Effectiveness of cryotherapy in preventing oral mucositis in pediatric cancer patients in Jordan: a randomized controlled trial
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: The study aimed to evaluate the effectiveness of cryotherapy in preventing oralmucositis in pediatric patients receiving chemotherapy. Methods: An evidence-basedpractice project utilized a randomized control trial design with two groups (experimentaland control groups). Fifty-nine pediatric patients with cancer in Jordan, aged 8–18 years,were randomly assigned to the experimental group (n=29) or the control group (n=30). The intervention was conducted from June 2022 to December 2022. The severity of oralmucositis among pediatric cancer patients was assessed using the World Health Organizationoral mucositis grade. Results: There were no significant differences in sex or diseasetype among the groups. On days 7, 14, and 21, we observed notable between-groupdifferences in treatment responses and the intensity of oral mucositis, highlighting theefficacy of cryotherapy in diminishing the severity of oral mucositis. Conclusion: Thisstudy supports the use of cryotherapy as a preventive measure for oral mucositis amongpediatric oncology patients in Jordan. The findings suggest that cryotherapy effectivelyreduces the severity of oral mucositis. Further research is necessary to investigate thebroader impacts of cryotherapy.
Abstract
Purpose: The study aimed to evaluate the effectiveness of cryotherapy in preventing oralmucositis in pediatric patients receiving chemotherapy. Methods: An evidence-basedpractice project utilized a randomized control trial design with two groups (experimentaland control groups). Fifty-nine pediatric patients with cancer in Jordan, aged 8–18 years,were randomly assigned to the experimental group (n=29) or the control group (n=30). The intervention was conducted from June 2022 to December 2022. The severity of oralmucositis among pediatric cancer patients was assessed using the World Health Organizationoral mucositis grade. Results: There were no significant differences in sex or diseasetype among the groups. On days 7, 14, and 21, we observed notable between-groupdifferences in treatment responses and the intensity of oral mucositis, highlighting theefficacy of cryotherapy in diminishing the severity of oral mucositis. Conclusion: Thisstudy supports the use of cryotherapy as a preventive measure for oral mucositis amongpediatric oncology patients in Jordan. The findings suggest that cryotherapy effectivelyreduces the severity of oral mucositis. Further research is necessary to investigate thebroader impacts of cryotherapy.
참고문헌 (22)
- Colella G, "Interventions for the prevention of oral mucositis in patients receiving cancer treatment : evidence from randomised controlled trials", Current Oncology, 30(1), pp.967~980 (2023)[DOI]
- Bell A, "StatPearls" (2023)
- Ribeiro ILA, "Oral mucositis in pediatric oncology patients : a nested case-control to a prospective cohort", Brazilian Dental Journal, 31(1), pp.78~88 (2020)[DOI]
- Allan R, "Cold for centuries : a brief history of cryotherapies to improve health, injury and post-exercise recovery", European Journal of Applied Physiology, 122, pp.1153~1162 (2022)[DOI]
- Correa MEP, "Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines", Supportive Care in Cancer, 28(5), pp.2449~2456 (2020)[DOI]
- Riley P, "Oral cryotherapy for preventing oral mucositis in patients receiving cancer treatment", JAMA Oncology, 2(10), pp.1365~1366 (2016)[DOI]
- Elad S, "MASCC", ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy, 2020, pp.126(19), 4423~4431
- Lee CC, "Effectiveness of cryotherapy on cancer therapy-induced oral mucositis : an umbrella review", Cancer Nursing, 46(5), pp.E288~E296 (2023)[DOI]
- Al-Rudayni AHM, "Efficacy of photobiomodulation in the treatment of cancer chemotherapy-induced oral mucositis : a meta-analysis with trial sequential analysis", International Journal of Environmental Research and Public Health, 18(14), pp.7418~ (2021)[DOI]
- Katrancı N, "Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy-a randomized controlled trial", European Journal of Oncology Nursing, 16(4), pp.339~344 (2012)[DOI]
- Kawaguchi K, "Effects of cryotherapy on high-dose melphalan-induced oral mucositis in pediatric patients undergoing autologous stem cell transplantation", Pediatric Blood & Cancer, 67(9), pp.e28495~ (2020)[DOI]
- Griffiths C, "Cold therapy to prevent paclitaxel-induced peripheral neuropathy", Supportive Care in Cancer, 26(10), pp.3461~3469 (2018)[DOI]
- Lilleby K, "A prospective, randomized study of cryotherapy during administration of high-dose melphalan to decrease the severity and duration of oral mucositis in patients with multiple myeloma undergoing autologous peripheral blood stem cell transplantation", Bone Marrow Transplantation, 37(11), pp.1031~1035 (2006)[DOI]
- Al-Rudayni AHM, "Efficacy of oral cryotherapy in the prevention of oral mucositis associated with cancer chemotherapy : systematic review with meta-analysis and trial sequential analysis", Current Oncology, 28(4), pp.2852~2867 (2021)[DOI]
- Ahuja AS, "Should RCT’s be used as the gold standard for evidence based medicine?", Integrative Medicine Research, 8(1), pp.31~32 (2019)[DOI]
- von Elm E, "The Strengthening the Reporting of Observational Studies in Epidemiology(STROBE)statement : guidelines for reporting observational studies", Journal of Clinical Epidemiology, 61(4), pp.344~349 (2008)[DOI]
- Cohen J, "A power primer", Psychological Bulletin, 112(1), pp.155~159 (1992)[DOI]
- "World Health Organization Oral Mucositis Scale (WHO Oral Mucositis Scale)" (2006)[URL]
- Patel P, "Clinical practice guideline for the prevention of oral and oropharyngeal mucositis in pediatric cancer and hematopoietic stem cell transplant patients : 2021 update", European Journal of Cancer, 154, pp.92~101 (2021)[DOI]
- Alsulami FJ, "Oral cryotherapy for management of chemotherapy-induced oral mucositis in haematopoietic cell transplantation : a systematic review", BMC Cancer, 22(1), pp.442~ (2022)[DOI]
- Kamsvåg T, "Prevention of oral mucositis with cryotherapy in children undergoing hematopoietic stem cell transplantations-a feasibility study and randomized controlled trial", Supportive Care in Cancer, 28(10), pp.4869~4879 (2020)[DOI]
- Garcia C, "Use of cryotherapy for managing chronic pain : an evidence-based narrative", Pain and Therapy, 10(1), pp.81~100 (2021)[DOI]