본문 바로가기
KERD
논문KCI 등재

Nano and micro structures for label-free detection of biomolecules

손영수|권태윤|엄길호
한국센서학회|2010.11|센서학회지 (Journal of Sensor Science and Technology)|제19권 제6호|pp. 403-420

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

resonatorbiosensorsnano/micro structurelabel-freenanowire FET
주제분류공학일반

초록

Nano and micro structure-based biosensors are promising tool for label-free detection of biomolecular interactions with great accuracy. This review gives a brief survey on nano and micro platforms to sense a variety of analytes such as DNA, proteins and viruses. Among incredible nano and micro structure for bio-analytical applications, the scope of this paper will be limited to micro and nano resonators and nanowire field-effect transistors. Nanomechanical motion of the resonators transducers biological information to readable signals. They are commonly combined with an optical, capacitive or piezo-resistive detection systems. Binding of target molecule to the modified surface of nanowire modulates the current of the nanowire through electrical field-effect. Both detection methods have advantages of label-free, real-time and high sensitive detection. These structures can be extended to fabricate array-type sensors for multiplexed detection and highthroughput analysis. The biosensors based on these structures will be applied to lab-on-a-chip platforms and point-ofcare diagnostics. Basic concepts including detection mechanisms and trends in their fields will be covered in this review.

Abstract

Nano and micro structure-based biosensors are promising tool for label-free detection of biomolecular interactions with great accuracy. This review gives a brief survey on nano and micro platforms to sense a variety of analytes such as DNA, proteins and viruses. Among incredible nano and micro structure for bio-analytical applications, the scope of this paper will be limited to micro and nano resonators and nanowire field-effect transistors. Nanomechanical motion of the resonators transducers biological information to readable signals. They are commonly combined with an optical, capacitive or piezo-resistive detection systems. Binding of target molecule to the modified surface of nanowire modulates the current of the nanowire through electrical field-effect. Both detection methods have advantages of label-free, real-time and high sensitive detection. These structures can be extended to fabricate array-type sensors for multiplexed detection and highthroughput analysis. The biosensors based on these structures will be applied to lab-on-a-chip platforms and point-ofcare diagnostics. Basic concepts including detection mechanisms and trends in their fields will be covered in this review.

참고문헌 (77)

