경기도 일개 종합병원에서 Pro-Brain Natriuretic Peptide와통상적 혈액검사 인자간의 상관성 조사
Study on the Relationship between Pro-Brain Natriuretic Peptide and Routine Blood Test Factors at a General Hospital in Gyeonggi-do
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초록
본 연구의 목적은 병원정보시스템을 활용하여 N-말단 프로- 뇌 나트륨 이뇨 펩타이드(N-terminal pro-brain natriuretic peptide, NT-proBNP)의 결과와 통상적인 혈액검사와의 상관성을 후향적으로 조사하는 것이다. NT-proBNP는 심부전의병태 생리학에 관여한다. 본 연구결과는 연령과 NT-proBNP 의 관계는 양의 상관관계(r=0.163)로 통계적으로 유의하였다(P＜0.01). NT-proBNP 농도는 총 단백질(r=−0.250)과 알부민(r=−0.270)은 음의 상관관계, 적혈구수와 혈색소 그리고 적혈구 용적률은 음의 상관관계로 나타난 결과로 나타났다(P＜ 0.01). NT-proBNP는 호중구와 양의 상관관계(r=0.227)와 림프구는 음의 상관관계(r=−0.236)로 통계적으로 유의한 결과가 나타났다(P＜0.01). NT-proBNP와 크레아티닌은 양의 상관관계로 나타났으며(r=0.594, P＜0.01), 다중회귀분석결과가장 영향을 미치는 인자로 관찰되었다(B=0.53, t=7.65, P＜ 0.01). NT-proBNP와 요산의 농도는 양의 상관관계로 유의한관계를 나타냈다(r=0.180, P＜0.05). 젖산탈수소효소가 NTproBNP에영향을 미치는 인자로 관찰되었다(B=0.20, t=3.28, P＜0.01). 이러한 설명력은 43%의 영향력을 나타내어 NTproBNP의정확한 검사와 관련인자들은 심장표지자로서 임상적 가치가 있는 것으로 사료된다.
Abstract
This study investigated retrospectively the correlation between the results of the N-terminal pro-brain natriuretic peptide (NT-proBNP) and a routine blood test using a hospital information system. The NT-proBNP is involved in the pathophysiology of heart failure. The results show that the relationship between age and NT-proBNP was significant (P＜0.01) with a positive correlation (r=0.163). The peptide concentration showed a negative correlation between the total protein (r= −0.250) and albumin (r=−0.270), and a negative correlation between the erythrocyte count and hemoglobin and hematocrit (P＜0.01). NT-proBNP had a positive correlation with neutrophils (r=0.227) and a negative correlation with lymphocytes (r=-0.236), showing significant results (P＜0.01). NT-proBNP and creatinine showed a positive correlation (r=0.594, P＜0.01), and it was the most influential factor according to multiple regression analysis (B=0.53, t=7.65). P＜0.01). The concentrations of NT-proBNP and uric acid showed a positive correlation (r=0.180, P＜0.05). Lactate dehydrogenase was observed as a factor affecting the NT-proBNP (B=0.20, t=3.28, P＜0.01). This explanatory power had an influence of 43%. Therefore, the accurate test and related factors of the NT-proBNP have significant clinical value.
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