본문 바로가기
KERD
논문KCI 등재

성인 남성에서 체질량지수로 분류한 비만 유형에 따른 혈청 감마글루타밀 전이효소와 혈청 요산농도의 차이 비교

Comparison of the Serum Gamma-Glutamyl Transferase and Serum Uric Acid Levels according to the Obesity Types Based upon on the Body Mass Index in Korean Men

신경아
대한임상검사과학회 (Korean Society for Clinical Laboratory Science)|2019.03|대한임상검사과학회지 (Korean Journal of Clinical Laboratory Science)|제51권 제1호|pp. 50-56|DOI 10.15324/kjcls.2019.51.1.50

0

조회

0

다운로드

1

인용

0

참고문헌

키워드

ObesityBody mass indexUric acidGamma-glutamyl transferase
주제분류기타자연과학

초록

본 연구는 성인 남성을 대상으로 체질량지수로 분류한 비만유형에 따른 혈청 GGT와 요산농도의 차이와 관련성을 확인하고자 하였다. 2017년 1월부터 2018년 8월까지 경기지역 종합병원의 건강검진센터를 내원하여 건강검진을 실시한 20세 이상 성인 남성 14,283명을 대상으로 하였다. 비만 기준은 아시아- 태평양지역 기준을 적용하였으며, 복부비만은 남성의 허리둘레 90 cm이상을 기준치로 정의하였다. 남성 대상자의 혈청 요산농도 상승은 7.0 mg/dL 이상, 혈청 GGT 상승은 56 IU/L 이상으로 정의하였다. 본 연구결과 혈청 GGT와 요산농도는 정상체중군보다 과체중과 비만군에서 높았으며, 비만군에서는 복부비만을 동반한 경우 혈청 GGT (53.26±49.67 IU/L vs 67.66± 60.16 IU/L) 및 요산농도(6.22±1.26 mg/dL vs 6.38±1.40 mg/dL)가 유의하게 높았다. 그러나 저체중군과는 차이가 없었다. 또한 과체중과 비만군은 정상체중군보다 혈청 GGT 상승과고요산혈증의 위험이 높게 나타났으나, 저체중은 혈청 GGT 상승과 고요산혈증에 영향을 미치지 않는 것으로 나타났다. 따라서 성인 남성의 과체중 및 비만을 평가하는데 혈청 GGT와 요산이 유용하다고 판단된다.

Abstract

This study examined the relationship between the serum GGT (gamma-glutamyl transferase) and uric acid level in obese male adults. A total of 14,283 adult males aged 20 years or more, who visited the health examination center of Gyeonggi Regional General Hospital from January 2017 to August 2018 and underwent a physical examination, were enrolled in this study. The obesity criteria were defined by the Asia-Pacific regional standards. Abdominal obesity was defined as a male waist circumference of more than 90 cm. An increase in the serum uric acid and serum CGT levels of the male subjects was defined as 7.0 mg/dL or more and 56 IU/L or more, respectively. The results showed that the serum GGT and uric acid levels were higher in the overweight and obese groups than in the normal weight group. In the obese group, the serum GGT and uric acid were significantly higher in the patients with abdominal obesity. On the other hand, there was no difference compared to the low body weight group. The overweight and obesity groups showed a higher risk of elevated serum GGT and hyperuricemia than the normal weight group, but a low body weight did not affect the serum GGT elevation and hyperuricemia. Overall, the serum GGT and uric acid levels are useful for evaluating overweight and obesity in adult males.

참고문헌 (40)

