Coated cysteamine, a potential feed additive for ruminants — An updated review
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For sustainable development, better performance, and less gas pollution during rumen fermentation, there is a need to find a green and safe feed additive for ruminants. Cysteamine (CS) is a biological compound naturally produced in mammalian cells. It is widely used as a growth promoter in ruminants because of its ability to control hormone secretions. It mainly controls the circulating concentration of somatostatin and enhances growth hormone production, leading to improved growth performance. CS modulates the rumen fermentation process in a way beneficial for the animals and environment, leading to less methane production and nutrients loss. Another beneficial effect of using CS is that it improves the availability of nutrients to the animals and enhances their absorption. CS also works as an antioxidant and protects the cells from oxidative damage. In addition, CS has no adverse effects on bacterial and fungal alpha diversity in ruminants. Dietary supplementation of CS enhances the population of beneficial microorganisms. Still, no data is available on the use of CS on reproductive performance in ruminants, so there is a need to evaluate the effects of using CS in breeding animals for an extended period. In this review, the action mode of CS was updated according to recently published data to highlight the beneficial effects of using CS in ruminants.
Abstract
For sustainable development, better performance, and less gas pollution during rumen fermentation, there is a need to find a green and safe feed additive for ruminants. Cysteamine (CS) is a biological compound naturally produced in mammalian cells. It is widely used as a growth promoter in ruminants because of its ability to control hormone secretions. It mainly controls the circulating concentration of somatostatin and enhances growth hormone production, leading to improved growth performance. CS modulates the rumen fermentation process in a way beneficial for the animals and environment, leading to less methane production and nutrients loss. Another beneficial effect of using CS is that it improves the availability of nutrients to the animals and enhances their absorption. CS also works as an antioxidant and protects the cells from oxidative damage. In addition, CS has no adverse effects on bacterial and fungal alpha diversity in ruminants. Dietary supplementation of CS enhances the population of beneficial microorganisms. Still, no data is available on the use of CS on reproductive performance in ruminants, so there is a need to evaluate the effects of using CS in breeding animals for an extended period. In this review, the action mode of CS was updated according to recently published data to highlight the beneficial effects of using CS in ruminants
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- Velazco JI, "Methane emissions and feeding behaviour of feedlot cattle supplemented with nitrate or urea", Anim Prod Sci, 54, pp.1737~1740 (2014)[DOI]
- Hristov AN, "An inhibitor persistently decreased enteric methane emission from dairy cows with no negative effect on milk production", Proc Natl Acad Sci USA, 112, pp.10663~10668 (2015)[DOI]
- Argente J, "The growth hormone axis : control and effects", Horm Res, 45, pp.9~11 (1996)[DOI]
- Wathes DC, "Regulation of insulin-like growth factor-I and progesterone synthesis by insulin and growth hormone in the ovine ovary", Biol Reprod, 53, pp.882~889 (1995)[DOI]
- Galbraith H, "Hormones in international meat production : biological, sociological and consumer issues", Nutr Res Rev, 15, pp.293~314 (2002)[DOI]
- McElwain KV, "Effect of cysteamine hydrochloride on secretion of growth hormone in male swine", Life Sci, 64, pp.2233~2238 (1999)[DOI]
