초음파 결합 마이크로니들 시스템을 통한 진정 및 재생 활성성분 경피전달
Transdermal Delivery of Calming and Rejuvenating Active Ingredients through Ultrasonic Coupling Microneedle System
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초록
미용치료 산업은 2000년대부터 전 세계적으로 성장해 왔다. 그러나 이러한 발전에도 불구하고 미용 시술로 인한 통증과 부작용에 대한 연구와 사후 관리는 뒤쳐져 왔다. 본 연구는 용해 마이크로니들 채널링 시스템과 초음파 처리의 장점을 결합한 새로운 장치를 제안하는데 그 목적이 있다. 레이저 피부미용 시술(Skin LASER) 및 마이크로니들링 테라피 시스템(MTS)과 같은 기존 치료법의 단점을 극복하기 위해 용해 마이크로니들링 시스템과 초음파 치료법이 개발되었다. KS-DMCS로 알려진 용해성 마이크로니들 채널링 시스템에는 용해성 마이크로니들 채널링 시스템과 초음파 처리의 단점을 해결하기 위해 수크랄페이트 0.5%와 비타민 K 3% 용액을 적용하여 마이크로니들에 의한 상처 치유를 용이하게 한다. 또한, 액체 산소 화장품이 함유된 외부 세럼(Ceutisome Serum)을 사용하여 피부 세포를 활성화한다. 실험 결과 초음파 처리와 용해 마이크로니들 채널링 시스템의 조합이 상당한 개선을 나타냄을 확인하였으며, 타당성 테스트를 통해 마이크로 니들과 Sucralfate 0.5% 및 Vitamin K 3% 혼합 용액과 서로 반응치 않는 안정성을 확인하였다. 또한 액체산소가 함유된 세럼이 Sucralfate 0.5% 및 Vitamin K 3% 혼합 용액과 간섭 반응성 없이 목표 깊이까지 확산되는 것을 확인할 수 있었다. 따라서 초음파 처리와 용해 마이크로니들 채널링 시스템의 조합은 용해 마이크로니들 채널링 시스템을 단독으로 사용하거나 초음파 처리를 단독으로 사용하는 경우보다 더 나은 경피전달 효과를 보이며, 각 활성 성분을 원하는 깊이까지 성공적으로 전달할 수 있다. 본 연구에서는 이러한 조합을 사용자에게 통증이나 부작용을 주지 않으면서 스킨케어의 효능을 높이고 유효성분의 전달을 용이하게 하는 시스템을 위한 혁신적인 전략으로 제안하고자 한다.
Abstract
The beauty treatment industry has been growing worldwide since the 2000s. However, despite this progress, research and post-treatment care for the pain and side effects caused by beauty care treatments have been lagging behind. This study proposes a new device that combines the advantages of the Dissolving Microneedle Channeling System and ultrasonic treatment. Dissolving Microneedle Channeling System and ultrasonic treatment have been developed to overcome the drawbacks of conventional treatments such as laser skin resurfacing and Microneedling Therapy Systems (MTS). To address the disadvantages of Dissolving Microneedle Channeling System and ultrasonic treatment, a Sucralfate 0.5% and Vitamin K 3% solution is applied to the Dissolving Microneedle Channeling System, which is known as KS-DMCS, to facilitate wound healing caused by the microneedles. Additionally, an external serum (Ceutisome Serum) containing liquid oxygen cosmetics is used to activate skin cells. Experimental results confirm that the combination of ultrasonic treatment and Dissolving Microneedle Channeling System demonstrates significant improvement. The feasibility test confirms the stability of the Sucralfate 0.5% and Vitamin K 3% solution with the needle array. It is also confirmed that the serum, which contains liquid oxygen cosmetics, diffuses to the target depth without interference from the Sucralfate 0.5% and Vitamin K 3% solution. Therefore, the combination of ultrasonic treatment and Dissolving Microneedle Channeling System exhibits a better delivery effect compared to using Dissolving Microneedle Channeling System or ultrasonic treatment alone, successfully delivering each active ingredient to the desired depth. This study proposes this combination as an innovative strategy for a system that enhances the efficacy of skincare and facilitates the delivery of active ingredients without causing pain or side effects to the user.