  1. Whitfield JB, "Gamma glutamyl transferase", Crit Rev Clin Lab Sci, 38, pp.263~355 (2001)
  2. Wu J, "Serum gamma-glutamyl transferase and uric acid levels are associated with impaired fasting glucose in adults from Inner Mongolia, China", BMC Public Health, 13, pp.294~ (2013)
  3. Thamer C, "Elevated serum GGT concentrations predict reduced insulin sensitivity and increased intrahepatic lipids", Horm Metab Res, 37, pp.246~251 (2005)
  4. Lee DH, "Gamma-glutamyl transferase and diabetes-a 4 year follow-up study", Diabetologia, 46, pp.359~364 (2003)
  5. Kerner A, "Association between elevated liver enzymes and C-reactive protein : possible hepatic contribution to systemic inflammation in the metabolic syndrome", Arterioscler Thromb Vasc Biol, 25, pp.193~197 (2005)
  6. Yunus YM, "Comparison of serum uric acid and gamma-glutamyl transpeptidase(GGT)level in obese individuals and non-obese individual", Int J Acad Res Bus Soc Sci, 7, pp.756~769 (2017)
  7. Feig DI, "Uric acid and the origins of hypertension", J Pediatr, 162, pp.896~902 (2013)
  8. Qin L, "Association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals", BMC Cardiovasc Disord, 14, pp.26~ (2014)
  9. Gonçalves JP, "Crosssectional and longitudinal associations between serum uric acid and metabolic syndrome", Endocrine, 41, pp.450~457 (2012)
  10. 신경아, "Clinical Usefulness of Serum Uric Acid and Resting Heart Rate in the Diagnosis of Metabolic Syndrome in Korean Adults", 대한의생명과학회지, 23(2), pp.118~127 (2017), 대한의생명과학회[DOI]
  11. Nakagawa T, "A causal role for uric acid in fructose-induced metabolic syndrome", Am J Physiol Renal Physiol, 290, pp.625~631 (2006)
  12. Sautin YY, "Adverse effects of the classic antioxidant uric acid in adipocytes : NADPH oxidase-mediated oxidative", nitrosative stress, 2007, pp.293, 584~596
  13. Cnop M, "The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments", Diabetes, 51, pp.1005~1015 (2002)
  14. Garg A, "Acquired and inherited lipodystrophies", N Engl J Med, 350, pp.1220~1234 (2004)
  15. "The Asia-Pacific perspective: redefining obesity and its treatment" (2000)[URL]
  16. 강덕희, "고요산혈증은 신장, 심혈관 및 대사 질환의 발생", 악화 인자인가?, 2011, pp.80(5), 524~528[DOI]
  17. Jalanko H, "Gamma-glutamyl transpeptidase in human amniotic fluid and in fetal tissues", Clin Chim Acta, 134, pp.337~346 (1983)
  18. Aksakal E, "The relation of serum gamma-glutamyl transferase levels with coronary lesion complexity and long-term outcome in patients with stable coronary artery disease", Atherosclerosis, 221, pp.596~601 (2012)
  19. Dogan A, "Gamma-glutamyltransferase in acute coronary syndrome patients without ST elevation and its association with stenotic lesion and cardiac events", Coron Artery Dis, 23, pp.39~44 (2012)
  20. Akpek M, "The prognostic value of serum gamma-glutamyl transferase activity on admission in patients with STEMI undergoing primary PCI", Angiology, 63, pp.579~585 (2012)
  21. Fan JG, "Fatty liver and the metabolic syndrome among Shanghai adults", J Gastroenterol Hepatol, 20, pp.1825~1832 (2005)
  22. 이규선, "성인 남성의 지방간과 비만, 간기능 및 고지혈증 지표와의 관련성", 한국산학기술학회논문지, 10(6), pp.1414~1423 (2009), 한국산학기술학회
  23. Marchesini G, "Nonalcoholic fatty liver disease : a feature of the metabolic syndrome", Diabetes, 50, pp.1844~1850 (2001)
  24. Yokoyama H, "Significant correlation between insulin resistance and serum gamma-glutamyl transpeptidase (gamma-GTP) activity in non-drinkers", Alcohol Clin Exp Res, 26(8 Suppl), pp.91~94 (2002)
  25. Ortega E, "Serum gamma-glutamyl transpeptidase is a determinant of insulin resistance independently of adiposity in Pima Indian children", J Clin Endocrinol Metab, 91, pp.1419~1422 (2006)
  26. Feig DI, "Uric acid and cardiovascular risk", N Engl J Med, 359, pp.1811~1821 (2008)
  27. Tsouli SG, "Elevated serum uric acid levels in metabolic syndrome: an active component or an innocent bystander?", Metabolism, 55, pp.1293~1301 (2006)
  28. Ya Z, "Association between serum gamma-glutamyl transferase and serum uric acid levels in Chinese females : a cross-sectional study", Endocr Res, 42, pp.296~301 (2017)
  29. Tsushima Y, "Uric acid secretion from adipose tissue and its increase in obesity", J Biol Chem, 288, pp.27138~27149 (2013)
  30. 홍수진, "전남, 광주지역의 건강검진센터에서의 고요산혈증의 빈도와 임상적 의의", 대한류마티스학회지, 19(3), pp.138~146 (2012), 대한류마티스학회[DOI]
  31. 김민수, "비만과 요석발생위험인자와의 관계", Investigative and Clinical Urology, 48(5), pp.505~511 (2007), 대한비뇨의학회
  32. Ali N, "Prevalence of hyperuricemia and the relationship between serum uric acid and obesity : A study on Bangladeshi adults", PLoS One, 13, pp.e0206850~ (2018)
  33. Dalton M, "Waist circumference, waist-hip ratio and body mass index and their correlation with cardiovascular disease risk factors in Australian adults", J Intern Med, 254, pp.555~563 (2003)
  34. Yano K, "Epidemiology of serum uric acid among 8000 Japanese-American men in Hawaii", J Chronic Dis, 30, pp.171~184 (1977)
  35. Chen JH, "Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality : a Chinese cohort study", Arthritis Rheum, 61, pp.225~232 (2009)
  36. Strasak A, "Serum uric acid and risk of cardiovascular mortality : a prospective long-term study of 83, 683 Austrian men", Clin Chem, 54, pp.273~284 (2008)
  37. Jin M, "Uric acid, hyperuricemia and vascular diseases", Front Biosci(Landmark Ed), 17, pp.656~669 (2012)
  38. Folsom AR, "Relation of body fatness and its distribution to cardiovascular risk factors in young blacks and whites", The role of insulin. Am J Epidemiol, 130, pp.911~924 (1989)
  39. Ye J, "Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob", ob and dietary obese mice, 2007, pp.293, 1118~1128
  40. Spiegelman BM, "Adipogenesis and obesity : rounding out the big picture", Cell, 87, pp.377~389 (1996)

