논문KCI 등재
In vitro Cytotoxic Activity of Biflavonoid against P388 Murine Lymphocytic Leukemia Cells
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Abstract
Biflavonoid (1) showed no antimicrobial activity at a concentration of 150 μg/disc. However, the crude extract of Quintinia acutifolia Kirk inhibited the growth of Bacillus subtilis and the dermatophytic fungus Trichophyton mentagrophytes. 2'',3''-Dihydroochanaflavone (1) showed some cytotoxicity with IC50 value of 3.1 μg/mL against P388 murine lymphocytic leukemia cells (positive control: mitomycin C IC50 0.06 μg/mL). The structure was determined by spectroscopic methods.
참고문헌 (6)
- Lee, J.S.,, "Antifungal activity of the crude extract from Quintinia acutifolia on the dermatophytic fungus", pp.508~510 (2005)
- Likhitwitayawuid, K.,, "Flavonoids from Ochna integerrima", pp.353~357 (2001)
- Schroeder, "Synthesis and biological effects of acyclic pyrimidine nucleoside analogues", pp.1078~1083 (1981)
- Baek, S.H.,, "Screening for biological activity of crude extract and bioactive fractions from Brochyglottis monroi", pp.826~828 (2003)
- Rao, K.V.,, "Two new biflavonoids from Ochna obtusata", pp.632~634 (1997)
- Rao, K.V.,, "Two new biflavonoids from Ochna obtusata", pp.632~634 (1997)
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