참고문헌 (39)
- 박윤미, "코로나19(COVID-19) 발생 이전•이후의 여성 화장 관심도 및 화장품 사용실태 변화 분석", 아시안뷰티화장품학술지, 19(1), pp.129~138 (2021), 한국피부과학연구원[DOI]
- 백혜연, "COVID-19 이후 뷰티산업 전망에 관한 연구", 한국화장품미용학회지, 11(3), pp.335~341 (2021), 한국화장품미용학회
- 신진영, "메디컬 스킨케어의 인식 및 만족도에 관한 연구", 한국미용학회지, 15(3), pp.786~802 (2009), 한국미용학회
- 우재현, "피부 미용치료후 산소미스트 후처치가 피부에 미치는 영향에 관한 연구", 한국화장품미용학회지, 3(2), pp.133~143 (2013), 한국화장품미용학회
- 표영희, "K-Beauty 미용산업 활성화 방안에 관한 연구", 융합정보논문지, 11(12), pp.229~235 (2021), 중소기업융합학회[DOI]
- A. Z. Alkilani, "Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Proper ties of the stratum corneum", Pharmaceutics, 7(4), pp.438~470 (2015)
- C. Englert, "Pharmapolymers in the 21st century: Synthetic polymers in drug delivery applications", Prog. Polym, Sci, 87, pp.107~164 (2018)
- C. Chubb, "Efficacy of perfluorodecalin as an oxygen carrier for mouse and rat testes perfused in vitro", Proc. Soc. Exp. Biol. Med, 184(4), pp.489~494 (1987)
- C. Jeon, "Micro-pillar tunnel stamp for enhanced transderma l delivery of topical drug formulations", Acta Biomater, 160, pp.112~122 (2023)
- E. Tim, "A novel method for producing solid polymer microneed les using laser ablated moulds in an injection moulding process", Manuf. Lett, 24, pp.29~32 (2020)
- F. Spada, "Skin hydration is significantly increased by a cream formulated to mimi c the skin's own natural moisturizing systems", Clin Cos met Investig Dermatol, 11, pp.491~497 (2018)
- G. Kang, "Adenosine-loaded dissolvi ng microneedle patches to improve skin wrinkles, derm al density, elasticity and hydration", Int. J. Cosmet. Sci, 40(2), pp.199~206 (2018)
- G. Kang, "Combinatorial ap plication of dissolving microneedle patch and cream for improvement of skin wrinkles, dermal density, elasticity, and hydration", J Cosmet Dermatol, 18(4), pp.1083~1091 (2019)
- H. Yang, "Centrifugal Lithography: Self-Shaping of Polymer Microstructures Enc apsulating Biopharmaceutics by Centrifuging Polymer Drops", Adv. Healthc. Mater, 6(19), pp.10~ (2017)
- H. Mittelman, "Carbon dioxide laser blepharoplasty--advantages and disadvantages", Ann. Plast. Surg, 24(1), pp.1~6 (1990)
- J. W. Lee, "Dissolving microneedle patch for transdermal delivery of human growth hormone", Small, 7(4), pp.531~539 (2011)
- J. Ohn, "Dissolving Candlelit Microneedle for Chronic Inflammatory Skin Diseases", Adv. Sci, 8(14), pp.2004873~ (2021)
- J. Sim, "Enhanced Micro-Channeling System via Dissolving Microneedle to Improve Transdermal Serum Delivery for Various Clinical Skincare Treatments", Pharmaceutics, 14(12), pp.2804~ (2022)
- J. D. Bos, "The 500 Dalton rule for the skin penetration of chemical compounds and drugs", Exp. Dermatol, 9(3), pp.165~169 (2000)
- K. M. AlGhamdi, "Depigmentation therapi es for normal skin in vitiligo universalis", JEADV, 25(7), pp.749~757 (2011)
- K. Ita, "Transdermal Delivery of Drugs with Microneedles -Potential and Challenges", Pharmaceutics, 7(3), pp.90~105 (2015)
- K. Moser, "Passive skin penetration enhancement and its quantification in vitro", European journal of pharmaceutics and biopharmaceutics: Eur J Pharm Biopharm, 52(2), pp.103~112 (2001)
- L. He, "Appropriate ultrasoni c treatment improves the production of antioxidant pept ides by modifying gelatin extracted from yak skin", Int J Food Sci Technol, 57, pp.5897~5908 (2022)
- L. Dsouza, "Derma rollers in therapy: the transition from cosmetics to transdermal drug delivery", Biomed microdevices, 22(4), pp.77~ (2020)
- M. C. Kearney, "Design and Development of Liquid Drug Reservoirs for Microneedle Delivery of Poorly Soluble Drug Molecules", Pharmaceutics, 11(11), pp.605~ (2019)
- M. El-Domyati, "Microneedling Therapy for Atrophic Acne Scars: An Objective Evaluation", JCAD, 8(7), pp.36~42 (2015)
- M. L. Abella, "Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS technique", In t. J.Cosmet. Sci, 28(6), pp.447~451 (2006)
- N. Pazyar, "Wound healing effects of topical Vitamin K: A randomized controlled trial", Indian J. Pharmacol, 51(2), pp.88~92 (2019)
- P. J. Gupta, "Topical sucralfate decreases pain after hemorrhoidectomy and improves healing: a randomized, blinded, controlled study", Dis. Colon Rectum, 51(2), pp.231~234 (2008)
- M. R. Prausnitz, "Transdermal drug delivery", Nat. Biotechnol, 26(11), pp.1261~1268 (2008)
- R. Amarnani, "Microneedles in diagnostic, treatment and theranostics: An advancement in mini mally-invasive delivery system", Biomed Microdevices, 24(1), pp.4~ (2021)
- S. Ciurlea, "A comparative study regarding melanoma activity of Betulinic acid on topical ointment vs systemic nanoemulsion delivery systems", J. Agroaliment. Process Technol, 16, pp.420~426 (2010)
- S. Kim, "Enhanced Transdermal Delivery by Combined Application of Dissolving Microneedle Patch on Serum-Treated Skin", Mol. Pharm, 14(6), pp.2024~2031 (2017)
- T. Ruzicka, "A short-term tria l of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group", NEJM, 337(12), pp.816~821 (1997)
- T. Waghule, "Microneedles: A smart approach and increasing potential for transdermal drug delivery system", Biomed. Pharmacothe, 109, pp.1249~1258 (2019)
- T. Marjukka Suhonen, "hemical enhancement of percutaneous absorption in relati on to stratum corneum structural alteration", J Control Release, 59(2), pp.149~161 (1999)
- Woo Yeup Jeong, "Recent advances in transdermal drug delivery systems: a review", 생체재료학회지, 25(3), pp.243~257 (2021), 한국생체재료학회[DOI]
- X. Huo, "Effect of different treatments on recurrent aphthous stomatitis: laser versus medication", Lasers Med Sci, 36(5), pp.1095~1100 (2021)