- Sagar SM, "Depletion of somatostatin-like immunoreactivity in the rat central nervous system by cysteamine", J Neurosci, 2, pp.225~231 (1982)[DOI]
- Vasin MV, "Comments to the mechanism of protective and pharmacological action of radioprotectors from the family of aminothiols", J Radioprot Res, 2, pp.15~36 (2014)[DOI]
- McLeod KR, "Cysteamine-induced depletion of somatostatin in sheep : time course of depletion and changes in plasma metabolites, insulin, and growth hormone", J Anim Sci, 73, pp.77~87 (1995)[DOI]
- Yang JD, "Effects of cysteamine on performance, nutrient digestibility and serum biochemical indices of beef cattle", Chin J Anim Nutr, 18, pp.261~266 (2006)
- Bin J, "Effects of cysteamine on weight gain and wool gain in female lambs", Heilongjiang J Anim Sci Vet Med, 11 (2003)
- Jia-dong Y, "Effects of cysteamine on performance, nutrient digestibility and serum biochemical indices in beef cattle", Chin Anim Sci, 4 (2006)
- Liu N, "Effect of cysteamine hydrochloride supplementation on the growth performance, enterotoxic status, and glutathione turnover of broilers fed aflatoxin B1 contaminated diets", Poult Sci, 97, pp.3594~3600 (2018)[DOI]
- Barnett MC, "Cysteamine hydrochloride increases bodyweight and wool fibre length, improves feed conversion ratio and reduces methane yield in sheep", Anim Prod Sci, 54, pp.1288~1293 (2014)[DOI]
- Besouw M, "Cysteamine : an old drug with new potential", Drug Discov Today, 18, pp.785~792 (2013)[DOI]
- Desai S, "Topical stabilized cysteamine as a new treatment for hyperpigmentation disorders : melasma, post-inflammatory hyperpigmentation, and lentigines", J Drugs Dermatol, 20, pp.1276~1279 (2021)[DOI]
- Eldjam L, "On the mechanism of chemical protection against ionizing radiation. The interaction of cysteamine and cystamine with proteins", 4th international conference on progress in radiobiology, pp.249~257 (1956)
- "Physiology, somatostatin" (2022)[URL]
- Peters GE, "Distribution and metabolism of exogenous somatostatin in the rat", Regul Pept, 3, pp.361~369 (1982)[DOI]
- Montoro JB, "Stability of somatostatin in total parenteral nutrition", Pharm Weekbl, 12, pp.240~242 (1990)[DOI]
- Bousquet M, "Cystamine metabolism and brain transport properties : clinical implications for neurodegenerative diseases", J Neurochem, 114, pp.1651~1658 (2010)[DOI]
- Liu G, "Effects of dietary supplementation with cysteamine on growth hormone receptor and insulin-like growth factor system in finishing pigs", J Agric Food Chem, 56, pp.5422~5427 (2008)[DOI]
- Szabo S, "New molecular mechanisms of duodenal ulceration", Ann NY Acad Sci, 1113, pp.238~255 (2007)[DOI]
- Haenen GR, "Effect of thiols on lipid peroxidation in rat liver microsomes", Chem Biol Interact, 71, pp.201~212 (1989)[DOI]
- de Matos DG, "Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro", Mol Reprod Dev, 42, pp.432~436 (1995)[DOI]
- Kessler A, "Antioxidant effect of cysteamine in brain cortex of young rats", Neurochem Res, 33, pp.737~744 (2008)[DOI]
- Winterbourn CC, "Thiol chemistry and specificity in redox signaling", Free Radic Biol Med, 45, pp.549~561 (2008)[DOI]
- Wu G, "Glutathione metabolism and its implications for health", J Nutr, 134, pp.489~492 (2004)[DOI]
- Cognié Y, "Current status of embryo technologies in sheep and goat", Theriogenology, 59, pp.171~188 (2003)[DOI]
- Kobayashi M, "Cysteamine or beta-mercaptoethanol added to a defined maturation medium improves blastocyst formation of porcine oocytes after intracytoplasmic sperm injection", Theriogenology, 65, pp.1191~1199 (2006)[DOI]
- Prescott LF, "Cysteamine or N-acetylcysteine for paracetamol poisoning?", Br Med J, 1, pp.856~857 (1978)
- Hu R, "Effects of GHRP-2 and cysteamine administration on growth performance, somatotropic axis hormone and muscle protein deposition in yaks(Bos grunniens)with growth retardation", PloS one, 11, pp.e0149461~ (2016)[DOI]
