산화적 스트레스와 산화적 마커 사이의 관계
The Relationship between Oxidative Stress and Oxidative Markers
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Metabolic syndrome such as, hypertension, diabetes, obesity, dyslipidemia etc are well known lifestyle diseases which threaten a health state. The purpose of this study is to evaluate antioxidant status and reactive oxygen species (ROS) in various stressful conditions. A group of persons (n=28) were enrolled in this study and stress status was evaluated using questionnaire of psychological well-being index (PWI-SF) and hematologic analysis of free oxygen radical defense (FORD), free oxygen radical test (FORT), lipid profiles and serum cortisol level. Analysis was done according to stress index, BMI status and overtime working. Blood samples from diabetics were used for control. Results are as in followings: Higher PWI-SF group showed higher FORT. Obese persons with BMI＞ 25 kg/m2 showed statistically lower FORD (p＜0.05) and higher FORT level (p＜0.01). When compare with diabetics, an overweight group had similar levels in FORD and FORT while a normal body weight group showed quite different with diabetics in FORD (p＜0.001). Higher ROS group has higher triglyceride, CRP and insulin levels but lower in FORD and HDL-cholesterol levels. Overtime working at night showed no meaningful result against our expectations. These results suggested that obesity showed most unfavorable correlations in an antioxidant status in various situations.
Abstract
Metabolic syndrome such as, hypertension, diabetes, obesity, dyslipidemia etc are well known lifestyle diseases which threaten a health state. The purpose of this study is to evaluate antioxidant status and reactive oxygen species (ROS) in various stressful conditions. A group of persons (n=28) were enrolled in this study and stress status was evaluated using questionnaire of psychological well-being index (PWI-SF) and hematologic analysis of free oxygen radical defense (FORD), free oxygen radical test (FORT), lipid profiles and serum cortisol level. Analysis was done according to stress index, BMI status and overtime working. Blood samples from diabetics were used for control. Results are as in followings: Higher PWI-SF group showed higher FORT. Obese persons with BMI＞ 25 kg/m2 showed statistically lower FORD (p＜0.05) and higher FORT level (p＜0.01). When compare with diabetics, an overweight group had similar levels in FORD and FORT while a normal body weight group showed quite different with diabetics in FORD (p＜0.001). Higher ROS group has higher triglyceride, CRP and insulin levels but lower in FORD and HDL-cholesterol levels. Overtime working at night showed no meaningful result against our expectations. These results suggested that obesity showed most unfavorable correlations in an antioxidant status in various situations.
참고문헌 (25)
- Alberti KG, "Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation", Diabet Med, 15(7), pp.539~553 (1998)
- Conner GE, "Lactoperoxidase and hydrogen peroxide metabolism in the airway", Am J Respir Crit Care Med, 166(12 Pt 2), pp.S57~S61 (2002)
- Costford SR, "Increased susceptibility to oxidative damage in post-diabetic human myotubes", Diabetologia, 52(11), pp.2405~2415 (2009)
- Devasagayam TP, "Ghaskadbi SS, Lele RD. Free radicals and antioxidants in human health: current status and future prospects", J Assoc Physicians India, 52, pp.794~804 (2004)
- Furukawa S, "Increased oxidative stress in obesity and its impact on metabolic syndrome", J Clin Invest, 114(12), pp.1752~1761 (2004)
- Giacco F, "Oxidative stress and diabetic complications", Circ Res, 107(9), pp.1058~1070 (2010)
- Hansel B, "Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity", J Clin Endocrinol Metab, 89(10), pp.4963~4971 (2004)
- Haslam DW, "Obesity", Lancet, 366(9492), pp.1197~1209 (2005)
- Hey-Mogensen M, "Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes", Diabetologia, 53(9), pp.1976~1985 (2010)
- Isomaa B, "Cardiovascular morbidity and mortality associated with the metabolic syndrome", Diabetes Care, 24(4), pp.683~689 (2001)
- James PT, "The obesity epidemic, metabolic syndrome and future prevention strategies", Eur J Cardiovasc Prev Rehabil, 11(1), pp.3~8 (2004)
- Jialal I, "Role of C-reactive protein in the assessment of cardiovascular risk", Am J Cardiol, 91(2), pp.200~202 (2003)
- Kelley DE, "Fuel selection in human skeletal muscle in insulin resistance: a reexamination", Diabetes, 49(5), pp.677~683 (2000)
- "Disease Trends "Metabolic disease is increasing while cancer decreases" (2011)[URL]
- In-depth analyses for metabolic syndrome with data of the 3rd Korea National Health and Nutrition Examination Survey(2005), "Korea Centers for Disease Control and Prevention", 205~238 (2007)
- 권세영, "인슐린 저항과 B세포 기능이 당뇨병이 없는 성인의 항상성 모델 평가에 의해 결정되는 것에 대한 상대적 요인", 대한임상검사과학회지, 45(4), pp.131~138 (2013), 대한임상검사과학회
- Pearson TA, "Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association", Circulation, 107(3), pp.499~511 (2003)
- Pepys MB, "C-reactive protein: a critical update", J Clin Invest, 111(12), pp.1805~1812 (2003)
- Ridker PM, "Clinical application of C-reactive protein for cardiovascular disease detection and prevention", Circulation, 107(3), pp.363~369 (2003)
- 서민정, "한국 소아와 청소년에서 대사증후군의 유병률", Korean Journal of Family Medicine, 27(10), pp.798~806 (2006), 대한가정의학회
- Shamsuzzaman AS, "Elevated C-reactive protein in patients with obstructive sleep apnea", Circulation, 105(21), pp.2462~2464 (2002)
- Sims EA, "Endocrine and metabolic effects of experimental obesity in man", Recent Prog Horm Res, 29, pp.457~496 (1973)
- United Nations, "Statistics on Population Ageing", United Nations press release, ~ (2005)
- Wannamethee SG, "Weight change and duration of overweight and obesity in the incidence of type 2 diabetes", Diabetes Care, 22(8), pp.1266~1272 (1999)
- WHO, "Obesity: preventing and managing the global epidemic. Report of a WHO consultation", World Health Organ Tech Rep Ser, 894, pp.1~253 (2000)