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DNA Binding Studies and Cytotoxicity of the Novel 1,10-phenanthroline Palladium(II) Complexes of Dithiocarbamate Derivatives

Adeleh Divsalar|Hassan Mansouri-Torshizi|Maryam Saeidifar|Zahra Yekke Ghasemi|Mahmood Khastan|Ali Akbar Saboury
대한화학회|2011.02|대한화학회지 (Journal of the Korean Chemical Society)|제55권 제1호|pp. 70-80

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참고문헌

키워드

cytotoxicity세포독성DNA bindingPd(II) complexpiperidinedithiocarbamatemorpholinedithiocarbamateDNA 결합팔라디움(II) 착물피페리딘디티오카르바메이트모르폴린디티오카르바메이트
주제분류화학

초록

Two new palladium (II) complexes, [Pd (phen)(pip-dtc)]NO_3 and [Pd(phen)(mor-dtc)]NO_3, (where phen is 1,10-Phenantroline, pip-dtc is piperidinedithiocarbamate anion and mor-dtc is morpholinedithiocarbamate anion) have been synthesized and characterized by elemental analysis, spectroscopic studies (FT-IR, ^1 H NMR, UV-Vis) and conductance measurement. In these complexes, the dithiocarbamate ligands coordinate with Pd (II) center as bidentate with two sulfur atoms. These two complexes have been tested against chronic myelogenous leukemia cell line, K562. They show IC_(50) values less than cisplatin and thus the mode of binding of the complexes to calf thymus DNA (CT-DNA) were investigated by ultraviolet difference and fluorescence spectroscopy. They can denature DNA, exhibit cooperative binding and intercalate into DNA. Several binding and thermodynamic parameters are also described.

Abstract

Two new palladium (II) complexes, [Pd (phen)(pip-dtc)]NO_3 and [Pd(phen)(mor-dtc)]NO_3, (where phen is 1,10-Phenantroline, pip-dtc is piperidinedithiocarbamate anion and mor-dtc is morpholinedithiocarbamate anion) have been synthesized and characterized by elemental analysis, spectroscopic studies (FT-IR, ^1 H NMR, UV-Vis) and conductance measurement. In these complexes, the dithiocarbamate ligands coordinate with Pd (II) center as bidentate with two sulfur atoms. These two complexes have been tested against chronic myelogenous leukemia cell line, K562. They show IC_(50) values less than cisplatin and thus the mode of binding of the complexes to calf thymus DNA (CT-DNA) were investigated by ultraviolet difference and fluorescence spectroscopy. They can denature DNA, exhibit cooperative binding and intercalate into DNA. Several binding and thermodynamic parameters are also described.

참고문헌 (56)

