사무직 여성의 비만요인에 따른 NK세포 활성도 관계 연구
A Study on the Relationship between Obesity Factors and NK Cell Activity in White-Collar Females
2
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
효과적인 비만의 중재는 대상 인구에서 가장 관련성이 있는 인구통계학적 건강 관련 및 직무 관련 요인을 고려해야 한다. 가장 강력한 비만 관련 요인은 직업군 또는 연령 범주에서 다룰 수 있다. 이연구의 목적은 심리적인 직무 스트레스와 면역관련 인자의 혈액분석의 상관성에 대한 최신지견을 제공하는 것이다. 우리는 여성 근로자의 비만 관련 매개 변수 뿐만 아니라 자연살해세포활성(NKCA)을 평가하였다. 비만과 관련된 혈당(p＜0.05)은 연령에서유의한 차이를 보였다. 또한, 비만군과 non-비만군에서는 NK 세포의 활성에 큰 차이를 보였다(p＜0.05). 단계적 다중 회귀 분석에서 NKCA는 비만 관련 요인과 밀접한 상관성을 보였다. 향후에는면역인자들의 활성도가 증가하는 생물학적 변화를 연구해야 할 것이다.
Abstract
An effective strategy for obesity intervention should include demographic, health-related, and work-related factors that are most relevant to the target population. Factors most strongly associated with obesity may differ for groups of individuals across industries or age categories. The purpose of this study was to provide current knowledge about the possible association between psychosocial job stress and immune parameters in blood. We assessed obesity-related parameters as well as the natural killer cell activity (NKCA) in female workers. There was a significant difference in the obesity-related blood parameters, i.e. fasting blood sugar level, according to age (p＜0.05). Moreover, it showed a significant difference in NK cell activity between the obese and non-obese factor groups (p＜0.05). Pearson correlation analysis demonstrated that NKCA was closely correlated with obesity related factors. In the future, it would have to study the biological changes which increase the activity of the immune factors to the immunological response.
참고문헌 (25)
- Heraclides A, "Psychosocial stress at work doubles the risk of type 2 diabetes in middle-aged women : evidence from the Whitehall II study", Diabetes Care, 32, pp.2230~2510 (2009)
- Spruill TM, "Chronic psychosocial stress and hypertension", Curr Hypertens Rep, 12, pp.10~16 (2010)
- Aboa-Eboulé C, "Job strain and risk of acute recurrent coronary heart disease events", JAMA, 298, pp.1652~1660 (2007)
- Chandola T, "Chronic stress at work and the metabolic syndrome : prospective study", BMJ, 332, pp.521~525 (2006)
- McNeely E, "The consequences of job stress for nurses’ health. Time for a check-up", Nurs Outlook, 53, pp.291~299 (2005)
- Nakata A, "Job satisfaction is associated with elevated natural killer cell immunity among healthy white-collar employees", Brain Behav Immun, 24, pp.1268~1275 (2010)
- Lee KM, "A pilot study on the association between job stress and repeated measures of immunological biomarkers in female nurses", Int Arch Occup Environ Health, 83, pp.779~789 (2010)
- Eckel RH, "The metabolic syndrome", Lancet, 375, pp.181~183 (2010)
- "The Asia-Pacific perspective:Redefining obesity and its treatment 2000"[URL]
- Friedman EM, "Environmental stress mediates changes in neuroimmunological interactions", Toxicol Sci, 67, pp.4~10 (2002)
- Kawamura N1, "Suppression of cellular immunity in men with a past history of posttraumatic stress disorder", Am J Psychiatry, 158, pp.484~486 (2001)
- Zorrilla EP, "The relationship of depression and stressors to immunological assays : a meta-analytic review", Brain Behav Immun, 15, pp.199~226 (2001)
- Cooper MA, "Human natural killer cells : a unique innate immunoregulatory role for the CD56(bright)subset", Blood, 97, pp.3146~3151 (2001)
- Schroder K1, "Interferon-gamma : an overview of signals, mechanisms and functions", J Leukoc Biol, 75, pp.163~189 (2004)
- Morikawa Y, "A cross-sectional study on the relationship of job stress with natural killer cell activity and natural killer cell subsets among healthy nurses", J Occup Health, 47, pp.378~383 (2005)
- Lang J, "Psychosocial work stressors as antecedents of musculoskeletal problems : a systematic review and meta-analysis of stability-adjusted longitudinal studies", Soc Sci Med, 75, pp.1163~1174 (2012)
- Goodson NJ, "Cardiovascular risk factors associated with the metabolic syndrome are more prevalent in people reporting chronic pain : results from a cross-sectional general population study", Pain, 154, pp.1595~1602 (2013)
- Herr RM, "Three job stress models and their relationship with musculoskeletal pain in blue-collar and white-collar workers", J Psychosom Res, 79, pp.340~347 (2015)
- "Social ecological model 2013"[URL]
- Anastase Tchicaya, "Socioeconomic inequality and obesity prevalence trends in luxembourg, 1995–2007", BMC Research Notes, 5(1), pp.467~ (2012), Springer Nature[DOI]
- 신경아, "성인 남자의 비만 유형 중 운동 능력과 심혈관 질환 위험 인자 사이의 연관성", 대한임상검사과학회지, 45(3), pp.96~101 (2013), 대한임상검사과학회
- Schulte PA, "Work, obesity, and occupational safety and health", Am J Public Health, 97, pp.428~436 (2007)
- Luckhaupt SE, "Prevalence of obesity among U.S. workers and associations with occupational factors", Am J Prev Med, 46, pp.237~248 (2014)
- Jennifer L. Garza, "Demographic, health-related, and work-related factors associated with body mass index and body fat percentage among workers at six Connecticut manufacturing companies across different age groups: a cohort study", BMC Obesity, 2(1) (2015), Springer Nature[DOI]
- 현성희, "한국인의 혈청의 요산, 복부비만, 허리둘레 사이들의 관계", 대한임상검사과학회지, 44(2), pp.39~45 (2012), 대한임상검사과학회