, 1.007∼1.391mmol⁄L in 21∼40 years of age and 0.995∼1.295mmolfL inabove 41 year of age and showed statistically significant difference.(P<0.05) The Reference ranges of total age group, male and female group were 0.991∼1.343mmolfL, 1.038∼1.370mmol⁄L, and 0.977∼1.285mmolfL respectively. Between the male and female group were statistically significant difference.(P<0.05)The TAS means of diabetes and hypercholesterolemia were 1.26mmol⁄L and 1.23mmol⁄L respectively. TAS values of hypercholerterolemia an normal group were no significant difference whereas diabetes and normal group were significant difference.(P<0.001). We established that reference ranges were analyzed age and sex related variationsfor total antioxdant status. Between experimental groups showed generally significant differences. In the future, correct diagnosis of disease induced free radicals need to measure total antioxidant level and each antioxidants.