H. pylori 감염 진단 시 14C-요소호기검사의 임상적 유용성

Abstract

Helicobacter pylori (H. pylori) infection is common in korea and high incidence at gastric ulcer and duodenal ulcer. 14C-urea breath test (14C-UBT) is regarded as a highly reliable and non-invasive method for the diagnosis of H. pylori infection. The purpose of this study was to evaluate the diagnositc performance of a new and rapid 14C-UBT, which was equipped with Geiger-Muller counter and compared the results with those obtained by gastroduodenoscopic biopsies (GBx). One hundred sixty-eight patients (M : F = 118 : 50) underwent 14C-UBT, rapid urease test (CLO test), and GBx. The results of 14C-UBT were classified as positive (>50 cpm), borderline (25<p<50 cpm), or negative (<25 cpm) and CLO tests were classified as positive or negative according to color change. The results of GBx on giemsa stain were distribution of H. pylori by the Wyatt method. We compared 14C-UBT or CLO test results with GBx as a glod standard. In the assessment of the presence of H. pylori infection, the 14C-UBT global performance yielded positive predictive value, negative predictive value and accuracy of 93.3% and 83.3%, respectively. However, the CLO test had performance yielded positive predictive value, negative predictive value and accuracy of 76.9%, 50.0%, respectively. In this study 14C-UBT is a highly accurate, simple and non-invasive method or the diagnosis of follow up H. pylori infection.