주요우울증에서 우울과 불안 증상의 심각도에 따른 뇌파 A1, A2, Percent 비대칭 지표들의 특성 연구
EEG A1, A2, and Percent Asymmetry Indices in Major Depressive Disorder; The Importance of Symptom Severity of Depression and Anxiety
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본 연구에서는 대표적인 뇌파 비대칭 지표인 A1, A2, PCT 비대칭 지표들을 이용하여 최근 4주 이내에 약물 복용이 없는 주요우울증 환자 11명과 정상군 11명을 대상으로 우울 및 불안 증상의 심각도에 따라서 뇌파의 비대칭 패턴이 어떠한 특성을 나타내는지를 조사하였다. 연구결과 첫째로 우울군과 대조군 간에는 측두엽 부위에서 A1, A2, PCT 비대칭 지표값에서 유의한 차이가 나타났다. 둘째로 특성 불안(STAI-T) 점수가 전두엽(F3와 F4)과 측두엽 (T7와 T8) 부위에서 A1, A2, PCT 비대칭 지표들과 유의한 부적 상관관계를 나타냈다. 우울군과 대조군 사이의 차이 및 특성 불안(STAI-T)과 상관관계에서 PCT 비대칭 지표는 A1이나 A2 비대칭 지표에 비하여 확고한 차이를 나타냈다. 이 연구를 통해서 이들 세 가지 뇌파 비대칭 지표들이 주요우울증에서 유용한 지표로 사용될 수 있음을 확인하였다. 또한 특성 불안이 이들 비대칭 지표에 상당한 영향을 미친다는 결과를 얻었다.
Abstract
Objectives：In this study we investigated characteristics of asymmetry pattern of EEG in patients with major depressive disorder according to the severity of depression and anxiety symptoms, employing A1, A2, and Percent (PCT) asymmetry indices. Methods：Subjects involved in this study were 11 healthy controls and 11 patients with major depressive disorder who have taken no medicines for four weeks just before the study. These subjects were selected so that the two groups can have no difference in gender and age. Beck Depression Inventory (BDI), 17-item Hamilton Depression Rating Scale (HDRS), Zung’s Self-Rating Depression Scale (SDS) and Spielberger’s State-Trait Anxiety Inventory (STAI) were used to evaluate depression and anxiety symptoms, respectively. Resting EEG was recorded from F3, F4, C3, C4, T7, T8, O1 and O2 electrode sites. Results：The temporal region showed a difference in A1, A2, and PCT asymmetry indices between the depression group and the control group. Frontal (F3, F4) and temporal (T7, T8) regions showed correlation between STAI-T score and A1, A2, and PCT asymmetry indices. Conclusion：The results of this study showed that EEG A1, A2, and PCT asymmetry indices can be used as useful indices for depression. Also, it was found that trait anxiety had influence on A1, A2, and PCT asymmetry indices. (J Korean Neuropsychiatr Assoc 2007;46(2):179-184)
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