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Immune-boosting Effects of Chrysanthemum zawadskii Herbich var. latilobum Kitamura Extract on Cyclophosphamide-induced Immunosuppressed Sprague-Dawley Animal Model

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Background: Chrysanthemum zawadskii Herbich var. latilobum Kitamura extracts (CZE) is used to treat of various inflammatory and chronic diseases. Although commonly adminstered, no reports suggest its potential usage as an immune-booster. Methods and Results: In the cyclophosphamide (CP, 5 ㎎/㎏)-induced immunosuppression model, the immune-boosting effect of CZE (oral administration for 28 days with CP) was evalu- ated by investigating cell proliferation, activity of natural killer (NK) cells, cytotoxic T lympho- cytes, and production of CP-repressed cytokines [such as tumor necrosis factor-α, interferon-γ, interluekin (IL)-2, and IL-12] in isolated splenocytes. In Vitro, CZE treatment enhanced cell prolif- eration, activity of NK cells and cytotoxic T lymphocytes activity, and production of CP-repressed cytokines. In Vivo, CZE treatment promoted the production of white blood cells, lymphocytes, medium-sized cells, and granulocytes and proliferation of NK cells in CP-induced immunosup- pressed mice. Additionally, the CZE treatment restored the TNF-α and IL-12 reduced by CP to nor- mal levels and prevented spleen tissue damage. Conclusions: CZE could be an effective immune-booster and potentially be added to functional foods to enhance immunity.

Abstract

Background: Chrysanthemum zawadskii Herbich var. latilobum Kitamura extracts (CZE) is used to treat of various inflammatory and chronic diseases. Although commonly adminstered, no reports suggest its potential usage as an immune-booster. Methods and Results: In the cyclophosphamide (CP, 5 ㎎/㎏)-induced immunosuppression model, the immune-boosting effect of CZE (oral administration for 28 days with CP) was evalu- ated by investigating cell proliferation, activity of natural killer (NK) cells, cytotoxic T lympho- cytes, and production of CP-repressed cytokines [such as tumor necrosis factor-α, interferon-γ, interluekin (IL)-2, and IL-12] in isolated splenocytes. In Vitro, CZE treatment enhanced cell prolif- eration, activity of NK cells and cytotoxic T lymphocytes activity, and production of CP-repressed cytokines. In Vivo, CZE treatment promoted the production of white blood cells, lymphocytes, medium-sized cells, and granulocytes and proliferation of NK cells in CP-induced immunosup- pressed mice. Additionally, the CZE treatment restored the TNF-α and IL-12 reduced by CP to nor- mal levels and prevented spleen tissue damage. Conclusions: CZE could be an effective immune-booster and potentially be added to functional foods to enhance immunity.

참고문헌 (57)

