Characteristics of a Bimetal-Layer Chip of a Surface Plasmon Resonance Sensorin the Intensity Interrogation for Tumor Marker Detection
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The characteristics of a bimetallic surface plasmon resonance (SPR) chip were investigated to detect a tumor biomarker, car-cinoembryonic antigen (CEA). The linewidth and the tangential slope of the reflectance curve of the bimetallic SPR chip was comparedwith those of the reflectance curve of a conventional gold (Au) SPR chip. The changes in reflectance in response to the variation inCEA in the critical concentration range were analyzed at an angle where the tangential slope of the reflectance curve was maximum.From linear regression analysis, the sensitivity of the bimetallic SPR chip with respect to the CEA in critical concentration was obtained.
Abstract
The characteristics of a bimetallic surface plasmon resonance (SPR) chip were investigated to detect a tumor biomarker, car-cinoembryonic antigen (CEA). The linewidth and the tangential slope of the reflectance curve of the bimetallic SPR chip was comparedwith those of the reflectance curve of a conventional gold (Au) SPR chip. The changes in reflectance in response to the variation inCEA in the critical concentration range were analyzed at an angle where the tangential slope of the reflectance curve was maximum.From linear regression analysis, the sensitivity of the bimetallic SPR chip with respect to the CEA in critical concentration was obtained.
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