Effects of Lycium chinense Miller Fruit and its Constituent Betaine on Immunomodulation in Balb/c Mice
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BACKGROUND: The aim of this study is to investigate theeffects of Lycium chinense Miller fruit and itsrepresentative constituent betaine on reduction ofimmobility time and blood parameters in balb/c mice. METHODS AND RESULTS: We investigated theimmobility time and the changes in aspects of bloodbiochemical parameters by the administration of L. chinense Miller fruit and its representative constituentbetaine, after the forced swimming test. The immobilitytime was significantly reduced about 41.3% and 53.6%,respectively, in the animal of L. chinense Miller fruit and itsrepresentative constituent betaine-administrated group for7 days, in comparison with that of the control group. Thelevel of blood urea nitrogen was significantly decreased inL. chinense Miller fruit and its representative constituentbetaine-treated group compared with the control group (P <0.05), respectively. In addition, the interlukin-2 levels ofmice in L. chinense Miller fruit and betaine treated groupwas increased compared with the control group. CONCLUSION: These results indicate that L. chinenseMiller fruit and betaine might be helpful in the immunefunction improvement, enhance physical stamina, andfatigue recovery.
Abstract
BACKGROUND: The aim of this study is to investigate theeffects of Lycium chinense Miller fruit and itsrepresentative constituent betaine on reduction ofimmobility time and blood parameters in balb/c mice. METHODS AND RESULTS: We investigated theimmobility time and the changes in aspects of bloodbiochemical parameters by the administration of L. chinense Miller fruit and its representative constituentbetaine, after the forced swimming test. The immobilitytime was significantly reduced about 41.3% and 53.6%,respectively, in the animal of L. chinense Miller fruit and itsrepresentative constituent betaine-administrated group for7 days, in comparison with that of the control group. Thelevel of blood urea nitrogen was significantly decreased inL. chinense Miller fruit and its representative constituentbetaine-treated group compared with the control group (P <0.05), respectively. In addition, the interlukin-2 levels ofmice in L. chinense Miller fruit and betaine treated groupwas increased compared with the control group. CONCLUSION: These results indicate that L. chinenseMiller fruit and betaine might be helpful in the immunefunction improvement, enhance physical stamina, andfatigue recovery.
참고문헌 (20)
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