  1. Adams DO, "The cell biology of macrophage activation", Annual Review of Immunology, 2, pp.283~318 (1984)
  2. Aggarwal BB, "Signalling pathways of the TNF superfamily : A double-edged sword", Nature Reviews Immunology, 3, pp.745~756 (2003)
  3. Blackburn MR, "Adenosine deaminase deficiency : Metabolic basis of immune deficiency and pulmonary inflammation", Advances in Immunology, 86, pp.1~41 (2005)
  4. Boyman O, "The role of interleukin-2 during homeostasis and activation of the immune system", Nature Reviews Immunology, 12, pp.180~190 (2012)
  5. 변명우, "마우스세포를 이용한 홍삼추출물과 생약복합추출물의 병용 처리에 따른 면역활성 효과", 한국식품영양과학회지, 44(2), pp.182~190 (2015), 한국식품영양과학회
  6. 장경미, "Volatiles of Chrysanthemum zawadskii var. latilobum K.", Preventive Nutrition and Food Science, 17(3), pp.234~238 (2012), 한국식품영양과학회[DOI]
  7. Chen X, "Green tea polysaccharide-conjugates protect human umbilical vein endothelial cells against impairments triggered by high glucose", International Journal of Biological Macromolecules, 49, pp.50~54 (2011)
  8. Chen X, "Thermal effects on the stability and antioxidant activity of an acid polysaccharide conjugate derived from green tea", Journal of Agricultural and Food Chemistry, 57, pp.5795~5798 (2009)
  9. Conniot J, "Cancer immunotherapy: Nanodelivery approaches for immune cell targeting and tracking", Frontiers in Chemistry, 2, pp.105~ (2014)
  10. Davis L, "Effect of Withania somnifera on cytokine production in normal and cyclophosphamide treated mice", Immunopharmacology and Immunotoxicology, 21, pp.695~703 (1999)
  11. Decker T, "The yin and yang of type I interferon activity in bacterial infection", Nature Reviews Immunology, 5, pp.675~687 (2005)
  12. Diwanay S, "Immunoprotection by botanical drugs in cancer chemotherapy", Journal of Ethnopharmacology, 90, pp.49~55 (2004)
  13. Elemans M, "Quantification of the relative importance of CTL, B cell, NK cell, and target cell limitation in the control of primary SIV- infection", PLOS Computational Biology, 7, pp.e1001103~ (2011)
  14. Fang Q, "Immunomodulatory activity on macrophage of a purified polysaccharide extracted from Laminaria japonica", Carbohydrate Polymers, 134, pp.66~73 (2015)
  15. Gu DR, "Inhibitory effect of Chrysanthemum zawadskii Herbich var. latilobum Kitamura extract on RANKL-induced osteoclast differentiation", Evidence-Based Complementary and Alternative Medicine, 2013, pp.509482~ (2013)
  16. Haddad PS, "Natural health products, modulation of immune function and prevention of chronic diseases", Evidence-Based Complementary and Alternative Medicine, 2, pp.513~520 (2005)
  17. ShinhaHan, "The Effect of Linarin on LPS-Induced Cytokine Production and Nitric Oxide Inhibition in Murine Macrophages Cell Line RAW264.7", Archives of Pharmacal Research, 25(3), pp.170~177 (2002), 대한약학회
  18. Hsu YL, "Acacetin inhibits the proliferation of Hep G2 by blocking cell cycle progression and inducing apoptosis", Biochemical Pharmacology, 67, pp.823~829 (2004)
  19. Hu TJ, "Protective effect of a Potentilla anserine polysaccharide on oxidative damages in mice", International Journal of Biological Macromolecules, 45, pp.279~283 (2009)
  20. Huang GC, "Immuno-enhancement effects of Huang Qi Liu Yi Tang in a murine model of cyclophosphamide-induced leucopenia", Journal of Ethnopharmacology, 109, pp.229~235 (2007)
  21. Hussain A, "Protective effects of Picrorhiza kurroa on cyclophosphamide-induced immunosuppression in mice", Pharmacognosy Research, 5, pp.30~35 (2013)
  22. Kim JG, "Bioconversion of black rice and blueberry regulate immunity system through regulation of MAPKs, NF-kB in RAW264. 7 macrophage cells", Food and Agricultural Immunology, 32, pp.471~481 (2021)
  23. Klimp AH, "A potential role of macrophage activation in the treatment of cancer", Critical Reviews in Oncology, 2002, pp.44, 143~161
  24. Kos FJ, "Immune regulation : A critical link between NK cells and CTLs", Immunology Today, 17, pp.174~176 (1996)
  25. 이현정, "흰 쥐의 턱관절 염증성 통증모델에서 홍삼 및 흑삼추출물의 효과", 치위생과학회지, 17(1), pp.65~72 (2017), 한국치위생과학회[DOI]
  26. Lee HY, "Immunostimulatory effect of Zanthoxylum schinifolium-based complex oil prepared by supercritical fluid extraction in splenocytes and cyclophosphamide-induced immunosuppressed rats", Evidence-Based Complementary and Alternative Medicine, 2018, pp.8107326~ (2018)
  27. Lee J, "The immunostimulating activity of quercetin 3-O-xyloside in murine macrophages via activation of the ASK1", MAPK, International Immunopharmacology, pp.2016, 31[DOI]
  28. 이미라, "백삼과 홍삼추출물의 학습수행과 Acetylcholinesterase 억제에 미치는 효과", Journal of Ginseng Research, 32(4), pp.341~346 (2008), 고려인삼학회
  29. Li WJ, "Ganoderma atrum polysaccharide ameliorates ROS generation and apoptosis in spleen and thymus of immunosuppressed mice", Food and Chemical Toxicology, 99, pp.199~208 (2017)
  30. Lin PL, "Tumor necrosis factor and tuberculosis", Journal of Investigative Dermatology Symposium Proceedings, 12, pp.22~25 (2007)