  1. Chen, X., , Inorg. Chim. Acta, 360, pp.2851~ (2007)
  2. Wong, E., , Chem. Rev, 99, pp.2451~ (1999)
  3. Guo, Z., , Angew. Chem., Int. Ed, 38, pp.1512~ (1999)
  4. Pizarro, A. M., , Biochim, 91, pp.1198~ (2009)
  5. Liu, M., , Spectrochim. Acta A, 70, pp.1114~ (2008)
  6. Kumar, C. V., , J. Am. Chem. Soc, 115, pp.22~ (1993)
  7. He, X. Q., , Spectrochim. Acta A, 68, pp.184~ (2007)
  8. Gerasimchuk, N., , Inorg. Chem, 46, pp.7268~ (2007)
  9. Kranz, F., , Cancer J, 11, pp.176~ (1998)
  10. Faraglia, G., , Inorg. Biochem, 83, pp.31~ (2001)
  11. Dorr, R.T., "Platinum and other Metal Coordination Compounds in Cancer Chemotherapy", pp.131~ (1996), Plenum
  12. Zunino, F., , Chem. Biol. Interact, 70, pp.89~ (1989)
  13. Burgeson, I. E., , Inorg. Chem, 30, pp.4299~ (1991)
  14. Appleton, T. G., , Inorg. Chem, 28, pp.2030~ (1989)
  15. Palocsay, F. A., , Inorg. Chem, 8, pp.524~ (1969)
  16. Mansouri-Torshizi, H., , J. Biomol. Struct. dyn, 26, pp.575~ (2009)
  17. Manav, N., , Spectrochim. Acta A, 60, pp.3087~ (2004)
  18. Bi, S., , Spectrochim. Acta A, 69, pp.123~ (2008)
  19. Marmur, J., , J. Mol. Biol, 3, pp.208~ (1961)
  20. Senthil Kumar, R., , Polyhedron, 25, pp.3113~ (2006)
  21. Mital, R., , Inorg. Chim. Acta, 166, pp.135~ (1989)
  22. Ronconi, L., , Inorg. Chem, 44, pp.1867~ (2005)
  23. Manohar, A., , Inorg. Chim. Acta, 314, pp.177~ (2001)
  24. Kumar, L., , J. Inorg. Biochem, 23, pp.1~ (1985)
  25. Geary, W. J., , Coord. Chem. Rev, 7, pp.81~ (1971)
  26. Gao, E., , Eur. J. Med. Chem, 45, pp.311~ (2010)
  27. Matesanz, A. I., , J. Inorg. Biochem, 76, pp.29~ (1999)
  28. Gao, E., , J. Inorg. Biochem, 102, pp.1958~ (2008)
  29. Divsalar, A., , J. Biomol. Struct. Dyn, 25, pp.173~ (2007)
  30. Mansouri-Torshizi, H., , Spectrochim. Acta A, 77, pp.312~ (2010)
  31. H. Mansouri-Torshizi, "Interaction Studies of a Novel, Water-Soluble and Anti-Cancer Palladim(II) Complex with Calf Thymus DNA", Bulletin of the Korean Chemical Society, 31(2), pp.435~441 (2010), 대한화학회
  32. Greene, R. F., , J. Biol. Chem, 249, pp.5388~ (1974)
  33. Saboury, A. A., , Biochem. Edu, 22, pp.48~ (1994)
  34. Gao, E., , Eur. J. Med. Chem, 45, pp.311~ (2010)
  35. Wang,Q., , Eur. J. Med. Chem, 44, pp.2425~ (2009)
  36. Xu, Z. H., , J. Photochem. Photobiol A. Chem, 196, pp.77~ (2008)
  37. Peres-Flores, L., , Spectrochim. Acta A, 69, pp.1089~ (2008)
  38. Xi, P. X., , Spectrochim. Acta A, 71, pp.523~ (2008)
  39. Mansouri-Torshizi, H., , Bioorg. Med. Chem, 16, pp.9616~ (2008)
  40. I-Moghaddam, M., , J. Iran. Chem. Soc, 6, pp.552~ (2009)
  41. King, A. M. Q., , Biochem. J, 114, pp.679~ (1969)
  42. Bathaie, S. Z., , DNA Cell Biol, 26, pp.533~ (2007)
  43. Barrow, G. M., "In Physical Chemistry, chap. 7, 5th ed", pp.201~ (1988), MC Graw-Hill
  44. Scatchard, G., , Ann. N. Y. Acad. Sci, 51, pp.660~ (1949)
  45. Hill, A. V., , J. physil. (Lond.), 40, pp.4~ (1910)
  46. Penga, B., , Spectrochim. Acta A, 74, pp.896~ (2009)
  47. Chao, H., , J. Inorg. Biochem, 92, pp.165~ (2002)
  48. Wang, Q., , Eur. J. Med. Chem, 14, pp.2425~ (2009)
  49. Peng, B., , Spectrochim. Acta A, 74, pp.896~ (2009)
  50. Mansouri-Torshizi, H., , Acta Biochim. Biophys. Sin, 35, pp.886~ (2003)
  51. Zhang, G., , J. Mol. Struct, 923, pp.114~ (2009)
  52. Wu, X., , Spectrochim. Acta A, 65, pp.543~ (2006)
  53. Satyanarayana, S., , Biochemistry, 31, pp.9319~ (1992)
  54. Zeng, Y. B., , J. Inorg. Biochem, 97, pp.258~ (2008)
  55. Kumar, C. V., , J. Am. Chem. Soc, 107, pp.5518~ (1985)
  56. Wu, F., "F.J.Lumines 2009", J. Lumines, 129, pp.1286~ (2009)

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