  1. M. A. Cooper, "Label-free biosensors" (2009)
  2. L. G. Carrascosa, "Nanomechanical biosensors:a new sensing tool", Trac-Trends Anal. Chem, 25, pp.196~206 (2005)
  3. S. Choi, "Surface plasmon resonance protein sensor using vroman effect", Bio­sens. Bioelectron, 24, pp.893~899 (2008)
  4. Y. T. Yang, "Zeptogram-scale nanomechan­ical mass sensing", Nano Lett, 6, pp.583~586 (2006)
  5. M. Li, "Ultra-sen­sitive NEMS-based cantilevers for sensing,scanned probe and very high-frequency applications", Nat. Nanotechnol, 2, pp.114~120 (2007)
  6. K. Jensen, "An atomic-reso­lution nanomechanical mass sensor", Nat. Nano­technol, 3, pp.533~537 (2008)
  7. J. Lagowski, "Sur­face stress and the normal mode of vibration of thin crystals:GaAs", Appl. Phys. Lett, 26, pp.493~495 (1975)
  8. P. Lu, "Surface stress effects on the resonance properties of canti­lever sensors", Phys. Rev. B, 72, pp.85~405 (2005)
  9. K. Eom, "Experimental and Computational Characterization of Biological Liq­uid Crystals:A Review of Single-Molecule Bioas­says", Int. J. Mol. Sci, 10, pp.4009~4032 (2009)
  10. D. J. Muller, "Atomic force microscopy as a multifunctional molecular toolbox in nanobiotechnology", Nat. Nanotechnol, 3, pp.261~269 (2008)
  11. K. M. Goeders, "Microcantilevers:Sensing Chemical Interactions via Mechanical Motion", Chem. Rev, 108, pp.522~542 (2008)
  12. G.G.Stoney, "The tension of metallic films depos­ited by electrolysis", Proc. R. Soc. Lond. A, 82, pp.172~175 (1909)
  13. R. Berger, "Surface stress in the self-assembly of alkanethiols on gold", Science, 276, pp.2021~2024 (1997)
  14. T. Kwon, "Nanomechanical in situ monitoring of pro­teolysis of peptide by cathepsin B", PLoS ONE, 4, pp.e6248~ (2009)
  15. K. Castelino, "Char­acterization of grafting density and binding effi­ciency of DNA and proteins on gold surfaces", Langmuir, 21, pp.1956~1961 (2005)
  16. T. Y. Kwon, "In situ real-time monitoring of biomolecular interactions based on resonating microcantilevers immersed in a viscous fluid", Appl. Phys. Lett, 90, pp.223903~ (2007)
  17. P. S. Waggoner, "Micro-and nanomechanical sensors for environmental,chemi­cal,and biological detection", Lab Chip, 7, pp.1238~1255 (2007)
  18. G. H. Wu, "Bioassay of prostate-specific antigen(PSA)using microcantilevers", Nat. Biotechnol, 19, pp.856~860 (2001)
  19. J. Zhang, "Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA", Nat. Nanotechnol, 1, pp.214~220 (2006)
  20. J. Fritz, "Translating biomolecular recog­nition into nanomechanics", Science, 288, pp.316~318 (2000)
  21. R. McKendry, "Multiple label-free biodetection and quantitative DNA-bind­ing assays on a nanomechanical cantilever array", Proc. Natl. Acad. Sci. USA, 99, pp.9783~9788 (2002)
  22. G. H. Wu, "Origin of nanomechanical cantilever motion generated from biomolecular interactions", Proc. Natl. Acad. Sci. USA, 98, pp.1560~1564 (2001)
  23. J. W. Ndieyira, "Nanomechanical detection of antibiotic-mucopeptide binding in a model for superbug drug resistance", Nat. Nanotechnol, 3, pp.691~696 (2008)
  24. T. Braun, "Micromechanical mass sensors for biomolecular detection in a physiological environment", Phys. Rev. E, 72, pp.031907~ (2005)
  25. D. W. Chun, "Detection of the Au thin-layer in the Hz per pico­gram regime based on the microcantilevers", Sens. Actuat. A, 135, pp.857~862 (2007)
  26. W.Haiss, "Surface stress of clean and adsorbate-covered solids", Rep. Prog. Phys, 64, pp.591~ (2001)
  27. H.Ibach, "The role of surface stress in reconstruc­tion,epitaxial growth,and stabilization of mesos­copic structures", Surf. Sci. Rep, 29, pp.193~263 (1997)
  28. L. B. Freund, "Thin Film Materials" (2003), Cambridge University Press
  29. B. Ilic, "Enumeration of DNA molecules bound to a nanomechanical oscillator", Nano Lett, 5, pp.925~929 (2005)
  30. T. P. Burg, "Weighing of biomolecules,single cells and sin­gle nanoparticles in fluid", Nature, 446, pp.1066~1069 (2007)
  31. A. K. Bryan, "Measurement of mass,density,and vol­ume during the cell cycle of yeast", Proc. Natl. Acad. Sci. USA, 107, pp.999~1004 (2010)
  32. K. Y. Gfeller, "Micro­mechanical oscillators as rapid biosensor for the detection of active growth of escherichia coli", Bio­sens. Bioelectron, 21, pp.528~533 (2005)
  33. N. Nugaeva, "Microme­chanical cantilever array sensors for selective fungal immobilization and fast growth detection", Biosens. Bioelectron, 21, pp.849~856 (2005)
  34. B. Ilic, "Mechanical resonant immunospecific biological detector", Appl. Phys. Lett, 77, pp.450~452 (2000)
  35. A. P. Davila, "Microresonator mass sen­sors for detection of bacillus anthracis sterne spores in air and water", Biosens. Bioelectron, 22, pp.3028~3035 (2007)
  36. S. S. Verbridge, "Optically driven resonance of nanos­cale flexural oscillators in liquid", Nano Lett, 6, pp.2109~2114 (2006)
  37. T. P. Burg, "Suspended micro-channel resonators for biomolecular detection", Appl. Phys. Lett, 83, pp.2698~2700 (2003)
  38. M. Su, "Microcantilever res­onance-based DNA detection with nanoparticle probes", Appl. Phys. Lett, 82, pp.3562~3564 (2003)
  39. T. Kwon, "Micromechanical observation of the kinetics of biomolecular interactions", Appl. Phys. Lett, 93, pp.173901~ (2008)