  31. Mcaleer JP, "Understanding how lipopolysaccharide impacts CD4 T-cell immunity", Critical Reviews™ in Immunology, 28, pp.281~299 (2008)
  32. Medzhitov R, "Innate immunity : Impact on the adaptive immune response", Current Opinion in Immunology, 9, pp.4~9 (1997)
  33. Motta M, "Immune system development in infants born to mothers with autoimmune disease, exposed in utero to immunosuppressive agents", American Journal of Perinatology, 24, pp.441~447 (2007)
  34. Noh EM, "Immuno-enhancement effects of platycodon grandiflorum extracts in splenocytes and a cyclophosphamide-induced immunosuppressed rat model", BMC Complementary Medicine and Therapies, 19, pp.322~ (2015)
  35. Pass GJ, "Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide : Studies with the hepatic cytochrome p450 reductase null mouse", Cancer Research, 65, pp.4211~4217 (2005)
  36. Pierce S, "Targeting natural killer cells for improved immunity and control of the adaptive immune response", Frontiers in Cellular and Infection Microbiology, 10, pp.231~ (2020)
  37. Raj S, "Immunomodulatory activity of methanolic extract of Amorphophallus commutatus var. wayanadensis under normal and cyclophosphamide induced immunosuppressive conditions in mice models", Food and Chemical Toxicology, 81, pp.151~159 (2015)
  38. Sarangi I, "Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans", International Immunopharmacology, 6, pp.1287~1297 (2006)
  39. 서지연, "Protection by Chrysanthemum zawadskii extract from liver damage of mice caused by carbon tetrachloride is maybe mediated by modulation of QR activity", Nutrition Research and Practice, 4(2), pp.93~98 (2010), 한국영양학회
  40. Shalit I, "Immunomodulatory effects of moxifloxacin in comparison to ciprofloxacin and G-CSF in a murine model of cyclophosphamide-induced leukopenia", European Journal of Haematology, 66, pp.287~296 (2001)
  41. 심선엽, "Isolation and Identification of Flavonoids from Gujeolcho (Chrysanthemum zawadskii var. latilobum) as Inhibitor of Histamine Release", Food Science and Biotechnology, 21(2), pp.613~617 (2012), 한국식품과학회[DOI]
  42. Shim, Sun-Yup, "6-Methoxyluteolin from Chrysanthemum zawadskii var. latilobum Suppresses Histamine Release and Calcium Influx via Down-Regulation of FcεRI α Chain Expression", Journal of Microbiology and Biotechnology, 22(5), pp.622~627 (2012), 한국미생물·생명공학회[DOI]
  43. Shin JS, "Immunostimulatory effects of cordycepin-enriched WIB-801CE from Cordyceps militaris in splenocytes and cyclophosphamide-induced immunosuppressed mice", Phytotherapy Research, 32, pp.132~139 (2018)
  44. Singh RP, "Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells : Structure-activity relationship with linarin and linarin acetate", Carcinogenesis, 26, pp.845~854 (2005)
  45. Song X, "Anti-tumor and immunomodulatory activities induced by an alkali-extracted polysaccharide BCAP-1 from Bupleurum chinense via NF-κB signaling pathway", International Journal of Biological Macromolecules, 95, pp.357~362 (2017)
  46. Spiering MJ, "Primer on the immune system", Alcohol Research, 37, pp.171~175 (2015)
  47. Springer TA, "Adhesion receptors of the immune system", Nature, 346, pp.425~434 (1990)
  48. Tough DF, "T cell stimulation in vivo by lipopolysaccharide(LPS)", Journal of Experimental Medicine, 185, pp.2089~2094 (1997)
  49. Ulmer AJ, "Induction of proliferation and cytokine production in human T lymphocytes by lipopolysaccharide(LPS)", Toxicology, 152, pp.37~45 (2000)
  50. Wang H, "Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry", Carbohydrate Polymers, 131, pp.288~296 (2015)
  51. Wang H, "A polysaccharide from Strongylocentrotus nudus eggs protects against myelosuppression and immunosuppression in cyclophosphamide-treated mice", International Immunopharmacology, 11, pp.1946~1953 (2011)
  52. Wang S, "Prevention of Cyclophosphamide-induced immunosuppression in mice with the antimicrobial peptide sublancin", Journal of Immunology research, 2018, pp.4353580~ (2018)
  53. Wynn TA, "Macrophage biology in development, homeostasis and disease", Nature, 496, pp.445~455 (2013)
  54. Yan H, "Prevention of cyclophosphamide-induced immunosuppression in mice with traditional Chinese medicine Xuanfei Baidu decoction", Frontiers in Pharmacology, 12, pp.730567~ (2021)
  55. Yu Q, "Chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced mice", International Journal of Biological Macromolecules, 64, pp.395~401 (2014)
  56. Zeng G, "Immunopontentiating activities of the purified polysaccharide from evening primrose in H22 tumor-bearing mice", International Journal of Biological Macromolecules, 52, pp.280~285 (2013)
  57. Zhou Y, "Immunomodulatory Effect of Tremella Polysaccharides against Cyclophosphamide-Induced Immunosuppression in Mice", Molecules, 23, pp.239~ (2018)

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