Forensic Database Platform for Searching and Interpreting Mixed DNA Profiles
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DNA analysis of crime evidence often involves mixed DNA profiles from several individuals. The mixed DNA interpretation has been continually studied in forensic genetics, with many programs developed for DNA mixture analysis. Although most of these are freely available for performing required calculations, some of them do not provide a database wherein mixed DNA profiles can be searched and managed. The ‘DNA law’ was enacted in Korea, and the forensic DNA database is in operation except for mixed DNA profile. In this study, we developed a web-based system-the Forensic Mixed DNA Database (FMDD)-that allows searches of DNA profiles as well as statistical interpretation for matches. With the FMDD, a suspect’s DNA profile can be searched against a database of mixed DNA profiles and vice versa. Moreover, the FMDD provides different probabilities including the random match probability (RMP), combined probability of exclusion/inclusion (CPE/CPI), and likelihood ratio (LR). The LR of mixed DNA profiles from two individuals can be computed to obtain customized statistical results using various options available in the program. The multifunctionality of the FMDD make it an essential tool for the crime investigation that is expected to enhance the value of mixed DNA profile analyses.
Abstract
DNA analysis of crime evidence often involves mixed DNA profiles from several individuals. The mixed DNA interpretation has been continually studied in forensic genetics, with many programs developed for DNA mixture analysis. Although most of these are freely available for performing required calculations, some of them do not provide a database wherein mixed DNA profiles can be searched and managed. The ‘DNA law’ was enacted in Korea, and the forensic DNA database is in operation except for mixed DNA profile. In this study, we developed a web-based system-the Forensic Mixed DNA Database (FMDD)-that allows searches of DNA profiles as well as statistical interpretation for matches. With the FMDD, a suspect’s DNA profile can be searched against a database of mixed DNA profiles and vice versa. Moreover, the FMDD provides different probabilities including the random match probability (RMP), combined probability of exclusion/inclusion (CPE/CPI), and likelihood ratio (LR). The LR of mixed DNA profiles from two individuals can be computed to obtain customized statistical results using various options available in the program. The multifunctionality of the FMDD make it an essential tool for the crime investigation that is expected to enhance the value of mixed DNA profile analyses.
참고문헌 (22)
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