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산자나무(Hippophae rhamnoides L.) 추출물, 오일 및 이들을 함유한 나노에멀젼의 주름개선 효능 평가

Evaluation of Anti-wrinkle Efficacy in Seabuckthorn (Hippophae rhamnoides L.) Extracts, Oil and Nanoemlusion Containing them.

김나리|신중엽|최선정|이관모|경기열
한국화장품미용학회 (The Korean Society of Cosmetics and Cosmetology)|2016.12|한국화장품미용학회지 (Korean Society of Cosmetics and Cosmetology)|제6권 제2호|pp. 127-137

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참고문헌

키워드

Anti-wrinkleAnti-oxidationNanoemulsionSeabuckthornHippophae rhamnoids L.
주제분류미용

초록

This study was conducted to investigate antioxidant activity of fruit and leaf extracts of seabuckthorn (Hippophae rhamnoides L) by different solvents and then further evaluated the anti-wrinkle efficacy and cytotoxicity in seabuckthorn extracts, seabuckthorn oil, and the seabuckthorn seed oil nanoemulsion that emulsified the mixture of seabuckthorn leaf extract and seed oil. In total polyphenol and flavonoid contents, the contents of ethanol extracts were higher than that of water extracts. Especially, 70% ethanol extracts was the highest contents. Also, the total polyphenol and flavonoid contents of leaf extract were significantly higher than that of fruit extract. The flavonol and carotenoid contents were similar pattern as well. The DPPH radical scavenging activity of leaf extract was significantly higher than that of fruit extract and also increased in accordance with solvent concentrations. Therefore 70% ethanol extractions of fruit and leaf were optimum condition. In cytotoxicity and matrix metalloproteinase-1 (MMP-1) inhibitory activity, the seabuckthorn leaf ethanol extract and seed oil were no cytotoxicity and significantly MMP-1 inhibitory activity. Nanoemulsion that emulsified seabuckthorn leaf ethanol extract and seed oil has anti-wrinkle efficacy. In conclusion seabuctkorn leaf extract, seabuckthorn seed oil, and seabuckthorn nanoemulsion could be a potential functional source of cosmetics. key words

Abstract

This study was conducted to investigate antioxidant activity of fruit and leaf extracts of seabuckthorn (Hippophae rhamnoides L) by different solvents and then further evaluated the anti-wrinkle efficacy and cytotoxicity in seabuckthorn extracts, seabuckthorn oil, and the seabuckthorn seed oil nanoemulsion that emulsified the mixture of seabuckthorn leaf extract and seed oil. In total polyphenol and flavonoid contents, the contents of ethanol extracts were higher than that of water extracts. Especially, 70% ethanol extracts was the highest contents. Also, the total polyphenol and flavonoid contents of leaf extract were significantly higher than that of fruit extract. The flavonol and carotenoid contents were similar pattern as well. The DPPH radical scavenging activity of leaf extract was significantly higher than that of fruit extract and also increased in accordance with solvent concentrations. Therefore 70% ethanol extractions of fruit and leaf were optimum condition. In cytotoxicity and matrix metalloproteinase-1 (MMP-1) inhibitory activity, the seabuckthorn leaf ethanol extract and seed oil were no cytotoxicity and significantly MMP-1 inhibitory activity. Nanoemulsion that emulsified seabuckthorn leaf ethanol extract and seed oil has anti-wrinkle efficacy. In conclusion seabuctkorn leaf extract, seabuckthorn seed oil, and seabuckthorn nanoemulsion could be a potential functional source of cosmetics. key words

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