  40. J. H. Lee, "Effect of mass and stress on resonant frequency shift of func­tionalized Pb(Zr0.52Ti0.48)O-3 thin film microcan­tilever for the detection of C-reactive protein", Appl. Phys. Lett, 84, pp.3187~3189 (2004)
  41. M. Varshney, "Prion protein detection using nanomechanical resonator arrays and secondary mass labeling", Anal. Chem, 80, pp.2141~2148 (2008)
  42. T.Kodadek, "Biochemistry:molecular cloaking devices", Nature, 453, pp.861~862 (2008)
  43. J. S. Sebolt-Leopold, "Mecha­nisms of drug inhibition of signalling molecules", Nature, 441, pp.457~462 (2006)
  44. I. Kozinsky, "Tuning nonlinearity,dynamic range,and frequency of nanomechanical resonators", Appl. Phys. Lett, 88, pp.253101~ (2006)
  45. H. W. C. Postma, "Dynamic range of nanotube-and nanowire-based electromechanical systems", Appl. Phys. Lett, 86, pp.223105~ (2005)
  46. X. M. H. Huang, "VHF,UHF and microwave frequency nanomechanical resonators", New J. Phys, 7, pp.247~ (2005)
  47. M. D. Dai, "Nanomechan­ical mass detection using nonlinear oscillations", Appl. Phys. Lett, 95, pp.203104~ (2009)
  48. L. Meirovitch, "Analytical methods in vibrations" (1967), Macmillan
  49. J. T. Oden, "Finite Ele­ments: An Introduction(Vol. 1)" (1981), Prentice Hall
  50. J. T. Oden, "An Introduction to the Mathematical Theory of Finite Elements" (1976), John Wiley & Sons
  51. J. K. Hale, "Oscillations in Nonlinear Systems" (1963), McGraw-Hill
  52. C. Hayashi, "Nonlinear Oscillations in Physical Sys­tems" (1964), McGraw-Hill
  53. S. Cherian, "Determination of adsorption-induced variation in the spring constant of a microcantilever", Appl. Phys. Lett, 80, pp.2219~2221 (2002)
  54. A. W. McFarland, "Influence of surface stress on the resonance behavior of microcantile­vers", Appl. Phys. Lett, 87, pp.053505~ (2005)
  55. K. S. Hwang, "Dominant surface stress driven by biomolecular interactions in the dynamical response of nanome­chanical microcantilevers", Appl. Phys. Lett, 89, pp.173905~ (2006)
  56. J. Dorignac, "Dynamical response of nanomechanical oscillators in immiscible viscous fluid for in vitro biomolecular recognition", Phys. Rev. Lett, 96, pp.186105~ (2006)
  57. M. E. Gurtin, "Effect of surface stress on the natural frequency of thin crystals", Appl. Phys. Lett, 29, pp.529~530 (1976)
  58. M. J. Lachut, "Effect of Surface Stress on the Stiffness of Cantilever Plates", Phys. Rev. Lett, 99, pp.206102~ (2007)
  59. M. J. Lachut, "Effect of surface stress on the stiffness of cantilever plates:Influence of cantilever geometry", Appl. Phys. Lett, 95, pp.193~505 (2009)
  60. M. F. Hagan, "Nanomechanical Forces Generated by Surface Grafted DNA", J. Phys. Chem. B, 106, pp.10163~10173 (2002)
  61. K. Eom, "Dynamical response of nanomechanical resonators to biomolecular interactions", Phys. Rev. B, 76, pp.113408~ (2007)
  62. X. Yi, "Surface stress induced by interactions of adsorbates and its effect on deforma­tion and frequency of microcantilever sensors", J. Mech. Phys. Solids, 57, pp.1254~1266 (2009)
  63. G.-Y. Huang, "Model for the adsorption-induced change in resonance frequency of a cantilever", Appl. Phys. Lett, 89, pp.043506~ (2006)
  64. E. Stern, "Importance of the debye screening length on nanowire field effect transistor sensors", Nano Lett, 7, pp.3405~3409 (2007)
  65. Y. Cui, "Nanow­ire nanosensors for highly sensitive and selective detection of biological and chemical species", Sci­ence, 293, pp.1289~1292 (2001)
  66. M. Curreli, "Real­time,label-free detection of biological entities using nanowire-based fets", IEEE Trans. Nanotechnol, 7, pp.651~667 (2008)
  67. Z. Gao, "Silicon nanowire arrays for label-free detection of DNA", Anal. Chem, 79, pp.3291~3297 (2007)
  68. K.-Y. Park, "Developemt of FET-type albumin sensor for diagnosing nephritis", Biosens. Bioelectron, 23, pp.1904~1907 (2008)
  69. F. Patolsky, "Nanowire-based nanoelectronic devices in the life sciences", MRS Bull, 32, pp.142~149 (2007)
  70. M. J. Schoning, "Recent advances in biologically sensitive field-effect transistors(BioFETs)", Analyst, 127, pp.1137~1151 (2002)
  71. A. Kim, "Ultrasensitive,labe-free,and real-time immunode­tection using silicon field-effect transistors", Appl. Phys. Lett, 91, pp.103901~ (2007)
  72. W. U. Wang, "Label-free detection of small-molecule­protein interactions by using nanowire nanosen­sors", Proc. Natl. Acad. Sci, 102, pp.3208~3212 (2005)
  73. F. Patolsky, "Fabrica­tion of silicon nanowire devices for ultrasensitive,label-free,real-time detection of biological and chemical species", Nat. Protoc, 1, pp.1711~1724 (2006)
  74. E. Stern, "Label­free immunodetection with CMOS-compatible semiconducting nanowires", Nature Letters, 445, pp.519~522 (2007)
  75. Y. Chen, "Silicon-based nanoelectronic field-effect pH sensor with local gate control", Appl. Phys. Lett, 89, pp.223~512 (2006)
  76. Y.-S. Sohn, "Fabrication of silicon nanowire field-effect transistor biosensor by CMOS compatible top-down approach with des­cum process", Sensor Lett, 7, pp.1039~1043 (2009)
  77. C. W. Park, "Control of channel doping concentration for enhancing the sensitivity of ‘top-down’ fabricated Si nanochannel FET biosensors", Nanotechnology, 20, pp.475~501 (2009)

