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논문KCI 등재

비만하지 않은 성인 남성에서 대사증후군의 대리 표지자로서 감마 글루타밀 전이효소의 임상적 유용성 평가

Evaluation of Clinical Usefulness of Gamma Glutamyl Transferase as a Surrogate Marker for Metabolic Syndrome in Non Obese Adult Men

김은재|신경아
중소기업융합학회 (The Society of Convergence for Small and Medium Business)|2020.12|융합정보논문지 (Journal of Convergence for Information Technology)|제10권 제12호|pp. 146-155|DOI https://doi.org/10.22156/CS4SMB.2020.10.12.146

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참고문헌

키워드

임상적 유용성대사증후군Metabolic Syndrome간 효소감마 글루타밀 전이효소대리 표지자Liver EnzymeGamma Glutamyl TransferaseSurrogate MarkerClinical Usefulness

초록

본 연구는 대사증후군을 예측하는 대리 표지자로서 감마 글루타밀 전이효소(gamma glutamyl transferase, GGT)의 유용성을 평가하고자 하였다. 20세 이상의 비만하지 않은 남성 7,155명을 연구대상자로 하였다. 대사증후군 진단기준은 NCEP-ATP III (National Cholesterol Education Program - Third Adult Treatment Panel) 기준을 적용하였다. GGT에 따른 대사증후군 발병 위험도는 로지스틱 회귀분석을 적용하였으며, GGT의 대사증후군 위험 예측능력을 확인하기 위해 ROC (receiver operating characteristic) 곡선을 구하였다. 연령과 체질량지수와 무관하게 GGT 1사분위수보다 4사분위수에서 대사증후군 발병위험이 7.09배 높게 나타났다(p<0.001). 대사증후군 진단을 위한 GGT의 곡선아래면적(area under the curve)은 0.715였으며, GGT의 절단값(cut-off value)은 40.0 U/L, 민감도는 65.0%, 특이도 70.2%로 나타났다. 따라서 GGT는 대사증후군을 진단하기 위한 유용한 진단 지표로 판단된다.

Abstract

This study was to evaluate the usefulness of gamma glutamyl transferase (GGT) as a surrogate marker predicting metabolic syndrome. 7,155 non obese men over the age of 20 were studied as subjects. The criteria for diagnosing MetS were the National Cholesterol Education Program - Third Adult Treatment Panel (NCEP-ATP III). The risk of developing MetS according to GGT was conducted logistic regression analysis, and the ROC (receiver operating characteristic) curve was obtained to confirm GGT ability to predict the risk of MetS. Regardless of age and body mass index, MetS had a 7.09 times higher risk of onset in the fourth quartile than in the first quartile of GGT (p<0.001). The AUC (area under the curve) of GGT for the diagnosis of MetS was 0.715, and the cutoff value of GGT was 40.0 U/L, the sensitivity was 65.0%, and the specificity was 70.2%. Therefore, GGT is considered to be a useful diagnostic index for diagnosing MetS.

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혈청 감마지티피 농도에 따른 대사증후군 발생 위험김민석, 김영주, 김윤진, 오신웅, 이상엽, 이정규, 정동욱대한가정의학회 · Korean Journal of Family Medicine2008 · 제29권 제11호한국 직장 남성에서 Gamma-glutamyltransferase와 대사증후군의 관련성박경희, 백유진, 변정수, 송홍지, 정형진, 조영규, 조정진대한가정의학회 · Korean Journal of Family Medicine2007 · 제28권 제1호성인에서 참고구간 내의 혈중 Gamma-glutamyltransferase 농도에 따른 대사증후군 및 제2형 당뇨병 발병률과의 관련성김달식, 배태원, 이재현, 이혜수, 조용곤, 최문석, 최삼임대한진단검사의학회 · Laboratory Medicine Online2013 · 제3권 제1호The Association between Serum Gamma- Glutamyltransferase within Normal Levels and Metabolic Syndrome in Office Workers: A 4-Year Follow-up Study서병성대한가정의학회 · Korean Journal of Family Medicine2012 · 제33권 제1호성인 남성에서 체질량지수로 분류한 비만 유형에 따른 혈청 감마글루타밀 전이효소와 혈청 요산농도의 차이 비교신경아대한임상검사과학회 · 대한임상검사과학회지2019 · 제51권 제1호폐경 전과 후 여성에서 정상범위 내 혈청 GGT와 심혈관계질환 위험요인 및 대사증후군과의 연관성이건호한국모자보건학회 · 한국모자보건학회지2009 · 제13권 제2호

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