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우울증 환자와 정상인의 전두엽 알파파 비대칭 현상 연구

Depression and Baseline Prefrontal EEG Alpha Wave Asymmetry

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참고문헌

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주제분류심리과학

초록

본 연구는 우울증 환자들에게서 나타나는 전두엽 알파파 비대칭 현상을 확인하기 위해 수행되었다. 연구 대상자는 총 88명으로, 현재 우울증 환자와 과거 우울증 환자를 포괄하는 우울증 환자집단 59명과 정신병력이 없는 정상집단 29명을 대상으로 정량적 뇌전위(QEEG)를 측정하였다. 연구결과, 정상집단이 우울집단에 비해 상대적으로 높은 좌반구 전두엽 활동성을 나타냈으며, 우울집단은 상대적으로 높은 우반구 전두엽 활동성을 나타냈다. 또한 모든 비대칭 지수에서 현재 우울집단과 과거 우울집단, 주요우울집단과 다른 우울집단 간 유의한 차이가 나타나지 않아, 우울집단의 좌반구 열세 현상은 삽화나 세부진단에 따른 차이에 유의한 영향을 받지 않음이 확인되었다. 우울증상의 변화 정도나 경중에 관계없이 우울증 환자가 정상인에 비해 좌반구의 상대적 활동이 약한 전두엽 비대칭 현상을 나타내며, 우울증상의 회복여부와 관련 없이 비대칭 지수가 지속적으로 유지된다는 본 연구의 결과는 뇌파 비대칭이 개인의 우울증 취약성을 의미하는 하나의 안정된 특성이 될 수 있음을 시사한다.

Abstract

The aim of this study was to examine the relationship between alpha asymmetry in prefrontal cortex (PFC) electroencephalography (EEG) and depression. We compared the resting baseline PFC alpha activity of a depressed patient group (N = 59) and that of a healthy control group (N = 29). Using one way ANOVAs, significant group effects were found in all asymmetry indexes. The depression group showed relatively low activity in the left PFC. There were no significant effects of episode state or diagnostic subtype. There were no differences in asymmetry indexes between current depressed patients and previously depressed patients. We could not find any differences in asymmetry scores between the major depressive disorder group and the other depression group. These results indicate that PFC EEG asymmetry is a trait marker for depression.

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