Effects of 12 Weeks of Aerobic and Resistance Exercise on Adiponectin and VEGF in Middle-aged Women
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This study investigated the effects of 12 weeks of aerobic and resistance exercise on serum adiponectin and vascular endothelial growth factor (VEGF) in middle-aged women. Twelve participants without recent exercise experience were randomly assigned to an aerobic group (n = 6) or a resistance group (n = 6), and trained three times per week for 60 minutes. The aerobic group performed treadmill-based endurance exercise, while the resistance group completed machine-based strength training. After the intervention, VEGF levels significantly increased in the aerobic exercise group (p < .05), whereas no significant change was found in the resistance group. Serum adiponectin concentrations showed no significant changes within or between groups, indicating that exercise modality did not influence adiponectin levels over the 12-week period. These findings suggest that aerobic exercise may contribute to changes in angiogenesis-related biomarkers among middle-aged women. However, the small sample size and lack of a non-exercise control group limit the generalizability and causal interpretation of the findings. Future research should employ larger randomized controlled trials and incorporate direct measurements of vascular function to further clarify mechanisms associated with exercise-induced VEGF responses.
Abstract
This study investigated the effects of 12 weeks of aerobic and resistance exercise on serum adiponectin and vascular endothelial growth factor (VEGF) in middle-aged women. Twelve participants without recent exercise experience were randomly assigned to an aerobic group (n = 6) or a resistance group (n = 6), and trained three times per week for 60 minutes. The aerobic group performed treadmill-based endurance exercise, while the resistance group completed machine-based strength training. After the intervention, VEGF levels significantly increased in the aerobic exercise group (p < .05), whereas no significant change was found in the resistance group. Serum adiponectin concentrations showed no significant changes within or between groups, indicating that exercise modality did not influence adiponectin levels over the 12-week period. These findings suggest that aerobic exercise may contribute to changes in angiogenesis-related biomarkers among middle-aged women. However, the small sample size and lack of a non-exercise control group limit the generalizability and causal interpretation of the findings. Future research should employ larger randomized controlled trials and incorporate direct measurements of vascular function to further clarify mechanisms associated with exercise-induced VEGF responses.