본문 바로가기
KERD
논문KCI 등재

The Cytotoxic Action of New Ag-Porphyrin as a Potential Chemotherapeutic Agent

Aroutiounian Rouben|Babayan Nelli|Tovmasyan Artak|Gevorkyan Ani|Gasparyan Gennadi
한국환경생물학회 (Korean Society Of Environmental Biology)|2008.06|환경생물 (Korean Journal of Environmental Biology)|제26권 제2호|pp. 115-120

0

조회

0

다운로드

0

인용

0

참고문헌

초록

Abstract

- Earlier we have described new water-soluble Ag-and Zn-derivatives of tetrachloridemeso-tetra(4-N-oxiethylpyridyl) porphyrin(TOEtPyP) as potential anticancer drugs. In this workthe effect of one of these metal porphyrins, TOEtPyP Ag, on the cell population kinetics was stu-died in vitrousing morphological and biochemical techniques. The results suggested thatTOEtPyP Ag action consisted in the simultaneous suppression of the cell growth and activation ofthe cell death. About 40% of the cells were shown to die via apoptotic pathway. So, the porphyrinstudied may be attributed to inducers of both necrotic and apoptotic processes. The results ob-tained support our previous assertion that TOEtPyP Ag may be considered as a potential che-motherapeutic agent.

참고문헌 (30)

  1. Aderem A, "Mechanisms of phagocytosis in macrophages", Annu. Rev. Immunol, 17, pp.593~623 (1999)
  2. Al-Mutairi DA, "Photosensitizing action of isomeric Zn N-methylpyridyl porphyrins in human carcinoma cells", Free Radical Res, 40(5), pp.477~483 (2006)
  3. Berg K, "Porphyrin-related photosensitizers for cancer imaging and therapeutic applications", J. Microsc, 218(2), pp.133~147 (2005)
  4. Cohen GM, "Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation", Biochemical J, 286, pp.331~334 (1992)
  5. Darzynkiewicz Z., "Differential staining of DNA and RNA in intact cells and isolated cell nuclei with acridine orange", Methods Cell Biol, 33, pp.285~298 (1990)
  6. Ding L, "Oxidative cleavage of DNA mediated by hybrid metalloporphyrin- ellipticine molecules and functionalized metalloporphyrin precursors", Biochemistry, 29, pp.7868~7875 (1990)
  7. Ding L, "Anti-human immunodeficiency virus effects of cationic metalloporphyrin-ellipticine complexes", Biochem. Pharmacol, 44, pp.1675~1679 (1992)
  8. Dougherty TJ, "Photodynamic therapy", J. Natl. Cancer Inst, 90, pp.889~905 (1998)
  9. Foglieni C, "Fluorescent dyes for cell viability: an application on prefixed conditions", Histochem.Cell Biol, 115, pp.223~229 (2001)
  10. Gasparyan G, "In vitro testing of cyto- and genotoxicity of new porphyrin water-soluble metal derivatives", Int. J. Toxicol, 26, pp.479~502 (2007)
  11. Ghazaryan RK, "Patent of the Republic of Armenia No 1716 A2", ~ (2006)
  12. Ghazaryan RK, "Patent of the Republic of Armenia No 1715 A2", ~ (2006)
  13. Ghazaryan RK, "Patent of the Republic of Armenia No 1714 A2", ~ (2006)
  14. Hale AJ, "Apoptosis: molecular regulation of cell death", Eur. J. Biochem, 237, pp.884~ (1996)
  15. Hayhome BA, "Giemsa Staining to Monitor Cell Viability in Peridinium cinctum fa. Ovoplanum", Trans. Am. Microsc. Soc, 100, pp.410~414 (1981)
  16. In Vitro Diagnostic Medical Device, "Acridine orange zinc chloride double salt (C.I.46005) Certistain", ~ (2004)
  17. Jori G., "Photodynamic therapy of microbial infections: state of the art and perspectives", J. Environ. Pathol. Toxicol. Oncol, 25, pp.505~519 (2006)
  18. Kadish KM, "The Porphyrin Handbook" (2000), Academic Press
  19. Lambrechts SA, "Effect of albumin on the photodynamic inactivation of microorganisms by a cationic porphyrin", Photochem Photobiol, 79, pp.51~57 (2005)
  20. Luo Y, "Rapid Initiation of Apoptosis by Photodynamic Therapy", Photochem. Photobiol, 63(4), pp.528~534 (1996)
  21. Martirosyan A, "Metal-complex catalysis during the reduction of functional groups by borohydride in the synthesis of pyrrolidine derivatives", Chem. Heterocyclic Compounds, 42(2), pp.180~183 (2006)
  22. Ogura Sh, "Cellular localization and photodynamic effect of chlorin e6-monoclonal antibody conjugate", J. Porphyrins Phthalocyanines, 9, pp.138~141 (2005)
  23. Ohse T, "Cell death by reactive oxygen species generated from water-soluble cationic metalloporphyrins as superoxide dismutase mimics", J. Inorg. Biochem, 85(2), pp.201~208 (2001)
  24. MoonJeongShim, "Arsenic Trioxide Induces Apoptosis in Chronic Myelogenous Leukemia K562 Cells:Possible Involvement of p38 MAP Kinase", BMB reports, 35(4), pp.377~383 (2002), 한국생화학분자생물학회
  25. Stojiljkovic I, "Antimicrobial properties of porphyrins", Expert Opin Investig Drugs, 10, pp.309~320 (2001)
  26. Szurko A, "Photodynamic effects of two water soluble porphyrins evaluated on human malignant melanoma cells in vitro", Acta. Biochim. Pol, 50(4), pp.1165~1174 (2003)
  27. Tome JPC, "Synthesis and antibacterial activity of new poly-S-lysine-Porphyrin conjugates", J. Med. Chem, 47, pp.6649~6652 (2004)
  28. Vicente MGH, "Porphyrin-based sensitizers in the detection and treatment of cancer: recent progress", Curr. Med. Chem. Anticancer Agents, 1, pp.175~194 (2001)
  29. Vzorov AN, "Inactivation of human immunodeficiency virus type 1 by porphyrins", Antimicrob Agents Ch, 46, pp.3917~3925 (2002)
  30. Wyllie AH, "Cell death: the significance of apoptosis", Int. Rev. Cytol, 68, pp.251~306 (1980)