- Sun YK, "The effect of cysteamine hydrochloride and nitrate supplementation on in-vitro and in-vivo methane production an productivity of cattle", Anim Feed Sci Technol, 232, pp.49~56 (2017)[DOI]
- Wu QC, "Dietary cysteamine supplementation remarkably increased feed efficiency and shifted rumen fermentation toward glucogenic propionate production via enrichment of Prevotella in feedlot lambs", Microorganisms, 10, pp.1105~ (2022)[DOI]
- Yanling W, "Effects of cysteamine on the milk yield and plasma levels of somatostatin and growth hormone in dairy cow", Chin J Anim Sci, 6, pp.14~15 (1999)
- Li C, "Effects of cysteamine preparation on dairy performance", J Shanghai Jiaotong University, 4 (2001)
- Lunzhi X, "Effects of cysteamine on performance and serum hormone levels in lactating dairy cows", China Herbivores, 24, pp.6~8 (2004)
- Wang C, "Effect of cysteamine hydrochloride supplementation on the milk performance of dairy cow", Livest Sci, 178, pp.94~99 (2015)[DOI]
- Jia B, "Effect of cysteamine on wool growth and expression of GH receptor, IGF-1 and type 1IGF receptors mRNA in the skin of sheep", J Nanjing Agric Univ, 28, pp.80~84 (2005)
- Du G, "Cysteamine improves growth performance and gastric ghrelin expression in preweaning piglets", Domest Anim Endocrinol, 42, pp.203~209 (2012)[DOI]
- Ueno H, "Ghrelin : a gastric peptide that regulates food intake and energy homeostasis", Regul Pept, 126, pp.11~19 (2005)[DOI]
- Liu H, "Effects of cysteamine hydrochloride on apparent nutrient digestibility, serum biochemical and antioxidant indices of lactating dairy cows", Acta Vet Zootech Sinic, 46, pp.416~423 (2015)[DOI]
- Shen ZM, "Effects of cysteamine compound(lactonin)on milk production and immune function of high yielding cows during weeks 20 through 42of lactation", Acta Vet Zootech Sin, 36, pp.667~673 (2005)
- Wang ZR, "Effects of enveloped cysteamine on buffalo rumen digestion and metabolism", J Xinjiang Agric Univ, 25, pp.42~47 (2002)
- McLeod KR, "Effects of exogenous somatostatin and cysteamine on net nutrient flux across the portal-drained viscera and liver of sheep during intraduodenal infusion of starch hydrolysate and casein", J Anim Sci, 75, pp.3026~3037 (1997)[DOI]
- Mackle TR, "Effects of insulin and postruminal supply of protein on use of amino acids by the mammary gland for milk protein synthesis", J Dairy Sci, 83, pp.93~105 (2000)[DOI]
- Heath T, "Dukes’ Physiology of domestic animals", Aust Vet J, 71, pp.187~ (1994)[DOI]
- Wu T, "Cysteamine-supplemented diet for cashmere goats : A potential strategy to inhibit rumen biohydrogenation and enhance plasma antioxidant capacity", Front Vet Sci, 9, pp.997091~ (2022)[DOI]
- Zhou X, "Microbiome and fermentation parameters in the rumen of dairy buffalo in response to ingestion associated with a diet supplemented with cysteamine and hemp seed oil", J Anim Physiol Anim Nutr, 106, pp.471~484 (2022)[DOI]
- Bergman EN, "Energy contributions of volatile fatty acids from the gastrointestinal tract in various species", Physiol Rev, 70, pp.567~590 (1990)[DOI]
- Quanjun W, "Effects of cysteamine on in vitro fermentation by rumen microbes from goats", J Huazhong Agric Univ, 21, pp.535~539 (2002)
- Barnett MC, "Triiodothyronine influences digesta kinetics and methane yield in sheep", Anim Prod Sci, 52, pp.572~577 (2012)[DOI]
- Liu Z, "Effects of cysteamine on the digestion and metabolism in sheep", Acta Vet Zootech Sin, 27, pp.212~219 (1996)
- Knapp JR, "Invited review : Enteric methane in dairy cattle production : quantifying the opportunities and impact of reducing emissions", J Dairy Sci, 97, pp.3231~3261 (2014)[DOI]
- Qiu HZ, "Effect of cysteamine on fatty acid composition in rat tissues and its mechanism", Master, pp.2009