관련 논문AI추천

한국 직장 남성에서 Gamma-glutamyltransferase와 대사증후군의 관련성박경희, 백유진, 변정수, 송홍지, 정형진, 조영규, 조정진대한가정의학회 · Korean Journal of Family Medicine2007 · 제28권 제1호비만하지 않은 성인 남성에서 대사증후군의 대리 표지자로서 감마 글루타밀 전이효소의 임상적 유용성 평가김은재, 신경아중소기업융합학회 · 융합정보논문지2020 · 제10권 제12호혈청 Gamma-Glutamyltransferase에 따른 복부비만과 제2형 다뇨병간의 관련성: Korean Genome and Epidemiology Study김동현, 김성희, 김양호, 김영욱, 노상철, 문재동, 신지연, 이덕희, 이용환, 임종한, 정진영, 주영수, 하은희, 홍영습, 황준현대한예방의학회 · 예방의학회지2009 · 제42권 제6호혈청 감마지티피 농도에 따른 대사증후군 발생 위험김민석, 김영주, 김윤진, 오신웅, 이상엽, 이정규, 정동욱대한가정의학회 · Korean Journal of Family Medicine2008 · 제29권 제11호한국인의 혈청의 요산, 복부비만, 허리둘레 사이들의 관계김인식, 안태호, 유세철, 윤진석, 이정화, 현성희대한임상검사과학회 · 대한임상검사과학회지2012 · 제44권 제2호성인에서 참고구간 내의 혈중 Gamma-glutamyltransferase 농도에 따른 대사증후군 및 제2형 당뇨병 발병률과의 관련성김달식, 배태원, 이재현, 이혜수, 조용곤, 최문석, 최삼임대한진단검사의학회 · Laboratory Medicine Online2013 · 제3권 제1호

이 간행물의 다른 논문 (14건)

한국, 일본, 미국 임상병리사 전문자격구본경pp. 1-14의료관련감염에서 감시 개선을 위한 평가박창은pp. 15-25동물 분자 진단 시장의 동향박성하, 박창은pp. 26-33Inhibitory Effects of Scopoletin in Collagen-induced Human Platelet AggregationDong-Ha Lee, Chang-Eun Park, 권혁우, 신정해pp. 34-41건강한 성인 남성의 대사증후군 위험 예측인자로서 혈청 요산/ 크레아티닌 비율김명수, 신경아pp. 42-49
원문 보기