자연 유산 수태산물의 세포유전학적 분석
A Cytogenetic Analysis of Abortus with Spontaneous Abortion
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
.
Abstract
Chromosomal abnormalities of abortus have also been used to investigate the most common etiology of spontaneous abortion, but the frequency and the types of spontaneous abortions have also demonstrated considerable variation among in different countries and races. A cytogenetic analysis of 75 abortuses was performed at the GenDix, Inc. from January, 2006 to December, 2007. The frequency of chromosome abnormalities in abortus was 32.0% (24/75 cases). Among the chromosomal abnormalities, trisomy was 62.5% (15/24 cases) and the most frequent trisomy was trisomy 21 with 26.6% (4/15 cases). The average maternal age of normal and abnormal karyotypes was 34.1±3.3 and 34.3±3.3. Cytogenetic analysis of abortus is important for diagnosis and genetic counseling for parents with spontaneous abortion.
참고문헌 (9)
- Bricker L, "Types of pregnancy loss in recurrent miscarriage : implications for research and clinical practice", Hum Reprod, 17, pp.1345~1350 (2002)
- Eiben B, "Cytogenetic analysis of 750 spontaneous abortions with the direct-preparation method of chorionic villi and its implications for studying genetic causes of pregnancy wastage", Am J Hum Genet, 47, pp.656~663 (1990)
- Ford JH, "A 13-year cytogenetic study of spontaneous abortion : clinical applications of testing", Aust N Z J Obstet Gynaecol, 36, pp.314~318 (1996)
- Griebel CP, "Management of spontaneous abortion", Am Fam Physician, 72, pp.1243~1250 (2005)
- Pezeshki K, "Bleeding and spontaneous abortion after therapy for infertility", Fertil Steril, 74, pp.504~508 (2000)
- Qumsiyeh MB, "Cytogenetics and mechanisms of spontaneous abortions : increased apoptosis and decreased cell proliferation in chromosomally abnormal villi", Cytogenet Cell Genet, 88, pp.230~235 (2000)
- Sato K, "Clinical course of early fetal loss and its chromosomal characteristics", Asia Oceania J Obstet Gynaecol, 18, pp.131~138 (1992)
- Shelton AJ, "Association between familial autoimmune diseases and recurrent spontaneous abortions", Am J Reprod Immunol, 32, pp.82~87 (1994)
- Stirrat GM, "Recurrent miscarriage; definition and epidemiology", Lancet, 348, pp.1402~1406 (1990)