관련 논문AI추천

DNA damage induced by new pophyrins of different chemical structureAroutiounian Rouben, Ghazaryan Robert, Haroutiunian Samvel, Hovhannisyan Galina, Margaryan Kristina한국환경생물학회 · 환경생물2005 · 제23권 제4호Photodynamic Effects of Radachlorin on Cervical Cancer CellsChang-Hee Lee, Heung-Jae Chun, Hyun-Sun Jin, Jong-Ki Kim, Joon-Mo Lee, Sei-Jun Han, Su-Mi Bae, Sung-Eun Namkoong, Woong-Shick Ahn, Yong-Wook Kim대한암학회 · Cancer Research and Treatment2004 · 제36권 제6호Cytotoxic and Antimicrobial Activities of Bioactive MonoterpenophenolsHyungMinKim, HyunJaChun, HyunOkLee, InKioOh, JiHeeShin, JinALim, JongWoongAhn, SeungHwaBaek한의병리학회 · 동의생리병리학회지2002 · 제16권 제6호Synthesis, DNA Photocleavage and Singlet Oxygen Measurement of Cationic BisporphyrinsKai Wang, Qi Jin, Shuai-Hua Song, Xiulan Zhang대한화학회 · 대한화학회지2013 · 제57권 제2호Cytotoxic Activity of 13(E)-labd-13-ene-8α,15-diol on Human Epithelioid Carcinoma CellsIl Kwang Kim, Jin A Lim, Jung Sook Kwag, Nigel B. Perry, Seung Hwa Baek한의병리학회 · 동의생리병리학회지2005 · 제19권 제1호In vitro Cytotoxic Activity of Biflavonoid against P388 Murine Lymphocytic Leukemia Cells백승화, Jae Sook Lee한의병리학회 · 동의생리병리학회지2006 · 제20권 제5호

이 간행물의 다른 논문 (8건)

진해만에서 분리한 중심목 규조류 Skeletonema costatum (Grev.) Cleve의 성장에 미치는 광학적 특성양한섭, 오석진, 윤양호, 강인석pp. 57-65Inter Simple Sequence Repeats (ISSR) 표지자를 이용한 한국꿩의 유전적 다양성 및 아종간의 유연관계 분석윤성일pp. 66-75경상남도 함안군, 법수늪에서 엽록소 형광광도계(Phyto-PAM)에 의한 일차생산의 계절변동김미경pp. 76-86낙동강 하구에서 채집한 문절망둑 Acanthogobius flavimanus의 간장 약물대사효소계와 성호르몬 농도정지현, 한창희, 심원준, 전중균, 이지선pp. 87-93시화호에서 채집한 풀망둑 Acanthogobius hasta의 간장 약물대사효소계 및 항산화계의 반응이지선, 전중균, 심원준, 한창희, 정지현pp. 94-101
원문 보기