- Liu L, "Effect of malic acid and octadecanic fatty acids on rumen fatty acids metabolization and methane production in vitro", Master, pp.2008
- Gao J, "The effects of the unsaturated degree of long-chain fatty acids on the rumen microbial protein content and the activities of transaminases and dehydrogenase in vitro", J Integr Agric, 15, pp.424~431 (2016)
- Fan Q, "Altitude influences microbial diversity and herbage fermentation in the rumen of yaks", BMC Microbiol, 20, pp.370~ (2020)[DOI]
- Cui X, "Selenium yeast dietary supplement affects rumen bacterial population dynamics and fermentation parameters of Tibetan sheep(Ovis aries)in alpine meadow", Front Microbiol, 12, pp.663945~ (2021)[DOI]
- Liu H, "Effect of dietary concentrate to forage ratio on growth performance, rumen fermentation and bacterial diversity of Tibetan sheep under barn feeding on the Qinghai-Tibetan plateau", PeerJ, 7, pp.e7462~ (2019)[DOI]
- Ramalho JB, "In vitro probiotic and antioxidant potential of Lactococcus lactis subsp. cremoris LL95 and its effect in mice behaviour", Nutrients, 11, pp.901~ (2019)[DOI]
- Xiong L, "Isolation and preliminary screening of a weissella confusa strain from giant panda(Ailuropoda melanoleuca)", Probiotics Antimicrob Proteins, 11, pp.535~544 (2019)[DOI]
- Fusco V, "The genus Weissella : taxonomy, ecology and biotechnological potential", Front Microbiol, 6, pp.155~ (2015)[DOI]
- Thomas F, "Environmental and gut bacteroidetes : the food connection", Front Microbiol, 2, pp.93~ (2011)[DOI]
- McMahon CD, "Neuroregulation of growth hormone secretion in domestic animals", Domest Anim Endocrinol, 20, pp.65~87 (2001)[DOI]
- Le Roith D, "The somatomedin hypothesis : 2001", Endocr Rev, 22, pp.53~74 (2001)[DOI]
- Wang Z, "Effects of cysteamine on goat rumen digestion and metabolism", China Herbivores, 117, pp.42~45 (2002)[DOI]
- Shokrollahi B, "Cysteamine administration in lambs grazing on mountain pastures : Effects on the body weight, antioxidant capacity, thyroid hormones and growth hormone secretion", Vet Med Sci, 8, pp.328~335 (2022)[DOI]
- Kirkwood RN, "The influence of growth hormone injections on the endocrine and metabolic status of gilts", Domest Anim Endocrinol, 6, pp.167~176 (1989)[DOI]
- Kleinberg DL, "Role of IGF-I in normal mammary development", Breast Cancer Res Treat, 47, pp.201~208 (1998)[DOI]
- Wood PL, "Cellular thiol pools are responsible for sequestration of cytotoxic reactive aldehydes : central role of free cysteine and cysteamine", Brain Res, 1158, pp.158~163 (2007)[DOI]
- Ruan W, "Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development", Endocrinology, 140, pp.5075~5081 (1999)[DOI]
- Le Roith D, "Insulin-like growth factor-I and insulin-like growth factor binding protein-3 inhibit involution of the mammary gland following lactation : studies in transgenic mice", Progr Growth Factor Res, 6, pp.433~436 (1995)[DOI]
- Kleinberg DL, "IGF-I, GH, and sex steroid effects in normal mammary gland development", J Mammary Gland Biol Neoplasia, 13, pp.353~360 (2008)[DOI]
- Weismann D, "Complement factor H binds malondialdehyde epitopes and protects from oxidative stress", Nature, 478, pp.76~81 (2011)[DOI]
- Jové M, "The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity", Antioxidants, 9, pp.1132~ (2020)[DOI]
- Zhang ZY, "Cysteamine alleviates early brain injury via reducing oxidative stress and apoptosis in a rat experimental subarachnoid hemorrhage model", Cell Mol Neurobiol, 35, pp.543~553 (2015)[DOI]
- Zhou P, "The interactions between cyste amine, cystine and cumulus cells increase the intracellular glutathione level and developmental capacity of goat cumulus denuded oocytes", Reproduction, 135, pp.605~611 (2008)[DOI]
- Jeitner TM, "Mechanisms for the cytotoxicity of cysteamine", Toxicol Sci, 63, pp.57~64 (2001)[DOI]
