DNA damage induced by new pophyrins of different chemical structure
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Abstract
The new cationic meso substituted N quarternized 4 pyridylporphyrins and their metal derivatives were synthesized as novel chemotherapeutics. The level of DNA damage induced by porphyrins TOEt4PyP, TOBut4PyP, TOEt4PyPMn and TOBut4PyPMn and its dependence on the chemical structure of compounds were analyzed by the Comet assay. On the base of data obtained, the investigated porphyrins may be arranged by their genotoxic activity in the following order: TOEt4PyP¤TOEt4PyPMn¤TOBut4PyP¤TOBut4PyPMn. Thus, i) the genotoxicity of the Mn derivatives of TOEt4PyP and TOBut4PyP is higher than the original porphyrins and ii) the genotoxicity of TOEt4PyP and TOEt4PyPMn is increased after substitution of a butyl radical for ethyl one. The applied Comet assay permits to reveal the dependence of DNA damage induction on the chemical structure of porphyrins.
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