관련 논문AI추천

Nanowell Array based Sensor and Its Packaging이주경, 이혜연, 정명영, Tsuda Akira한국마이크로전자및패키징학회 · 마이크로전자 및 패키징학회지2014 · 제21권 제3호바이오센서김상경, 김태송, 황교선한국센서학회 · 센서학회지2009 · 제18권 제4호Short Review on Quartz Crystal Microbalance Sensors for Physical, Chemical, and Biological Applications김회준, 장일류한국센서학회 · 센서학회지2022 · 제31권 제6호Aptamer-based optical switch for biosensors이주운, 조은정, 조정환한국분석과학회 · 분석과학2014 · 제27권 제3호Electrochemical Biosensors for Biomedical and Clinical Applications: A Review박덕수, Md. Aminur Rahman, Yoon-Bo Shim대한의용생체공학회 · 의공학회지2005 · 제26권 제5호Detection of Protein Molecules by Electrical Current Response Using Two-Electrode Method류홍근, 신장규, 우성호, 이희호, 한윤수한국센서학회 · 센서학회지2011 · 제20권 제2호

이 간행물의 다른 논문 (12건)

Alizarin Red S modified electrochemical sensors for the detection of aluminum ion장승철pp. 421-427측면 연마 광섬유를 이용한 휘발성 유기 화합물 가스센서Yuan Heng, 김학린, 강신원, 임준우, 염세혁pp. 428-434체온측정용 온도 센서 및 모니터링 텔레메트리 시스템 구현김명남, 성기웅, 조진호, 이정현pp. 435-442CsI:Na 결정 육성과 섬광 특성김홍주, 천종규, 김성환pp. 443-448고효율 전자기형 정원창 구동 트랜스듀서의 설계김명남, 조진호, 김동욱, 이장우pp. 449-455
원문 보기